Browsing by Author "0c0e4ca1-19b2-4958-9555-3de40bbb0a5b"
Now showing items 1-18 of 18
-
(Lippincott Williams and Wilkins, 2002)We have established two immortalized cell lines from dorsal root ganglia of normal (G4b) and trisomy 16 mice (GTI), a model for Down syndrome. By immunohistochemistry, both cell lines exhibit neuronal traits and lack glial ...
-
(2012)Human Down syndrome (DS) is determined by the trisomy of autosome 21 and is expressed by multiple abnormalities, being mental retardation the most striking feature. The condition results in altered electrical membrane ...
-
(2007)Four decades after L-dopa introduction to PD therapy, the cause of Parkinson's disease (PD) remains unknown despite the intensive research and the discovery of a number of gene mutations and delections in the pathogenesis ...
-
(2011)Aminochrome, the precursor of neuromelanin, has been proposed to be involved in the neurodegeneration neuromelanincontaining dopaminergic neurons in Parkinson's disease. We aimed to study the mechanism of aminochrome-dependent ...
-
(2007)Various studies have focused in the relative contribution of different voltage-activated Ca2+ channels (VACC) to total transmitter release. However, how Ca2+ entry through a given VACC subtype defines the pattern of ...
-
(1993)A cell line (RCVC) in permanent culture was developed from adult rat ventricular cells; transformation was attained by incubation with conditioned media from UCHTI, a rat thyroid cell line. Immortalized ventricular cells ...
-
(Academic Press Inc., 2002)We have established hippocampal cell lines from normal and trisomy 16 fetal mice, a model of human trisomy 21. Both cell lines, named H1b (derived from a normal animal) and HTk (trisomic) possess neuronal markers by ...
-
(Public Library of Science, 2019)Mesenchymal stem cells (MSCs) can trans/differentiate to neural precursors and/or mature neurons and promote neuroprotection and neurogenesis. The above could greatly benefit neurodegenerative disorders as well as in the ...
-
(2014)Dynamin-2 is a pleiotropic GTPase whose best-known function is related to membrane scission during vesicle budding from the plasma or Golgi membranes. In the nervous system, dynamin-2 participates in synaptic vesicle ...
-
(2007)The CNh and CTb cell lines are derived from the cerebral cortex of normal and trisomy 16 mice, an animal model of human trisomy 21, Down syndrome (DS), and represent in vitro models to study cellular events associated with ...
-
(Springer New York LLC, 2010)
-
(2002)We report the establishment of continuously growing cell lines from spinal cords of normal and trisomy 16 fetal mice. We show that both cell lines, named M4b (derived from a normal animal) and MTh (trisomic) possess ...
-
(2011)The in vitro effect of the resinous exudate of Heliotropium filifolium, of the 3 H-spiro[1-benzofuran-2,1'-cyclohexane] derivative called filifolinol 1, isolated from the resin and the semi-synthetic compounds filifolinone ...
-
Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society (S. Karger AG, 2019)© 2018 S. Karger AG, Basel.In the last decade, a number of important research advances in different fields have allowed Down syndrome (DS) research to flourish, creating a time of both unparalleled opportunity and considerable ...
-
(2012)Parkinson's disease is a debilitating progressive neurodegenerative disorder that results from the loss of or damage to dopaminergic cells containing neuromelanin in the substantia nigra (SN). The underlying neurodegenerative ...
-
(Frontiers Media, 2018-07-06)In humans, Down Syndrome (DS) is a condition caused by partial or full trisomy of chromosome 21. Genes present in the DS critical region can result in excess gene dosage, which at least partially can account for DS phenotype. ...
-
(Elsevier, 2012)Neurodegenerative disorders constitute a growing concern worldwide. Their incidence has increased steadily, in particular among the elderly, a high-risk population that is becoming an important segment of society. ...
