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Authordc.contributor.authorGarcía Miguel, Marina 
Authordc.contributor.authorRiquelme, Jaime A. 
Authordc.contributor.authorNorambuena Soto, Ignacio 
Authordc.contributor.authorMorales, Pablo E. 
Authordc.contributor.authorSanhueza Olivares, Fernanda 
Authordc.contributor.authorNúñez Soto, Constanza Belén 
Authordc.contributor.authorMondaca Ruff, David 
Authordc.contributor.authorCancino Arenas, Nicole 
Authordc.contributor.authorSan Martín, Alejandra 
Authordc.contributor.authorChiong Lay, Mario 
Admission datedc.date.accessioned2019-03-18T12:02:14Z
Available datedc.date.available2019-03-18T12:02:14Z
Publication datedc.date.issued2018
Cita de ítemdc.identifier.citationPLoS ONE, Volumen 13, Issue 5, 2018,
Identifierdc.identifier.issn19326203
Identifierdc.identifier.other10.1371/journal.pone.0197210
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/167458
Abstractdc.description.abstractThis is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Vascular smooth muscle cells (VSMC) dedifferentiation from a contractile to a synthetic phenotype contributes to atherosclerosis. Atherosclerotic tissue has a chronic inflammatory component with high levels of tumor necrosis factor-α (TNF-α). VSMC of atheromatous plaques have increased autophagy, a mechanism responsible for protein and intracellular organelle degradation. The aim of this study was to evaluate whether TNF-α induces phenotype switching of VSMCs and whether this effect depends on autophagy. Rat aortic Vascular smooth A7r5 cell line was used as a model to examine the phenotype switching and autophagy. These cells were stimulated with TNF-α 100 ng/mL. Autophagy was determined by measuring LC3-II and p62 protei
Lenguagedc.language.isoen
Publisherdc.publisherPublic Library of Science
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourcePLoS ONE
Keywordsdc.subjectBiochemistry, Genetics and Molecular Biology (all)
Keywordsdc.subjectAgricultural and Biological Sciences (all)
Títulodc.titleAutophagy mediates tumor necrosis factor-α-induced phenotype switching in vascular smooth muscle A7r5 cell line
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile