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Authordc.contributor.authorMartínez, Suzanna M. 
Authordc.contributor.authorBlanco, Estela 
Authordc.contributor.authorBurrows Argote, Raquel 
Authordc.contributor.authorLozoff, Betsy 
Authordc.contributor.authorGahagan, Sheila 
Cita de ítemdc.identifier.citationPediatric Diabetes 2020;21:203–209.es_ES
Abstractdc.description.abstractBackground Obesity is a risk factor for insulin resistance (IR) and metabolic disease. Objective To examine potential metabolic pathways linking childhood weight status to adolescent IR and metabolic risk. Methods Participants were 600 low- to middle-income Chilean adolescents from a cohort studied since infancy as part of an iron deficiency anemia preventive trial and follow-up study. We examined body mass index z-score at 10 y (BMIz-10y) and blood pressure, total fat, and fasting glucose, adiponectin to leptin ratio (A:L), ghrelin, and HOMA-IR at 16 y. A total count for metabolic risk factors (MRF) was calculated using the International Diabetes Federation criteria. We used path analysis to estimate pathways and model indirect effects from BMIz-10y, controlling for child age and sex and maternal body mass index (BMI). Results Participants were 54% male; mean BMIz-10y of 0.53 (SD = 1.02); mean MRF of 1.3 (SD = 0.9); mean HOMA-IR of 1.8 (SD = 1.3). Path analysis showed that BMIz-10y directly and indirectly related to increased MRF via A:L and HOMA-IR. Ghrelin was not in the metabolic pathway from BMIz-10y to MRF but was related to MRF via HOMA-IR. Conclusion These results elucidate metabolic pathways involving child weight status, IR and metabolic risk in adolescents. Childhood BMI was an indirect risk factor for adolescent cardiometabolic risk via several pathways that involved BMI, appetite hormones, markers of inflammation, and insulin resistance during adolescence. Findings illustrate the adverse effect that childhood obesity has on adolescent health outcomes, which sets precedence for health outcomes over the life course.es_ES
Patrocinadordc.description.sponsorshipUnited States Department of Health & Human Services, National Institutes of Health (NIH) - USA, NIH National Heart Lung & Blood Institute (NHLBI): K01HL129087, R01HL088530. United States Department of Health & Human Services, National Institutes of Health (NIH) - USA, NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD): R01HD33487.es_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourcePediatric Diabeteses_ES
Keywordsdc.subjectInsulin resistancees_ES
Keywordsdc.subjectMetabolic riskes_ES
Keywordsdc.subjectWeight statuses_ES
Títulodc.titleMechanisms linking childhood weight status to metabolic risk in adolescencees_ES
Document typedc.typeArtículo de revistaes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile