New emerging roles of Polycystin-2 in the regulation of autophagy
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Polycystin-2 (PC2) is a calcium channel that can be found in the endoplasmic reticulum, the plasmatic membrane, and the primary cilium. The structure of PC2 is characterized by a highly ordered C-terminal tail with an EF-motif (calcium-binding domain) and a canonical coiled-coil domain (CCD; interaction domain), and its activity is regulated by interacting partners and post-translational modifications. Calcium mobilization into the cytosol by PC2 has been mainly associated with cell growth and differentiation, and therefore mutations or dysfunction of PC2 lead to renal and cardiac consequences. Interestingly, PC2-related pathologies are usually treated with rapamycin, an autophagy stimulator. Autophagy is an intracellular degradation process where recycling material is sequestered into autophagosomes and then hydrolyzed by fusion with a lysosome. Interestingly, several studies have provided evidence that PC2 may be required for autophagy, suggesting that PC2 maintains a physiologic catabolic state.
Comision Nacional de Investigacion y Desarrollo Tecnologico (CONICYT, Chile): FONDECYT 1160820 1171075 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) ACT172066 FONDAP 15130011 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 3200354 PEW Latin American Fellows Program in the Biomedical Science 00002991 International Centre for Genetic Engineering and Biotechnology, ICGEB CRP/CHL16-06 CONICYT PhD fellowship 21140848 Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research (KAKENHI) 21680029
Artículo de publicación ISI
Quote ItemInternational Review of Cell and Molecular Biology (2020) 354 Págs. 165-186