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Authordc.contributor.authorReyes Parada, Miguel 
Authordc.contributor.authorScorza, Cecilia 
Authordc.contributor.authorRomero, Veronica 
Authordc.contributor.authorSilveira, Rodolfo 
Authordc.contributor.authorMedina, Jorge H. 
Authordc.contributor.authorAndrus, Danice 
Authordc.contributor.authorNichols, David E. 
Authordc.contributor.authorCassels Niven, Bruce 
Admission datedc.date.accessioned2018-12-20T14:32:10Z
Available datedc.date.available2018-12-20T14:32:10Z
Publication datedc.date.issued1996
Cita de ítemdc.identifier.citationNaunyn-Schmiedeberg's Archives of Pharmacology, Volumen 354, Issue 5, 2018, Pages 579-585
Identifierdc.identifier.issn00281298
Identifierdc.identifier.other10.1007/BF00170831
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/156301
Abstractdc.description.abstractSerotonergic behavioral responses, effects on motor activity and core temperature, and binding properties of the novel putative anxiolytic amphetamine derivative (±)1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2), were examined in rodents in order to elucidate the mechanism underlying its anxiolytic-like effect. After peripheral administration in rats, ALEPH-2 induced some symptoms of the serotonergic syndrome, e.g. forepaw treading and flat body posture. Additionally, a decrease in motor activity was observed. No significant effects on the number of head shakes were observed after injection, although high inter-subject variability was noted. Higher doses of ALEPH-2, in the range exhibiting anxiolytic properties (4 mg/kg), elicited significant hypothermia in mice. The affinity of the drug for 5-HT(2A/2C) receptors ([3H]ketanserin sites) was in the nanomolar range (K(i) = 173 nM), whereas for 5-HT(1A), benzodiazepine sites, and GABA(A) receptors, the affinity was micromolar
Lenguagedc.language.isoen
Publisherdc.publisherSpringer Verlag
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceNaunyn-Schmiedeberg's Archives of Pharmacology
Keywordsdc.subjectALEPH-2
Keywordsdc.subjectAnxiolytics
Keywordsdc.subjectHypothermia
Keywordsdc.subjectPhenylisopropylamines
Keywordsdc.subjectPsychedelics
Keywordsdc.subjectRat
Keywordsdc.subjectSerotonin receptor binding
Keywordsdc.subjectSerotonin syndrome
Títulodc.title(±)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-aminopropane (ALEPH-2), a novel putative anxiolytic agent lacking affinity for benzodiazepine sites and serotonin-1A receptors
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile