Now showing items 1211-1230 of 2731

    • Sapag Muñoz de la Peña, Amalia; Irarrázaval Aguilera, Thergiorg; Lobos González, Lorena; Muñoz Brauning, Carlos; Quintanilla González, María Elena; Tampier de Jong, Lutske (Nature Publishing Group, 2016)
      Ribozyme genes were designed to reduce voluntary alcohol drinking in a rat model of alcohol dependence. Acetaldehyde generated from alcohol in the liver is metabolized by the mitochondrial aldehyde dehydrogenase (ALDH2) ...
    • Cancino Rivera, Patricio Antonio; Astudillo, Luis; Rovirosa, Juana; San Martín Barrientos, Aurelio (1987)
    • Zapata Urzúa, Claudio; Pérez Ortiz, Magdalena; Acosta, Gerardo A.; Mendoza, Joan; Yedra, Lluis; Estradé, Sonia; Álvarez Lueje, Alejandro; Núñez Vergara, Luis; Albericio, Fernando; Lavilla, Rodolfo; Kogan Bocian, Marcelo (Elsevier, 2015)
      Anisotropic and branched gold nanoparticles have great potential in optical, chemical and biomedical applications. However their syntheses involve multi-step protocols and the use of cytotoxic agents. Here, we report a ...
    • Yañez Valdés, María Francisca (2014)
      We present a unified approach to the study of Radon transforms related to symmetric groups and to general linear groups GLn(q), regarded as q−analogues of the former. In both cases, we define a sequence of generalized ...
    • Toledo, Carla; Enríquez, Pedro; Garrido, Mariano; Fernández-Band, Beatríz; Richter Duk, Pablo (TAYLOR & FRANCIS INC, 2010)
      A headspace-mass spectrometry with alternative chromatographic separation using a column switching system was developed for the screening and confirmation of BTEX and styrene in comestible oils. According to the position ...
    • García, Vivian; Uribe, Elsa; Vega Gálvez, Antonio; Delporte Vergara, Carla; Valenzuela Barra, Gabriela; López, Jéssica; Pasten, Alexis (Sociedad Chilena de Nutrición, 2020)
      The aim of this study was to evaluate the antioxidant, antidiabetic, anti-inflammatory and antimicrobial activities of three edible seaweed extracts from Chilean coasts: Pyropia orbicularis, Ulva spp, and Durvillaea ...
    • Riedel, Clement; Gabizon, Ronen; Wilson Moya, Christian; Hamadani, Kambiz; Tsekouras, Konstantinos; Marqusee, Susan; Presse, Steve; Bustamante, Carlos (Macmillan, 2015)
      Recent studies have shown that the diffusivity of enzymes increases in a substrate-dependent manner during catalysis1,2. Although this observation has been reported and characterized for several different systems3–10, ...
    • Schalscha B., Eduardo; Ahumada Torres, Aída Inés de Lourdes (PERGAMON-ELSEVIER SCIENCE LTD, 1998)
      Industrial and domestic waste waters in Chile are discharged without previous treatment into rivers and other inland waters which are used to irrigate agricultural lands. The present study reports on results obtained when ...
    • Valenzuela, Manuel A.; Canales, Jimena; Corvalán, Alejandro H.; Quest, Andrew F. G. (Baishideng Publishing Group Inc., 2015)
      The sequence of events associated with the development of gastric cancer has been described as "the gastric precancerous cascade". This cascade is a dynamic process that includes lesions, such as atrophic gastritis, ...
    • Calderón, Inés; Lobos, S.; Mora, Guido C. (Springer-Verlag, 1984)
      Two outer membrane proteins of Salmonella typhi T y 2 were extensively co-purified. According to their migration in dodecyl sulfate/polyacrylamide gel electrophoresis and solubility characteristics, these proteins are ...
    • Olivares Silva, Francisco Javier; Landaeta, Rodolfo; Aránguiz, Pablo; Bolivar, Samir; Humeres Martínez, Claudio; Anfossi, Renatto; Vivar Sánchez, Raúl; Boza Fuentes, Pía; Muñoz Jofré, Claudia; Pardo Jiménez, Viviana Gladys; Peiro, Concepción; Sánchez Ferrer, Carlos; Díaz Araya, Guillermo (Elsevier, 2018)
      Cardiac fibroblasts (CF) act as sentinel cells responding to chemokines, cytokines and growth factors released in cardiac tissue in cardiac injury events, such as myocardial infarction (MI). Cardiac injury involves the ...
