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Authordc.contributor.authorHevia, Daniel 
Authordc.contributor.authorAraos, Patricio 
Authordc.contributor.authorRíos del Prado, Carolina Alejandra 
Authordc.contributor.authorLuppichini, Eugenia Fuentes 
Authordc.contributor.authorRojas, MacArena 
Authordc.contributor.authorAlzamora, Rodrigo 
Authordc.contributor.authorCifuentes-Araneda, Flavia 
Authordc.contributor.authorGonzález, Alexis A. 
Authordc.contributor.authorAmador, Cristian A. 
Authordc.contributor.authorPacheco, Rodrigo 
Authordc.contributor.authorMichea Acevedo, Luis 
Admission datedc.date.accessioned2019-03-18T12:03:17Z
Available datedc.date.available2019-03-18T12:03:17Z
Publication datedc.date.issued2018
Cita de ítemdc.identifier.citationHypertension, Volumen 71, Issue 4, 2018, Pages 709-718
Identifierdc.identifier.issn15244563
Identifierdc.identifier.issn0194911X
Identifierdc.identifier.other10.1161/HYPERTENSIONAHA.117.10145
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/167584
Abstractdc.description.abstract© 2017 The Authors.Increasing evidence shows that antigen-presenting cells (APCs) are involved in the development of inflammation associated to hypertension. However, the potential role of APCs in the modulation of renal sodium transport has not been addressed. We hypothesized that APCs participate in renal sodium transport and, thus, development of high blood pressure in response to angiotensin II plus a high-salt diet. Using transgenic mice that allow the ablation of CD11chigh APCs, we studied renal sodium transport, the intrarenal renin-angiotensin system components, blood pressure, and cardiac/renal tissue damage in response to angiotensin II plus a high-salt diet. Strikingly, we found that APCs are required for the development of hypertension and that the ablation/restitution of APCs produces rapid changes in the blood pressure in mice with angiotensin II plus a high-salt diet. Moreover, APCs were necessary for the induction of intrarenal renin-angiotensin system components and af
Lenguagedc.language.isoen
Publisherdc.publisherLippincott Williams and Wilkins
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Sourcedc.sourceHypertension
Keywordsdc.subjectAngiotensin II
Keywordsdc.subjectAntigen-presenting cells
Keywordsdc.subjectEpithelial sodium channel
Keywordsdc.subjectHypertension
Keywordsdc.subjectInflammation
Títulodc.titleMyeloid CD11c+ antigen-presenting cells ablation prevents hypertension in response to angiotensin II plus high-salt diet
Document typedc.typeArtículo de revista
Catalogueruchile.catalogadorSCOPUS
Indexationuchile.indexArtículo de publicación SCOPUS
uchile.cosechauchile.cosechaSI


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile