Browsing by Author "05445993-124b-4856-8d2e-d9b4f04fe181"

Now showing items 1-7 of 7

    • 2-Arylthiomorpholine derivatives as potent and selective monoamine oxidase B inhibitors 
      Lühr, Susan; Vilches Herrera, Marcelo; Fierro, Angélica; Ramsay, Rona R.; Edmondson, Dale E.; Reyes Parada, Miguel; Cassels Niven, Bruce; Iturriaga-Vásquez, Patricio (2010)
      2-Arylthiomorpholine and 2-arylthiomorpholin-5-one derivatives, designed as rigid and/or non-basic phenylethylamine analogues, were evaluated as rat and human monoamine oxidase inhibitors. Molecular docking provided insight ...
    • 4-Methylthioamphetamine Increases Dopamine in the Rat Striatum and has Rewarding Effects In Vivo 
      Sotomayor Zárate, Ramón; Quiroz, Gabriel; Araya, Katherine A.; Abarca, Jorge; Ibáñez, María R.; Montecinos, Alejandro; Guajardo, Carlos; Núñez, Gabriel; Fierro, Angélica; Moya, Pablo R.; Iturriaga-Vásquez, Patricio; Gómez-Molina, Cristóbal; Gysling, Katia; Reyes Parada, Miguel (2012)
      4-Methylthioamphetamine (MTA) is a phenylisopropylamine derivative whose use has been associated with severe intoxications. MTA is usually regarded as a selective serotonin-releasing agent. Nevertheless, previous data have ...
    • Effect of alpha lipoic acid on leukotriene A4 hydrolase 
      Torres, María José; Fierro, Angélica; Pessoa Mahana, Carlos David; Romero Parra, Javier; Cabrera Vallejos, Gonzalo; Faúndez, Mario (Elsevier, 2017)
      Leukotriene A(4) hydrolase is a soluble enzyme with epoxide hydrolase and aminopeptidase activities catalysing the conversion of leukotriene A(4) to leukotriene B-4 and the hydrolysis of the peptide proline-glycine-proline. ...
    • Functional roles of T3.37 and S5.46 in the activation mechanism of the dopamine D1 receptor 
      Hugo, Estefanía A.; Cassels Niven, Bruce; Fierro, Angélica (Springer Verlag, 2017)
      © 2017, Springer-Verlag Berlin Heidelberg. The activation mechanism of dopamine receptors is unknown. The amino acids S5.42, S5.43, and S5.46 located in helix 5 appear to be crucial, but their specific roles in receptor ...
    • MAO inhibition by arylisopropylamines: The effect of oxygen substituents at the β-position 
      Osorio Olivares, Mauricio; Rezende, Marcos Caroli; Sepúlveda Boza, Silvia; Cassels Niven, Bruce; Fierro, Angélica (2004)
      Twenty-nine arylisopropylamines, substituted at the β-position of their side chain by an oxo, hydroxy, or methoxy group, were evaluated in vitro as MAO-A and MAO-B inhibitors. The oxo derivatives ('cathinones') were in ...
    • Sulfur-substituted α-alkyl phenethylamines as selective and reversible MAO-A inhibitors: Biological activities, ... 
      Gallardo Godoy, Alejandra; Fierro, Angélica; McLean, Thomas; Castillo, Mariano; Cassels Niven, Bruce; Reyes Parada, Miguel; Nichols, David (2005)
      A series of phenethylamine derivatives with various ring substituents and with or without N-methyl and/or C-alpha methyl or ethyl groups was synthesized and assayed for their ability reversibly to inhibit monoamine oxidase ...
    • Why p-OMe- and p-Cl-beta-Methylphenethylamines Display Distinct Activities uponMAO-B Binding 
      Fierro, Angélica; Edmondson, Dale E.; Celis Barros, Cristian; Rebolledo Fuentes, Marco; Zapata Torres, Gerald (Public Library Science, 2016)
      Despite their structural and chemical commonalities, p-chloro-beta-methylphenethylamine and p-methoxy-beta-methylphenethylamine display distinct inhibitory and substrate activities upon MAO-B binding. Density Functional ...