    • Mena, Natalia P.; Esparza, Andrés; Tapia, Victoria; Valdés, Pamela; Núñez González, Marco (2007)
      Hepcidin (Hepc) is considered a key mediator in iron trafficking. Although the mechanism of Hepc action in macrophages is fairly well established, much less is known about its action in intestinal cells, one of the main ...
    • Letelier, María E.; Iturra Montecinos, Pablo; Gallardo Garrido, Carlos (Universidad de Santiago de Chile, 2017)
      Inflammation is a cellular defensive mechanism associated to oxidative stress. The administration of nitrofurantoin, nifurtimox and acetaminophen generates oxidative stress by their biotransformation through CYP450 system. ...
    • Paredes, Felipe; Parra, Valentina; Torrealba, Natalia; Navarro Márquez, Mario F.; Gatica, Damián; Bravo Sagua, Roberto; Troncoso, Rodrigo; Pennanen, Christian; Quiroga, Clara; Chiong Lay, Mario; Caesar, Christa; Taylor, W. Robert; Molgó, Jordi; San Martín, Alejandra; Jaimovich Pérez, Enrique; Lavandero González, Sergio (Elsevier, 2016)
      Homocysteine-inducible, endoplasmic reticulum (ER) stress-inducible, ubiquitin-like domain member 1 (HERPUD1), an ER resident protein, is upregulated in response to ER stress and Ca2(+) homeostasis deregulation. HERPUD1 ...
    • Navarro Márquez, Mario F.; Torrealba, Natalia; Troncoso, Rodrigo; Vásquez Trincado, César; Rodríguez, Marcelo; Morales, Pablo E.; Villalobos, Elisa; Eura, Yuka; García Nannig, Lorena; Chiong Lay, Mario; Klip, Amira; Jaimovich Pérez, Enrique; Kokame, Koichi; Lavandero González, Sergio (Elsevier, 2018)
      Skeletal muscle plays a central role in insulin-controlled glucose homeostasis. The molecular mechanisms related to insulin resistance in this tissue are incompletely understood. Herpud1 is an endoplasmic reticulum membrane ...
    • Porcal, Williams; Hernández, Paola; González, Mercedes; Ferreira, Ana; Olea Azar, Claudio; Cerecetto, Hugo; Castro, Ana (American Chemical Society, 2008-09)
      New 1,2,4-thiadiazolylnitrones and furoxanylnitrones were developed and evaluated as neuroprotective agents on a human neuroblastoma (SH-SY5Y) cells model. They inhibited at low micromolar concentrations the oxidative ...
    • Martínez Cifuentes, Maximiliano; Weiss López, Boris; Santos, Leonardo S.; Araya Maturana, Ramiro (Bentham Science Publishers B.V., 2015)
      © 2015, Bentham Science Publishers. Curcumin, a natural yellow polyphenol, is isolated from the herb Curcuma longa L. (turmeric), a member of the ginger family. It has been extensively studied due to their multiple ...
    • Martins Alho, Miriam A.; Baggio, Ricardo; Garland, María Teresa; D'Accorso, Norma B.; Varela, Oscar (2002)
      Both thiosemicarbazone groups of the derivative 1 of 3-deoxy-D-erythro-hexos-2-ulose underwent, on acetylation, a heterocyclization process to give (5R,5′R)-2,2′-diacetamido-4,4′-di-N-acetyl-5′-(1- deoxy-2,3,4-tri-O-acet ...
    • Brain Isasi, Stephanie; Álvarez Lueje, Alejandro; Higgins, Thomas Joseph V. (BioMed Central, 2017-06-15)
      Background: Phaseolamin or alpha-amylase inhibitor 1 (alpha AI) is a glycoprotein from common beans (Phaseolus vulgaris L.) that inhibits some insect and mammalian alpha-amylases. Several clinical studies support the ...
    • Larraín Barth, María Angélica; Díaz, Nelson F.; Lamas, Carmen; Uribe, Carla; Jilberto, Felipe; Araneda Tolosa, Cristian (PUCV, 2015)
      Mussels (Mytilus spp.) are one of the most cultivated and commercialized bivalves in southern Chile; culture is currently supplied almost entirely from wild-caught seed obtained from relatively few collection centers. The ...