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Authordc.contributor.authorGatica, Damiáln 
Authordc.contributor.authorChiong Lay, Mario 
Authordc.contributor.authorLavandero González, Sergio 
Authordc.contributor.authorKlionsky, Daniel J. 
Admission datedc.date.accessioned2019-03-15T16:09:09Z
Available datedc.date.available2019-03-15T16:09:09Z
Publication datedc.date.issued2015
Cita de ítemdc.identifier.citationCirculation Research, Volumen 116, Issue 3, 2018, Pages 456-467
Identifierdc.identifier.issn15244571
Identifierdc.identifier.issn00097330
Identifierdc.identifier.other10.1161/CIRCRESAHA.114.303788
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/166429
Abstractdc.description.abstract© 2015 American Heart Association, Inc. Autophagy is a catabolic recycling pathway triggered by various intra-or extracellular stimuli that is conserved from yeast to mammals. During autophagy, diverse cytosolic constituents are enveloped by double-membrane vesicles, autophagosomes, which later fuse with lysosomes or the vacuole to degrade their cargo. Dysregulation in autophagy is associated with a diverse range of pathologies including cardiovascular disease, the leading cause of death in the world. As such, there is great interest in identifying novel mechanisms that govern the cardiovascular response to disease-related stress. First described in failing hearts, autophagy within the cardiovascular system has been characterized widely in cardiomyocytes, cardiac fibroblasts, endothelial cells, and vascular smooth muscle cells. In all cases, a window of optimal autophagic activity seems to be critical to the maintenance of cardiovascular homeostasis and function; excessive or insuffici
Lenguagedc.language.isoen
Publisherdc.publisherLippincott Williams and Wilkins
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceCirculation Research
Keywordsdc.subjectAtherosclerosis
Keywordsdc.subjectBlood vessels
Keywordsdc.subjectCardiac
Keywordsdc.subjectCardiovascular diseases
Keywordsdc.subjectHeart
Keywordsdc.subjectIntracellular signaling proteins
Keywordsdc.subjectMuscle
Keywordsdc.subjectMyocytes
Keywordsdc.subjectSmooth
Keywordsdc.subjectVascular
Títulodc.titleMolecular mechanisms of autophagy in the cardiovascular system
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile