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Authordc.contributor.authorDurán Aniotz, Claudia 
Authordc.contributor.authorCornejo, Victor Hugo 
Authordc.contributor.authorEspinoza, Sandra 
Authordc.contributor.authorArdiles, Álvaro O. 
Authordc.contributor.authorMedinas Bilches, Danilo 
Authordc.contributor.authorSalazar, Claudia 
Authordc.contributor.authorFoley, Andrew 
Authordc.contributor.authorGajardo, Ivana 
Authordc.contributor.authorThielen, Peter 
Authordc.contributor.authorIwawaki, Takao 
Authordc.contributor.authorScheper, Wiep 
Authordc.contributor.authorSoto, Claudio 
Authordc.contributor.authorPalacios, Adrian G. 
Authordc.contributor.authorHoozemans, Jeroen J.M. 
Authordc.contributor.authorHetz Flores, Claudio 
Cita de ítemdc.identifier.citationActa Neuropathologica, Volumen 134, Issue 3, 2018, Pages 489-506
Abstractdc.description.abstract© 2017, Springer-Verlag Berlin Heidelberg. Altered proteostasis is a salient feature of Alzheimer’s disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress and abnormal protein aggregation. ER stress triggers the activation of the unfolded protein response (UPR), a signaling pathway that enforces adaptive programs to sustain proteostasis or eliminate terminally damaged cells. IRE1 is an ER-located kinase and endoribonuclease that operates as a major stress transducer, mediating both adaptive and proapoptotic programs under ER stress. IRE1 signaling controls the expression of the transcription factor XBP1, in addition to degrade several RNAs. Importantly, a polymorphism in the XBP1 promoter was suggested as a risk factor to develop AD. Here, we demonstrate a positive correlation between the progression of AD histopathology and the activation of IRE1 in human brain tissue. To define the significance of the UPR to AD, we targeted IRE1 expression in a transgenic mous
Publisherdc.publisherSpringer Verlag
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.uri
Sourcedc.sourceActa Neuropathologica
Keywordsdc.subjectAlzheimer’s disease
Keywordsdc.subjectAmyloid β
Keywordsdc.subjectEndoplasmic reticulum stress
Keywordsdc.subjectProteostasis impairment
Keywordsdc.subjectUnfolded protein response
Títulodc.titleIRE1 signaling exacerbates Alzheimer’s disease pathogenesis
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación SCOPUS

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile