Now showing items 21-40 of 103

    • Núñez Vergara, Luis; Yudelevich, J.; Squella Serrano, Juan; Speisky Cosoy, Hernán (Oxford University Press, 1991)
      Acetaldehyde, at concentrations occurring in vivo was found to avidly react in vitro with several clinically relevant drugs. The greatest reactivity was observed for the hydrazine and hydrazide-containing drugs, hydralazine ...
    • Núñez Vergara, Luis; Bollo Dragnic, Soledad; Fuentealba Arcos, Jorge Patricio; Sturm Schaub, Juan; Squella Serrano, Juan (KLUWER ACADEMIC/PLENUM PUBL, 2002-04)
      Purpose. To characterize the electrochemical behavior of the photodegradation product of nifedipine, i.e., 2,6-dimethyl-4-(2-nitrosophenyl)-3,5-pyridine-carboxylic acid dimethyl ester (NPD) in different electrolytic media. ...
    • Núñez Vergara, Luis; Bontá, M.; Sturm, J. C.; Navarrete Encina, Patricio; Bollo Dragnic, Soledad; Squella Serrano, Juan (PERGAMON-ELSEVIER SCIENCE, 2001-08-31)
      This paper reports a comprehensive study by tast polarography, d.p.p., and cyclic voltammetry on the electrochemical reduction in different electrolytic media of ortho- and meta-nitrotoluene derivatives. Controlled potential ...
    • Núñez Vergara, Luis; Squella Serrano, Juan (1983)
      The a.c polarographic method has been applied in the study of the glutathione-ampicillin interaction at pH 7.4 and 37°C. Ampicillin shifted the peak potentials of glutathione to less negative values. A linear relation was ...
    • Núñez Vergara, Luis; Squella Serrano, Juan (1983)
      The a.c polarographic method has been applied in the study of the glutathione-ampicillin interaction at pH 7.4 and 37°C. Ampicillin shifted the peak potentials of glutathione to less negative values. A linear relation was ...
    • Squella Serrano, Juan; González, P.; Bollo Dragnic, Soledad; Núñez Vergara, Luis (KLUWER ACADEMIC/PLENUM PUBL, 1999-01)
    • Salazar González, Ricardo Andrés; Navarrete Encina, Patricio; Camargo Grandón, Rodrigo; Squella Serrano, Juan; Núñez Vergara, Luis (ELSEVIER SCIENCE SA, 2008-10-01)
      This work reports the electrochemical oxidation of two new synthetic C4-vanillin and -isovanillin-1,4-dihydropyridines in aprotic medium. Its reactivity with alkylperoxyl radicals ABAP-derived at pH 7.4 is also studied. ...
    • Álvarez Lueje, Alejandro; Pessoa Mahana, Hernán; Núñez Vergara, Luis; Squella Serrano, Juan (ELSEVIER SCIENCE, 1998-08)
      The electrochemical reduction of four 2,5-dimethoxy nitrobenzene 6-substituted derivatives in aqueous and mixed media by cyclic voltammetry, tast and differential pulse polarography were studied. In aqueous media, pH > 8, ...
    • Bollo Dragnic, Soledad; Gunckel, S.; Núñez Vergara, Luis; Chauviere, G.; Squella Serrano, Juan (WILEY-V C H VERLAG GMBH, 2005-02)
      The electrochemical behavior of three different megazol analogues substituted at position 4 and their comparison with the parent compound megazol in protic and aprotic media by cyclic voltarnmetry, Tast and differential ...
    • Álvarez Lueje, Alejandro; Peña, C.; Núñez Vergara, Luis; Squella Serrano, Juan (WILEY-V C H VERLAG GMBH, 1998-11)
      Flutamide, 4-nitro-3-trifluoromethyl-isobutylanilide a synthetic antiandrogenic with therapeutic use in prostatic cancer, is electrochemically studied to propose a new electroanalytical alternative for its quantitative ...
