Now showing items 1-20 of 319

    • Reyes Parada, Miguel; Scorza, Cecilia; Romero, Verónica; Silveira, Rodolfo; Medina, Jorge H.; Andrus, Danice; Nichols, David E.; Cassels Niven, Bruce (Springer, 1996-05-28)
      Serotonergic behavioral responses, efTects on motor activity and core temperature, and binding properties of the novel putative anxiolytic amphe!amine derivative (± )1-(2,5-dimethoxy-4-ethylthlophenyl)- 2-aminopropane ...
    • Reyes Parada, Miguel; Scorza, Cecilia; Romero, Veronica; Silveira, Rodolfo; Medina, Jorge H.; Andrus, Danice; Nichols, David E.; Cassels Niven, Bruce (Springer Verlag, 1996)
      Serotonergic behavioral responses, effects on motor activity and core temperature, and binding properties of the novel putative anxiolytic amphetamine derivative (±)1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane ...
    • Iturriaga-Vásquez, Patricio; Zapata-Torres, Gerald; Rezende, Marcos Caroli; Cassels Niven, Bruce (2004)
      The conformational preferences of a series of 1-benzyl-1,2,3,4- tetrahydroisoquinolines (norlaudanosine and coclaurine analogues) were investigated with the aid of their 1H NMR spectra and NOESY experiments, coupled with ...
    • Iturriaga-Vásquez, Patricio; Zapata Torres, Gerald Amilcar; Caroli Rezende, Marcos; Cassels Niven, Bruce (SOCIEDAD CHILENA DE QUIMICA, 2004-03)
      The conformational preferences of a series of 1-benzyl-1,2,3,4-tetrahydroisoquinolines (norlaudanosine and coclaurine analogues) were investigated with the aid of their H-1 NMR spectra and NOESY experiments, coupled with ...
    • Zapata-Torres, Gerald; Parra-Mouchet, Julia; Cassels Niven, Bruce (1998)
      The conformational properties of ten ring-methylated N-methyl- and N,N-dimethylanilines have been studied using 13C-NMR chemical shifts and spin-lattice relaxation times in CDCl3, and semi-empirical (AM1) quantum-chemical ...
    • Zapata Torres, Gerald Amilcar; Parra Mouchet, Julia; Cassels Niven, Bruce (Socieda Chilena de Quìmica, 1997-08-01)
      The conformational properties of ten ring-methylated N-methyl- and N,Ndimethylanilines have been studied using 13C-NMR chemical shifts and spin-Iattice relaxation times in CDCI3, and semi-empírical (AM1) quantum-chemical ...
    • Tadic, Dragana; Cassels Niven, Bruce; Laprévote, Olivier; Cavé, André (American Chemical Society, 1988-09-22)
      The 13C-nmr chemical shifts of onychine (l-methyl4-aza8uoren-9-one) [l] were assigned with the aid ofheternnuclear 2D-nmr spectraand these results were used to interpret the 13C nmr spectra of several other synthetic duorenones.
    • Lühr-Sierra, Susan; Vilches-Herrera, Marcelo; Fierro, Angélica; Ramsay, Rona; Edmondson, Dale E.; Reyes Parada, Miguel; Cassels Niven, Bruce; Iturriaga-Vásquez, Patricio (ELSEVIER, 2010)
      2-Arylthiomorpholine and 2-arylthiomorpholin-5-one derivatives, designed as rigid and/or non-basic phenylethylamine analogues, were evaluated as rat and human monoamine oxidase inhibitors. Molecular docking provided ...
    • Lühr, Susan; Vilches Herrera, Marcelo; Fierro, Angélica; Ramsay, Rona R.; Edmondson, Dale E.; Reyes Parada, Miguel; Cassels Niven, Bruce; Iturriaga-Vásquez, Patricio (2010)
      2-Arylthiomorpholine and 2-arylthiomorpholin-5-one derivatives, designed as rigid and/or non-basic phenylethylamine analogues, were evaluated as rat and human monoamine oxidase inhibitors. Molecular docking provided insight ...
    • Sieveking, Ivan; Thomas, Pablo; Estévez, Juan C.; Quiñones, Natalia; Cuéllar, Mauricio A.; Villena, Juan; Espinosa Bustos, Christian; Fierro, Angélica; Tapia, Ricardo A.; Maya Arango, Juan; López Muñoz, Rodrigo; Cassels Niven, Bruce; Estévez, Ramón J.; Salas, Cristian (Elsevier, 2014)
      A series of new 2-aminonaphthoquinones and related compounds were synthesized and evaluated in vitro as trypanocidal and cytotoxic agents. Some tested compounds inhibited epimastigote growth and trypomastigote viability. ...
