Browsing by Author "01a6a971-731d-40c4-9037-49194b67c804"

Now showing items 1-9 of 9

    • Calcium/calmodulin-dependent protein kinase type IV Is a target gene of the Wnt/β-catenin signaling pathway 
      Arrázola, Macarena S.; Varela Nallar, Lorena; Colombres, Marcela; Toledo, Enrique M.; Cruzat, Fernando; Pavez, Leonardo; Assar, Rodrigo; Aravena, Andrés; González, Mauricio; Montecino, Martín; Maass Sepúlveda, Alejandro; Martínez Aguilera, Servet; Inestrosa, Nibaldo C. (2009)
      Calcium/calmodulin-dependent protein kinase IV (CaMKIV) plays a key role in the regulation of calcium-dependent gene expression. The expression of CaMKIV and the activation of CREB regulated genes are involved in memory ...
    • CDK5 downregulation enhances synaptic plasticity 
      Posada Duque, Rafael; Ramírez, Omar A.; Härtel, Steffen; Inestrosa, Nibaldo C.; Bodaleo, Felipe; González Billault, Christian; Kirkwood, Alfredo; Cardona Gómez, Gloria (Birkhauser Verlag AG, 2017)
      © 2016, Springer International Publishing. CDK5 is a serine/threonine kinase that is involved in the normal function of the adult brain and plays a role in neurotransmission and synaptic plasticity. However, its over-regulation ...
    • Cholinergic abnormalities, endosomal alterations and up-regulation of nerve growth factor signaling in ... 
      Cabeza, Carolina; Figueroa, Alicia; Lazo, Oscar M.; Galleguillos, Carolina; Pissani, Claudia; Klein, Andrés; González Billault, Christian; Inestrosa, Nibaldo C.; Alvarez, Alejandra R.; Zanlungo, Silvana; Bronfman, Francisca (2012)
      Background: Neurotrophins and their receptors regulate several aspects of the developing and mature nervous system, including neuronal morphology and survival. Neurotrophin receptors are active in signaling endosomes, which ...
    • Frizzled-1 receptor regulates adult hippocampal neurogenesis 
      Mardones, Muriel D.; Andaur, Gabriela A.; Varas Godoy, Manuel; Henriquez, Jenny F.; Salech Morales, Felipe; Behrens Pellegrino, María Isabel; Couve Correa, Andrés; Inestrosa, Nibaldo C.; Varela Nallar, Lorena (BioMed Central Ltd., 2016)
      © 2016 Mardones et al. Background: In the adult hippocampus new neurons are continuously generated from neural stem cells (NSCs) present at the subgranular zone of the dentate gyrus. This process is controlled by Wnt ...
    • Overexpression of amyloid precursor protein increases copper content in HEK293 cells 
      Suazo, Miriam; Hodar, Christian; Morgan, Carlos; Cerpa, Waldo; Cambiazo, Verónica; Inestrosa, Nibaldo C.; Gonzalez, Mauricio (2009)
      Amyloid precursor protein (APP) is a transmembrane glycoprotein widely expressed in mammalian tissues and plays a central role in Alzheimer's disease. However, its physiological function remains elusive. Cu2+ binding and ...
    • PC12 and neuro 2a cells have different susceptibilities to acetylcholinesterase-amyloid complexes, amyloid25-35 ... 
      Calderón, Frances H.; Bonnefont, Andrea; Muñoz, Francisco J.; Fernández, Virginia; Videla Cabrera, Luis; Inestrosa, Nibaldo C. (1999)
      This work addresses the differential effects of several oxidative insults on two neuronal cell lines, PC12 and Neuro 2a cells, extensively used as neuronal models in vitro. We measured cellular damage using the cytotoxic ...
    • Platelet of Alzheimer patients: Increased counts and subnormal uptake and accumulation of [14C]5-hydroxytryptamine 
      Inestrosa, Nibaldo C.; Alarcón, Rodrigo; Arriagada, Jorge; Donoso, Archibaldo; Alvarez, Jaime (1993)
      Platelets are the main source of 5-hydroxytryptamine (5-HT) and amyloid precursor protein (APP) found in plasma. We studied a possible correlation between platelet markers and the clinical diagnosis of Alzheimer disease ...
    • The synaptic protein neuroligin-1 interacts with the amyloid β-peptide. is there a role in Alzheimer's disease? 
      Dinamarca, Margarita C.; Weinstein, David; Monasterio Opazo, Octavio; Inestrosa, Nibaldo C. (2011)
      Amyloid β-peptide (Aβ) is the main component of the amyloid plaques associated with Alzheimer's disease (AD). In the early steps of the disease soluble Aβ oligomers are produced. According to the current "amyloid hypothesis" ...
    • Vitamin E but not 17β-estradiol protects against vascular toxicity induced by β-amyloid wild type and the ... 
      Muñoz, Francisco J.; Opazo, Carlos; Gil-Gómez, Gabriel; Tapia, Gladys; Fernández, Virginia; Valverde, Miguel A.; Inestrosa, Nibaldo C. (2002)
      Amyloid β-peptide (Aβ) fibril deposition on cerebral vessels produces cerebral amyloid angiopathy that appears in the majority of Alzheimer's disease patients. An early onset of a cerebral amyloid angiopathy variant called ...