Now showing items 1746-1765 of 2801

    • Sánchez, G.; Liberona, Leonel; Llanos Mansilla, Jorge; Sanhueza, E. M.; Giussani, Dino A.; Blanco, C. E.; Hanson, M. A.; Riquelme González, Raquel (CAMBRIDGE UNIV PRESS, 2002-10-01)
      The hypothesis that nitric oxide plays a key role in the regulation of adrenal blood flow and plasma concentrations of cortisol and catecholamines under basal and hypoxaemic conditions in the llama fetus was tested. At ...
    • Galleguillos, Marco; Valenzuela Pedevila, María Antonieta; Riquelme González, Raquel; Sanhueza, Emilia M.; Sánchez, Gina; Figueroa, Jorge P.; Llanos Mansilla, Jorge (ELSEVIER SCIENCE INC, 2001-06)
      The fetal llama (Lama glama; a species adapted to live in chronic hypoxia in the highlands of the Andes) did not increase cerebral blood flow and reduce the brain oxygen uptake during hypoxemia. Although nitric oxide (NO) ...
    • Núñez Vergara, Luis; Squella Serrano, Juan; Bollo Dragnic, Soledad; Morello Casté, Antonio; Repetto Scaramelli, Yolanda; Aldunate, Jorge; Letelier, María E. (1997)
      A series of nitro aryl 1,4-dihydropyridine derivatives produced inhibition of both cell growth and oxygen consumption on Tulahuen and LQ strains, and clone Dm 28c of epimastigotes of Trypanosoma cruzi. Nicardipine was found ...
    • Núñez Vergara, Luis; Aldunate, Jorge; Letelier Muñoz, María Eugenia; Bollo Dragnic, Soledad; Repetto Scaramelli, Yolanda; Morello Casté, Antonio; Spencer, P. L.; Squella Serrano, Juan (Elsevier, 1995)
      The cyclic voltammetric (CV) behaviour of nifurtimox was studied. The addition of aprotic solvent (DMF) to nifurtimox in an aqueous citrate buffer system was examined. Qualitatively this results in separation of the initial ...
    • Argüello da Silva, Jacqueline; Núñez Vergara, Luis; Bollo Dragnic, Soledad; Squella Serrano, Juan (ELSEVIER SCIENCE SA, 2006-09)
      Three new nitrofuryl substituted 1,4-dihydropyridine derivatives were electrochemically tested in the scope of newly found compounds useful as chemotherapeutic alternative to the Chagas' disease. All the compounds were ...
    • Bontá, M.; Chauviere, G.; Perie, J.; Núñez Vergara, Luis; Squella Serrano, Juan (PERGAMON-ELSEVIER SCIENCE, 2002-09-25)
      We have studied the electrochemical reduction of some nitroimidazoles such as megazol(2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazol, CAS 19622-55-0) and two related derivatives in aprotic media (100% DMF, 0.1 ...
    • Letelier Muñoz, María Eugenia; Entrala Alrruiz, Paz Andrea; López Alarcón, Camilo; González Lira, Víctor; Molina Berríos, Alfredo Enrique; Cortés Troncoso, Juan; Jara Sandoval, José; Santander, P.; Núñez Vergara, Luis (PERGAMON-ELSEVIER SCIENCE, 2007-12)
      1,4-Dihydropyridines (DHPs) used in the treatment of cardiovascular diseases, are calcium channel antagonists and also antioxidant agents. These drugs are metabolized through cytochrome P-450 oxidative system, majority ...
    • Urzúa, J.; Yañez, C.; Carbajo, J.; Mozo, J. D.; Squella Serrano, Juan (Elsevier, 2020)
      We describe nanostructured electrode platforms composed of multiwalled carbon nanotube/glassy carbon electrodes (MWCNT/GCEs) with entrapped nitroaromatic compounds such as 2-nitrofluorene (2-NF), 2-nitro-9- fluorenone ...
    • Gallardo Garrido, C.; Cho, Y.; Cortés Ríos, J.; Vásquez Velásquez, David; Pessoa Mahana, C. David; Araya Maturana, R.; Pessoa Mahana, Hernán; Faúndez, M. (Elsevier, 2020)
      Nitrofurans (5-nitro-2-hydrazonylfuran as pharmacophore) are a group of widely used antimicrobial drugs but also associated to a variety of side effects. The molecular mechanisms that underlie the cytotoxic effects of ...
    • Otero, Lucía; Aguirre, Gabriela; Boiani, Lucía; Denicola, Ana; Rigol Olsen, Carolina; Olea Azar, Claudio; Maya Arango, Juan; Morello Casté, Antonio; González, Mercedes; Gambino, Dinorah; Cerecetto, Hugo (ELSEVIER, 2006-11)
      Rhenium and ruthenium complexes of the type [(ReOCl2)-O-V(PPh3)L] and [(RuC2)-C-II(DMSO)(2)L], where L are 5-nitroftitylsemicarbazone derivatives, were prepared in an effort to obtain new anti-trypanosomal agents combining ...
    • Barriga González, Germán Eduardo; Aliaga, Carolina; Olea Azar, Claudio; Zúniga López, María C.; González, Mercedes; Cerecetto, Hugo (Bentham Science Publishers Ltd., 2017)
      Background: Nowadays, nitrones are the most used spin traps to characterize free radicals in biological systems due to the versatility and variety depending on the types of radicals to study and that the half-lives of the ...
    • Merino, M.; Carbajo, J.; Núñez Vergara, Luis; Squella Serrano, Juan (SOCIEDAD CHILENA DE QUIMICA, 2000-03)
      The electrochemical nitroreduction of nitrofurantoin has been studied on carbon paste and glassy carbon electrodes. We can observe a monoelectronic reversible couple ArNO2/ArNO2- and an irreversible peak due to the further ...
    • Bollo Dragnic, Soledad; Núñez Vergara, Luis; Barrientos Vargas, Claudia Marjorie; Squella Serrano, Juan (WILEY-V C H VERLAG GMBH, 2005-09)
      The electrochemical behavior of iodo nitroimidazole derivatives such as 1-methyl-4-iodo-5-nitroimidazole (M-I-NIm) and 1-methyl-2,4-diiodo-5-nitroimidazole (M-I-2-NIm) and the parent compound 1-methyl-5-nitroimidazole ...
    • Núñez Vergara, Luis; Squella Serrano, Juan; Olea Azar, Claudio; Bollo Dragnic, Soledad; Navarrete Encina, Patricio; Sturm Schaub, Juan (PERGAMON-ELSEVIER SCIENCE, 2000)
      This paper reports both the electrochemical characterization and the reactivity of the nitroso radical anion from nitrosobenzene with glutathione. The reduction of nitrosobenzene to the corresponding nitroso radical anion ...
    • Palomera Gómez, Cristián Alejandro; Ocaranza, María Paz; Román, Maritza; Chiong Lay, Mario; Lavandero González, Sergio; Jalil Milad, Jorge (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2003)
      La mayor actividad de la enzima convertidora de angiotensina I (ECA) determina mayores niveles de angiotensina (Ang) II y menores de Ang-(1-7). Hemos observado mayores niveles de Ang II en ratas normotensas con mayor ...
    • Folch Cano, Christian; Guerrero, Juan; Speisky Cosoy, Hernán; Jullian Matthaei, Carolina; Olea Azar, Claudio (Springer, 2013)
      The present study is focused on the characterization of the interaction between (-)-epigallocatechingallate (EGCG) and cyclodextrins like b-cyclodextrin (bCD), heptakis(2,6 di-O-methyl)-b-cyclodextrin (DMbCD), ...
    • Folch Cano, Christian; Guerrero, Juan; Speisky Cosoy, Hernán; Jullian Matthaei, Carolina; Olea Azar, Claudio (2014)
      The present study is focused on the characterization of the interaction between (-)-epigallocatechingallate (EGCG) and cyclodextrins like β-cyclodextrin (βCD), heptakis(2,6 di-O-methyl)-β-cyclodextrin (DMβCD), and ...
    • Acuña Rougier, C.; Mera-Adasme,; Jullian,; Olea Azar, Claudio (2010)
      The complexes formed by (±)-4′-hydroxyflavanone (OHFL) and heptakis-(2,6-O-dimethyl)-β-cyclodextrin (DM-β-CD) were obtained using the racemic mixture of OHFL. These complexes were able to be studied due to their ...
    • Acuña Rougier, C.; Jullian,; Olea Azar, Claudio (2012)
      Complexes formed by (±)-4′-hydroxyflavanone (OHFL) and the cyclodextrins β-cyclodextrin and (2-hydroxypropyl)-β-CD were obtained using the racemic mixture of the OHFL. These complexes were able to be studied due to their ...
    • Capparelli, Mario V.; DeSanctis, Y.; Arce, A. J.; Spodine Spiridonova, Evgenia (MUNKSGAARD INT PUBL LTD, 1997-03-15)
      The reaction of 1,2,3-triphenylphosphirene with [H2Os3-(CO)(10)] leads to the title compound, [Os-3(CO)(9){(C6H5)(3)-C2PO}], which displays an open Os-3(CO)(9) cluster [Os-Os 2.703(1) and 2.867(2) Angstrom, and Os-Os-Os ...