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Authordc.contributor.authorDissen, G. A. 
Authordc.contributor.authorLara Peñaloza, Hernán 
Authordc.contributor.authorFahrenbach, W. H. 
Authordc.contributor.authorCosta, M. E. 
Authordc.contributor.authorOjeda, S. R. 
Admission datedc.date.accessioned2019-03-18T11:55:03Z
Available datedc.date.available2019-03-18T11:55:03Z
Publication datedc.date.issued1994
Cita de ítemdc.identifier.citationEndocrinology, Volumen 134, Issue 3, 2018, Pages 1146-1154
Identifierdc.identifier.issn19457170
Identifierdc.identifier.issn00137227
Identifierdc.identifier.other10.1210/endo.134.3.8119153
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/166918
Abstractdc.description.abstractWhen the ovaries of 23-day-old juvenile rats are transplanted to an ectopic site, they recover within 1 week the ability to control gonadotropin secretion via steroid negative feedback. Vascular corrosion casting followed by scanning electron microscopy revealed that the transplanted ovary becomes profusely revascularized within 48 h after transplantation. Vascular ingrowth was accompanied by a 40– to 60–fold increase in expression of the genes encoding two angiogenic factors, vascular endothelial growth factor (VEGF) and transforming growth factor-²1 (TGF ² 1), as assessed by RNA blot hybridization of the corresponding mRNAs. Although TGF ² 3 mRNA levels also increased, no changes in the levels of mRNAs encoding other putative angiogenic factors, such as TGF ±, basic fibroblast growth factor, and TGF ² 2, were observed. Hybridization histochemistry demonstrated that in intact ovaries, VEGF mRNA is mainly expressed in granulosa cells of the cumulus oophorus and thecal cells of large an
Lenguagedc.language.isoen
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceEndocrinology
Keywordsdc.subjectEndocrinology
Títulodc.titleImmature rat ovaries become revascularized rapidly after autotransplantation and show a gonadotropin-dependent increase in angiogenic factor gene expression
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile