Now showing items 1-8 of 8

    • Araneda Ríos, Felipe (Universidad de Chile, 2017)
      La obesidad es un problema de salud pública. Se ha demostrado el desarrollo directo de falla cardiaca secundaria, con manifestaciones clínicas precoces y sutiles, como por ejemplo una mayor frecuencia de episodios de ...
    • Pedrozo Cibils, Zully; Sánchez, G.; Torrealba, N.; Valenzuela, Rodrigo; Fernández, Carolina; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio; Donoso Laurent, Paulina (ELSEVIER SCIENCE BV, 2010-03)
      Type-2 ryanodine receptors (RyR2) - the calcium release channels of cardiac sarcoplasmic reticulum - have a central role in cardiac excitation-contraction coupling. In the heart, ischemia/reperfusion causes a rapid and ...
    • Pedrozo Cibils, Zully; Torrealba, Natalia; Fernández, Carolina; Gatica, Damián; Toro, Barbra; Quiroga, Clara; Rodríguez, Andrea E.; Sánchez, Gina; Gillette, Thomas G.; Hill, Joseph A.; Donoso Laurent, Paulina; Lavandero González, Sergio (the European Society of Cardiology, 2013)
      Aims Chaperone-mediated autophagy (CMA) is a selective mechanism for the degradation of soluble cytosolic proteins bearing the sequence KFERQ. These proteins are targeted by chaperones and delivered to lysosomes where ...
    • Donoso Laurent, Cecilia; Donoso Laurent, Paulina (2011)
      Stretching a heart muscle cell triggers signaling by reactive oxygen species to produce Ca 2+ sparks.
    • Bull Simpfendorfer, Ricardo; Finkelstein, José Pablo; Gálvez, Jorge; Sánchez, Gina; Donoso Laurent, Paulina; Behrens Pellegrino, María Isabel; Hidalgo Tapia, María Cecilia (2008)
      Cerebral ischemia stimulates Ca2+influx and thus increases neuronal intracellular free [Ca2+. Using a rat model of cerebral ischemia without recirculation, we tested whether ischemia enhances the activation by Ca2+ of ...
    • Romero Romano, Pablo (Universidad de Chile, 2017)
      Las enfermedades cardiovasculares corresponden a una de las mayores causas de muerte en el mundo, donde el infarto agudo del miocardio es responsable de la mayoría de ellas. Diferentes vías confluyen en el daño y muerte ...
    • Salas, Margarita A.; Valverde, Carlos A.; Sánchez, Gina; Said, Matilde; Rodríguez, Jesica S.; Portiansky, Enrique L.; Kaetzel, Marcia A.; Dedman, John R.; Donoso Laurent, Paulina; Kranias, Evangelia G.; Mattiazzi, Alicia (ELSEVIER, 2010)
      Ca2+-calmodulin-dependent protein kinase II (CaMKII) plays an important role mediating apoptosis/ necrosis during ischemia-reperfusion (IR). We explored the mechanisms of this deleterious effect. Langendorff perfused rat ...
    • Sánchez, Gina; Pedrozo Cibils, Zully; Domenech Lira, Raúl; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 2005-12)
      We have shown previously that electrically induced tachycardia effectively produces myocardial preconditioning. Among other effects, tachycardia increases calcium release rates in microsomal fractions enriched in sarcoplasmic ...