Browsing by Author "201-0427532"
Now showing items 21-27 of 27
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Hernández, Paula; Lee, Gloria; Sjoberg, Marcela; Maccioni Baraona, Ricardo (IOS PRESS, 2009)Alzheimer’s disease (AD) is characterized by the accumulation of protein filaments, namely extracellular amyloid-β (Aβ) fibrils and intracellular neurofibrillary tangles, which are composed of aggregated hyperphosphorylated ...
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Slachevsky Chonchol, Andrea; Guzman Martínez, Leonardo; Delgado Derio, Carolina; Reyes Sánchez, Pablo; Farías Gontupil, Gonzalo; Muñoz Neira, Carlos; Bravo, Eduardo; Farías, Mauricio; Flores Rodríguez, Patricia; Garrido Inostroza, Cristian; Becker, James; López, Oscar; Maccioni Baraona, Ricardo (IOS Press, 2017)Background: Intracellular neurofibrillary tangles are part of the core pathology of Alzheimer's disease (AD), which are mainly composed of hyperphosphorylated tau protein. Objectives: The purpose of this study is to ...
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Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organization Sjoberg, Marcela; Shestakova, Elena; Mansuroglu, Zeyni; Maccioni Baraona, Ricardo; Bonnefoy, Eliette (COMPANY OF BIOLOGISTS LTD, 2006-05-15)The microtubule-associated tau protein participates in the organization and integrity of the neuronal cytoskeleton. A nuclear form of tau has been described in neuronal and non-neuronal cells, which displays a nucleolar ...
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Morales, Inelia; Cerda Troncoso, Cristóbal; Andrade, Víctor; Maccioni Baraona, Ricardo (IOS Press, 2017)Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive cognitive impairment of patients, affecting around 12% of people older than 65 years old. WHO estimated that over 48.6 million all over ...
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Maccioni Baraona, Ricardo; Otth, Carola; Concha, Ilona I.; Muñoz, Juan P. (2001)A set of different protein kinases have been involved in tau phosphorylations, including glycogen synthase kinase 3b (GSK3b), MARK kinase, MAP kinase, the cyclin-dependent kinase 5 (Cdk5) system and others. The latter ...
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Cambiazo Ayala, Verónica; González, Mauricio; Isamit, Cristián; Maccioni Baraona, Ricardo (1999)Through major research advances in the study of cytoskeletal organization, an integrated view of the complexity of this system has emerged. Recent findings on the microtubule-interacting protein Mip-90, which associates ...
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Farías Roldán, Gustavo; González Canales, Mauricio; Maccioni Baraona, Ricardo (1995)A molecular characterization of tubulin and microtubule‐associated proteins (MAPs) along with their intracellular pool distributions in both unfertilized and fertilized oocytes of the trout Oncorhynchus mykiss was carried ...