Browsing by Author "Martínez, Agustín D."

Now showing items 1-3 of 3

    • Histamine reduces gap junctional communication of human tonsil high endothelial cells in culture 
      Figueroa, Xavier F.; Alviña, Karina; Martínez, Agustín D.; Garcés, Gladys; Rosemblatt Silber, Mario César; Boric, Mauricio P.; Sáez, Juan C. (Academic Press Inc., 2004)
      The regulation of gap junctional communication by histamine was studied in primary cultures of human tonsil high endothelial cells (HUTECs). We evaluated intercellular communication, levels, state of phosphorylation, and ...
    • Supporting cells and their potential roles in cisplatin-induced ototoxicity 
      Waissbluth, Sofia; Maass Oñate, Juan Cristóbal; Sánchez, Helmuth A.; Martínez, Agustín D. (Frontiers Media, 2022)
      Cisplatin is a known ototoxic chemotherapy drug, causing irreversible hearing loss. Evidence has shown that cisplatin causes inner ear damage as a result of adduct formation, a proinflammatory environment and the generation ...
    • The syndromic deafness mutation G12R impairs fast and slow gating in Cx26 hemichannels 
      García, Isaac E.; Villanelo, Felipe; Contreras, Gustavo F.; Pupo, Amaury; Pinto, Bernardo I.; Contreras, Jorge E.; Pérez Acle, Tomás; Alvarez, Osvaldo; Latorre, Ramón; Martínez, Agustín D.; González, Carlos (Rockefeller University Press, 2018)
      Mutations in connexin 26 (Cx26) hemichannels can lead to syndromic deafness that affects the cochlea and skin. These mutations lead to gain-of-function hemichannel phenotypes by unknown molecular mechanisms. In this study, ...