    • Villalobos, Claudio A.; Bull, Paulina; Sáez, Patricio; Cassels Niven, Bruce; Huidobro-Toro, J. Pablo (2004)
      1 We recently described that several 2-(2,5-dimethoxy-4-substituted phenyl)ethylamines (PEAs), including 4-I = 2C-I, 4-Br = 2C-B, and 4-CH 3 = 2C-D analogs, are partial agonists at 5-HT 2C receptors, and show low or even ...
    • Villalobos, Claudio A.; Bull, Paulina; Sáez, Patricio; Cassels Niven, Bruce; Huidobro Toro, Juan Pablo (Nature Publishing Group, 2004-02-04)
      1 We recently described that several 2-(2,5-dimethoxy-4-substituted phenyl)ethylamines (PEAs), including 4-I¼2C-I, 4-Br¼2C-B, and 4-CH3¼2C-D analogs, are partial agonists at 5-HT2C receptors, and show low or even negligible ...
    • Reyes Parada, Miguel; Scorza, Ma. Cecilia; Silveira, Rodolfo; Dajas, Federico; Cassels Niven, Bruce (EIsevier Science Ltd., 1994-04-04)
      4-Dimethylaminophenethylamine (DMAPEA) was characterized as an MAO substrate. This compound was unaffected by MAO-A, while its oxidation by MAO-B was linear as a function of both time and enzyme concentration, with Km = ...
    • Reyes Parada, Miguel; Scorza, Cecilia; Silveira, Rodolfo; Dajas, Federico; Cassels Niven, Bruce (Elsevier , Science Ltd., 1994-04-04)
      4-Dimethylaminophenethylamine (DMAPEA) was characterized as an MAO substrate. This compound was unaffected by MAO-A, while its oxidation by MAO-B was linear as a function of both time and enzyme concentration, with Km = ...
    • Urzúa, A.; Cassels Niven, Bruce (Pergamon Press Ltd., 1978-05-29)
    • Toro-Sazo, Miguel; Brea, José; Loza, María I.; Cimadevila, Marta; Cassels Niven, Bruce (Public Library of Science, 2019)
      © 2019 Toro-Sazo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
    • Marder, Mariel; Viola, Haydee; Wasowski, Cristina; Wolfman, Claudia; Waterman, Peter G.; Cassels Niven, Bruce; Medina, Jorge H.; Paladini, Alejandro C. (Elsevier Inc., 1996-04-13)
      6-Bromoflavone, obtained by bromination of flavanone, binds to central benzodiazepine receptors witb a Ki =70 nM and has a clear anxiolytic activity in mice, at 0.5 mgJkg, i.p. A survey of tbe structure/affinity ...
    • Ivona, M. Dolores; Valiente, Miguel; Martínez, Sonia; Madrero, Yolanda; Noguera, M. Antonia; Cassels Niven, Bruce; Sobarzo Sánchez, Eduardo; O'Ocon, Pilar (Georg Thieme, 2005-04-13)
      5tructure-activity analysis of 21 aporphine derivatives was performed by examining their affinities for c10ned human alA. alB and alD adrenoceptors (AR) using membranes prepared from rat -1 fibroblasts stably expressing ...
    • Ivorra, M. Dolores; Valiente, Miguel; Martĩnez, Sonia; Madrero, Yolanda; Noguera, M. Antonia; Cassels Niven, Bruce; Sobarzo Sánchez, Eduardo; D'Ocon, Pilar (2005)
      Structure-activity analysis of 21 aporphine derivatives was performed by examining their affinities for cloned human α1A, α1B and α1D adrenoceptors (AR) using membranes prepared from rat-1 fibroblasts stably expressing ...
    • Negrete Córdova, Rosa; Cassels Niven, Bruce; Eckhardt, Gert (Pergamon Press Ltd., 1983-01-21)
      A new quinolizidine alkaloid, (+ )-9cx-hydroxymatrine, was isolated from the lea ves of Sophora macrocarpa. Its structure was determined by a combination of spectroscopic methods, among which nuclear Overhauser enhancement ...