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Authordc.contributor.authorFernández, Mario I. 
Authordc.contributor.authorValdebenito, Patricio 
Authordc.contributor.authorDelgado, Iris 
Authordc.contributor.authorSegebre, Jorge 
Authordc.contributor.authorChaparro, Eduardo 
Authordc.contributor.authorFuentealba, David 
Authordc.contributor.authorCastillo, Martín 
Authordc.contributor.authorVial, Cecilia 
Authordc.contributor.authorBarroso, Juan P. 
Authordc.contributor.authorZiegler, Annemarie 
Authordc.contributor.authorBustamante, Alberto 
Cita de ítemdc.identifier.citationUrologic Oncology: Seminars and Original Investigations 38 (2020) 40.e1−40.e7es_ES
Abstractdc.description.abstractBackground: Beyond exposure to arsenic in drinking-water, there is few information about demographic and clinicopathological features of patients with bladder cancer living in arsenic-exposed regions. The aim of the study was to assess the impact of arsenic exposure on clinicopathological characteristics in patients with bladder cancer from a contaminated region compared to those of 2 reference areas. Methods: Data of 285 patients with bladder cancer (83 with arsenic exposure from Antofagasta and 202 controls from 2 different sites in Santiago) were obtained through personal interviews and from review of medical records. Demographic, clinicopathological parameters, and information on relevant environmental risk factors were compared with parametric and nonparametric tests as needed. Multivariable analysis was performed to identify independent predictors for high grade and muscle-invasive disease (T2-4). Results: We found no significant differences between groups regarding age at presentation (66.4 vs. 66.5 and 67.2 years; P = 0.69, for exposed vs. the 2 nonexposed groups, respectively) and female gender (28.9% vs. 29.8% and 26.2%; P = 0.84). Proportion of current smokers was significantly lower in the exposed population (10.7% vs. 38.6% and 26.9%; P < 0.001). There was a significantly higher proportion of locally advanced (10.8 vs. 1.8 and 0.7% T3/4; P = 0.002) and high-grade tumors (79.5% vs. 63.2% and 64.1%; P = 0.001) within arsenic-exposed patients. Arsenic exposure was the only significant predictor for the presence of high-grade tumors (adjusted OR: 5.10; 95%CI: 2.03-12.77) on multivariable analysis. Conclusions: Our study revealed relevant clinical differences in bladder cancer patients with a history of arsenic exposure as compared to nonexposed cases. The more aggressive phenotype associated to arsenic-related bladder cancer should be considered when designing efficient screening strategies for this high-risk population.es_ES
Patrocinadordc.description.sponsorshipComisión Nacional de Investigación Científica y Tecnológica (CONICYT), CONICYT FONDECYT: 1120987.es_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceUrologic Oncologyes_ES
Keywordsdc.subjectUrinary bladderes_ES
Keywordsdc.subjectDrinking wateres_ES
Keywordsdc.subjectRisk factores_ES
Títulodc.titleImpact of arsenic exposure on clinicopathological characteristics of bladder cancer: a comparative study between patients from an arsenic-exposed region and nonexposed reference siteses_ES
Document typedc.typeArtículo de revistaes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES

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