Now showing items 1-10 of 10

    • Lühr, Susan; Vilches Herrera, Marcelo; Fierro, Angélica; Ramsay, Rona R.; Edmondson, Dale E.; Reyes Parada, Miguel; Cassels Niven, Bruce; Iturriaga-Vásquez, Patricio (2010)
      2-Arylthiomorpholine and 2-arylthiomorpholin-5-one derivatives, designed as rigid and/or non-basic phenylethylamine analogues, were evaluated as rat and human monoamine oxidase inhibitors. Molecular docking provided insight ...
    • Sotomayor Zárate, Ramón; Quiroz, Gabriel; Araya, Katherine A.; Abarca, Jorge; Ibáñez, María R.; Montecinos, Alejandro; Guajardo, Carlos; Núñez, Gabriel; Fierro, Angélica; Moya, Pablo R.; Iturriaga-Vásquez, Patricio; Gómez-Molina, Cristóbal; Gysling, Katia; Reyes Parada, Miguel (2012)
      4-Methylthioamphetamine (MTA) is a phenylisopropylamine derivative whose use has been associated with severe intoxications. MTA is usually regarded as a selective serotonin-releasing agent. Nevertheless, previous data have ...
    • Torres, María José; Fierro, Angélica; Pessoa Mahana, Carlos David; Romero Parra, Javier; Cabrera Vallejos, Gonzalo; Faúndez, Mario (Elsevier, 2017)
      Leukotriene A(4) hydrolase is a soluble enzyme with epoxide hydrolase and aminopeptidase activities catalysing the conversion of leukotriene A(4) to leukotriene B-4 and the hydrolysis of the peptide proline-glycine-proline. ...
    • Hugo, Estefanía A.; Cassels Niven, Bruce; Fierro, Angélica (Springer Verlag, 2017)
      © 2017, Springer-Verlag Berlin Heidelberg. The activation mechanism of dopamine receptors is unknown. The amino acids S5.42, S5.43, and S5.46 located in helix 5 appear to be crucial, but their specific roles in receptor ...
    • Osorio Olivares, Mauricio; Rezende, Marcos Caroli; Sepúlveda Boza, Silvia; Cassels Niven, Bruce; Fierro, Angélica (2004)
      Twenty-nine arylisopropylamines, substituted at the β-position of their side chain by an oxo, hydroxy, or methoxy group, were evaluated in vitro as MAO-A and MAO-B inhibitors. The oxo derivatives ('cathinones') were in ...
    • López Villa, Jhon; García-Colunga, Jesús; Pérez, Edwin; Fierro, Angélica (Frontiers Media, 2018-07-10)
      The alpha 7 nicotinic acetylcholine receptor (nAChR) is expressed in neuronal and non-neuronal cells and is involved in several physiopathological processes, and is thus an important drug target. We have designed and ...
    • López, Jhon J.; García-Colunga, Jesús; Pérez, Edwin G.; Fierro, Angélica (Frontiers Media S.A., 2018)
      © 2018 López, García-Colunga, Pérez and Fierro. The α7 nicotinic acetylcholine receptor (nAChR) is expressed in neuronal and non-neuronal cells and is involved in several physiopathological processes, and is thus an important ...
    • Gallardo Godoy, Alejandra; Fierro, Angélica; McLean, Thomas; Castillo, Mariano; Cassels Niven, Bruce; Reyes Parada, Miguel; Nichols, David (2005)
      A series of phenethylamine derivatives with various ring substituents and with or without N-methyl and/or C-alpha methyl or ethyl groups was synthesized and assayed for their ability reversibly to inhibit monoamine oxidase ...
    • Fierro, Angélica; Edmondson, Dale E.; Celis Barros, Cristian; Rebolledo Fuentes, Marco; Zapata Torres, Gerald (Public Library Science, 2016)
      Despite their structural and chemical commonalities, p-chloro-beta-methylphenethylamine and p-methoxy-beta-methylphenethylamine display distinct inhibitory and substrate activities upon MAO-B binding. Density Functional ...
    • Fierro, Angélica; Edmondson, Dale E.; Celis-Barros, Cristian; Rebolledo-Fuentes, Marco; Zapata-Torres, Gerald (Public Library of Science, 2016)
      © 2016 Fierro et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original ...