    • Bollo Dragnic, Soledad; Núñez Vergara, Luis; Soto Bustamante, Eduardo; Squella Serrano, Juan (ELSEVIER SCIENCE, 2000-09-29)
      This paper reports electrochemical (tast polarography, differential pulse polarography, cyclic voltammetry) and spectroscopic investigations covering a series of stilbene derivatives having either one or two electron-donating ...
    • Squella Serrano, Juan; Berguecio, María; Hernández, A.; Cassels Niven, Bruce; Núñez Vergara, Luis (Elsevier , Science Ltd., 1991-11-26)
      A set of 2,5-dimethoxyamphetarnines differing in their substitution at C4 was studied by differential pulse voltammetry and linear scan cyclic voltammetry in aqueous media. These experiments showed a single oxydation ...
    • Núñez Vergara, Luis; Sturm Schaub, Juan; Olea Azar, Claudio; Navarrete Encina, Patricio; Bollo Dragnic, Soledad; Squella Serrano, Juan (HARWOOD ACAD PUBL GMBH, 2000)
      This paper deals with the reactivity of the nitro radical anion electrochemically generated from nitrofurantoin with glutathione. Cyclic voltammetry (CV) and controlled potential electrolysis were used to generate the nitro ...
    • Moscoso Cabello, Raúl Andrés (Universidad de Chile, 2015)
      Los electrodos basados en nanotubos de carbono como material electródico, tienen múltiples ventajas; su bajo costo, buena conductividad eléctrica, un amplio rango de potencial, presentan actividad electro-catalítica muchas ...
    • Argüello da Silva, Jacqueline; Núñez Vergara, Luis; Squella Serrano, Juan (ELSEVIER SCIENCE, 2005-01)
      We have synthesized and studied the electroreduction of 1,4-dihydropyridine derivatives with a nitrofuryl substituent at 4-position. The one-electron reduction of these compounds in non-aqueous medium generates the ...
    • Pardo Jiménez, Viviana Gladys (Universidad de Chile, 2011)
      En la presente Memoria se hace un estudio sistemático sobre la síntesis de 9-metoxiy 9-nitro-cromenodihidropiridinas y cromenopiridinas substituídas, las cuales fueron posteriormente caracterizadas física y electroquímicamente. ...
    • Requena Alvarez, Claudia Johanna (Universidad de ChilePrograma Cybertesis, 2008)
      En esta Memoria se desarrolló una metodología por HPLC, para ser empleada en el estudio de estabilidad hidrolítica del fármaco hipocolesterolémico pravastatina. Las condiciones óptimas fueron alcanzadas luego de llevar ...
    • López Alarcón, Camilo; Squella Serrano, Juan; Núñez Vergara, Luis; Báez Guerrero, Hernán; Camargo Grandón, Rodrigo (JOHN WILEY, 2002)
      A gas chromatography/mass spectrometry (GC/MS) method for the qualitative and quantitative determination of the calcium-channel antagonists C-4-substituted 1,4-dihydropyridines, and their corresponding N-ethyl derivatives, ...
    • Zapata Urzúa, Claudio; Pérez Ortiz, Magdalena; Acosta, Gerardo A.; Mendoza, Joan; Yedra, Lluis; Estradé, Sonia; Álvarez Lueje, Alejandro; Núñez Vergara, Luis; Albericio, Fernando; Lavilla, Rodolfo; Kogan Bocian, Marcelo (Elsevier, 2015)
      Anisotropic and branched gold nanoparticles have great potential in optical, chemical and biomedical applications. However their syntheses involve multi-step protocols and the use of cytotoxic agents. Here, we report a ...
    • Álvarez Lueje, Alejandro; Sturm Schaub, Juan; Squella Serrano, Juan; Núñez Vergara, Luis (PERGAMON-ELSEVIER SCIENCE, 2002-06-01)
      The development of a new HPLC-UV diode array procedure applied to follow the hydrolytic degradation of two well-known 4-nitrophenyl-1,4-dihydropyridine derivatives, nitrendipine and nisoldipine is reported. Hydrolysis of ...