Browsing by Author "Leyton Campos, Lisette"
Now showing items 1-20 of 37
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(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2004-09-10)Thy-1, a cell adhesion molecule abundantly expressed in mammalian neurons, binds to a beta(3)-containing integrin on astrocytes and thereby stimulates the assembly of focal adhesions and stress fibers. Such events lead to ...
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(Frontiers Media, 2021)Astrocyte reactivity is associated with poor repair capacity after injury to the brain, where chemical and physical changes occur in the damaged zone. Astrocyte surface proteins, such as integrins, are upregulated, and the ...
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(2012)Thy-1 is a membrane glycoprotein suggested to stabilize or inhibit growth of neuronal processes. However, its precise function has remained obscure, because its endogenous ligand is unknown. We previously showed that Thy-1 ...
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(2011)Thy-1, an abundant mammalian glycoprotein, interacts with avβ3 integrin and syndecan-4 in astrocytes and thus triggers signaling events that involve RhoA and its effector p160ROCK, thereby increasing astrocyte adhesion to ...
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(NATL ACAD SCIENCES, 2006-10-10)Increased expression of casein kinase 2 (CK2) is associated with hyperproliferation and suppression of apoptosis in cancer. Mutations in the tumor suppressor APC (adenomatous polyposis coli) are frequent in colon cancer ...
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(Society of Biology of Chile, 2002)Caveolae are small, flask-shaped invaginations of the plasma membrane present on a large number of mammalian cells. Recent results obtained with knock-out mice for the gene caveolin-1 demonstrate that expression of caveolin-1 ...
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(PUBLIC LIBRARY SCIENCE, 2012-04-10)Caveolin-1 is known to promote cell migration, and increased caveolin-1 expression is associated with tumor progression and metastasis. In fibroblasts, caveolin-1 polarization and phosphorylation of tyrosine-14 are essential ...
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(Society of Biology of Chile, 2002)Cellular signaling is an area of intense research that transcends all fields of experimental biology. As such, progress in this domain will continue to have an ever-increasing impact on society in general and health-related ...
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(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2005-06-03)The β 2 integrins are found exclusively in leukocytes and they are composed of a common β chain, CD18, and one of four unique α chains, CD11a (α L subunit), CD11b (α M subunit), CD11c (α ...
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(Universidad de Chile, 2020)Las lesiones del sistema nervioso central cambian química y físicamente el entorno de las neuronas y las células gliales mediante la liberación de moléculas proinflamatorias y proteínas de la matriz extracelular, generando ...
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(Universidad de Chile, 2015)Choroidal neovascularization is the third leading cause of blindness in the western world. Its etiology remains unknown. However, it has been established that both up-regulation of VEGF and down-regulation of PEDF at the ...
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(Universidad de Chile, 2016)El cáncer corresponde a la segunda causa de muerte en Chile y el mundo, pero los pacientes con cáncer no mueren debido al crecimiento del tumor primario, sino a la diseminación de las células tumorales y posterior ...
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(BioMed Central, 2015)Background: Caveolin-1 (CAV1) has been implicated both in tumor suppression and progression, whereby the specific role appears to be context dependent. Endometrial cancer is one of the most common malignancies of the female ...
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(Universidad de Chile, 2015)Previamente describimos que la interacción entre Thy- 1 neuronal y la integrina αvβ3 presente en astrocitos aumenta la fosforilación inhibitoria de Src, provoca retracción de neuritas e inhibe el crecimiento de éstas. Sin ...
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Extracellular vesicles as mediators of cancer disease and as nanosystems in theranostic applications (MDPI, 2021)Simple Summary Cancer is the second leading cause of death in humans, and in 2020, 9.8 million cancer-related deaths were reported worldwide. In the last 20 years, it has become apparent that small vesicles released by ...
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(Universidad de Chile, 2020)El diagnóstico del cáncer ha aumentado en las últimas décadas y su mortalidad debido a la metástasis crece mundialmente. Las vesículas extracelulares (VE) contribuyen a la comunicación celular normal y patológica, como ...
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Human survivin and trypanosoma cruzi calreticulin act in synergy against a murine melanoma in vivo (2014)Immune-based anti-tumor or anti-angiogenic therapies hold considerable promise for the treatment of cancer. The first approach seeks to activate tumor antigen-specific T lymphocytes while, the second, delays tumor growth ...
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(WILEY-LISS, DIV JOHN WILEY & SONS INC, 2005-09)Objective. Previous findings in labial salivary glands (LSGs) from patients with Sjogren ' s syndrome (SS) suggest that increased activity and expression of matrix metalloproteinase 9 (MMP-9) and MMP-3 trigger the destruction ...
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(Society of Biology of Chile, 2002)In summary, formation of multi-protein complexes is an essential if not defining feature of eukaryotic signaling. Clearly, we now appreciate this fact and are beginning to grasp some of the underlying guiding principles. ...
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(2006)Objective. To investigate remodeling of the basal lamina of labial salivary glands (LSGs) from patients with Sjögren's syndrome (SS) by analyzing the expression of specific components that participate in its assembly and ...
