Browsing by Author "eec721a8-b980-4909-9125-9797e367e10d"

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    • Addicted to secrete - novel concepts and targets in cancer therapy 
      Dejeans, Nicolas; Manié, Serge; Hetz Flores, Claudio; Bard, Frédéric; Hupp, Ted; Agostinis, Patrizia; Samali, Afshin; Chevet, Eric (Elsevier Ltd, 2014)
      The unfolded protein response (UPR) mediates the adaptation of the secretory pathway (SP) to fluctuations in cellular protein demand or to environmental variations. Recently, drug screenings have confirmed the therapeutic ...
    • Dual IRE1 RNase functions dictate glioblastoma development 
      Lhomond, Stephanie; Avril, Tony; Dejeans, Nicolas; Hetz Flores, Claudio (Wiley, 2018)
      Proteostasis imbalance is emerging as a major hallmark of cancer, driving tumor aggressiveness. Evidence suggests that the endoplasmic reticulum (ER), a major site for protein folding and quality control, plays a critical ...