Now showing items 1-20 of 21

    • Ocaranza, Maria Paz; Lavandero González, Sergio; Jalil Milad, Jorge; Moya, Jaqueline; Pinto, Melissa; Novoa, Ulises; Apablaza, Felipe; González, Leticia; Hernández, Carol; Varas, Manuel; López, René; Godoy, Iván; Verdejo, Hugo; Chiong Lay, Mario (Lippincott Williams and Wilkins, 2010)
      Background: Angiotensin-(1-9) is present in human and rat plasma and its circulating levels increased early after myocardial infarction or in animals treated with angiotensin-converting enzyme inhibitor. However, the ...
    • Ferreccio, Catterina; Huidobro, Andrea; Cortés, Sandra; Bambs, Claudia; Toro, Pablo; Van De Wyngard, Vanessa; Acevedo, Johanna; Paredes, Fabio; Venegas, Pía; Verdejo, Hugo; Oyarzún González, Ximena; Cook, Paz; Castro, Pablo F.; Foerster, Claudia; Vargas, Claudio; Koshiol, Jill; Araya, Juan Carlos; Cruz, Francisco; Corvalán, Alejandro H.; Quest, Andrew F.; Kogan, Marcelo J.; Lavandero González, Sergio (Oxford University Press, 2020)
    • Verdejo, Hugo; Díaz, Felipe; Castro, Pablo; Rossel Mariangel, Víctor; Concepción, Roberto; Sepúlveda, Luis (Sociedad Chilena de Cardiología, 2014)
      Antecedentes: Uno de los principales predictores de eventos adversos en pacientes con insuficiencia cardíaca (IC) es el deterioro de función renal luego de una hospitalización. Estudios recientes han cuestionado la ...
    • Díaz-Toro, Felipe; Nazzal Nazal, Carolina; Verdejo, Hugo; Rossel, Víctor; Castro, Pablo; Larrea, Ricardo; Concepción, Roberto; Sepúlveda, Luis; Sepúlveda, Luis (Sociedad Medica de Santiago, 2017)
      © 2017 Rev Med Chile. All right reserved. Background: Frailty is a geriatric syndrome characterized by a progressive impairment in the subjects’ ability to respond to environmental stress. Frailty is more commonly found ...
    • Rossel, Víctor; Díaz-Toro, Felipe; Verdejo, Hugo; Concepción, Roberto; Sepúlveda, Luis; Castro, Pablo; Vukasovic, José Luis; Bernales, Angie; Bernales, Angie (Sociedad Medica de Santiago, 2017)
      © 2017, Sociedad Medica de Santiago. All rights reserved. Background: Galectin-3 (Gal-3) is a mediator of myocardial fibrosis involved in cardiac remodeling and a potential new prognosis marker in heart failure (HF). Aim: ...
    • Rossel Mariangel, Víctor Alejandro; Díaz Toro, Felipe; Verdejo, Hugo; Concepcion, Roberto; Sepúlveda Jaqui, Luis; Castro, Pablo; Vukasovic, José Luis; Bernales, Angie (Sociedad Médica Santiago, 2017)
      Galectin-3 (Gal-3) is a mediator of myocardial fibrosis involved in cardiac remodeling and a potential new prognosis marker in heart failure (HF). Aim: To measure Gal-3 at the moment of discharge in patients hospitalized ...
    • Marambio, Paola; Toro, Barbra; Sanhueza, Carlos; Troncoso, Rodrigo; Parra, Valentina; Verdejo, Hugo; García Nannig, Lorena; Quiroga, Clara; Munafo, Daniela; Díaz Elizondo, Jessica; Bravo Sagua, Roberto; González Burgos, María Julieta; Díaz Araya, Guillermo; Pedrozo Cibils, Zully; Chiong Lay, Mario; Co (2010)
      Aggresomes are dynamic structures formed when the ubiquitin-proteasome system is overwhelmed with aggregation-prone proteins. In this process, small protein aggregates are actively transported towards the microtubule-organizing ...
    • Castro, Pablo; Gabrielli, Luigi; Verdejo, Hugo; Greig, Douglas; Mellado, Rosemarie; Concepción, Roberto; Sepulveda, Luis; Vukasovic, José Luis; García Nannig, Lorena; Pizarro, Marcela; Pivet, Deisy; Carrillo, Constanza; Tapia, Fabiola; Navarro, Mario; Troncoso, Rodrigo; Baraon (2010)
      It is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the ...
    • García Nannig, Lorena; Verdejo, Hugo; Kuzmicic, Jovan; Zalaquett Sepúlveda, Ricardo; Gonzalez, Sergio; Lavandero González, Sergio; Corbalán, Ramón (Mosby Inc., 2012)
      Objectives: Postoperative atrial fibrillation (POAF) is a common complication after on-pump heart surgery. Several histologic abnormalities, such as interstitial fibrosis and vacuolization, have been described in atrial ...
    • Castro, Pablo; Verdejo, Hugo; Altamirano, Rodrigo; Downey, Patricio; Vukasovic, José Luis; Sepúlveda Jaqui, Luis; Lanas, Fernando; Bilbao, Paola; Pacheco, Ricardo; Rossel, Víctor (Sociedad Médica de Santiago, 2013)
      Background: Acute deterioration of kidney function among patients admitted to the hospital for cardiac failure is associated with an increased mortality. Aim: To investigate the association between deterioration of kidney ...
    • Díaz Toro, Felipe; Nazzal Nazal, Carolina; Verdejo, Hugo (Sociedad Médica Santiago, 2017)
      Background: Gender may influence the incidence, severity and hospital mortality due to heart failure (HF). Aim: To evaluate the influence of sex on the proportion of patients hospitalized due to heart failure, its incidence ...
    • Greig, Douglas; Castro, Pablo; Gabrielli, Luigi; Miranda, Rodrigo; Verdejo, Hugo; Alcaíno Gálvez, Hernán Alejandro; Bustos, Carlos; Chiong Lay, Mario; Godoy, Iván; Mellado, Rosemarie; García Nannig, Lorena; Salas, Daniela; Vivar, Raúl; Vukasovic, José Luis; Concepción, Roberto; Díaz Araya, Guillermo (2008)
      Background: In chronic heart failure (CHF), endothelial dysfunction (ED) is a consequence of an imbalance of vascular tone regulating substances. The relationship between ED and inflammation has not been fully investigated. ...
    • Verdejo, Hugo; Campo, Andrea del; Troncoso, Rodrigo; Gutiérrez, Tomás; Toro, Barbra; Quiroga, Clara; Pedrozo Cibils, Zully; Muñoz, Juan; García Nannig, Lorena; Castro, Pablo; Lavandero González, Sergio (2012)
      The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
    • Kuzmicic, Jovan; Del Campo, Andrea; López Crisosto, Camila; Morales, Pablo E.; Pennanen, Christian; Bravo Sagua, Roberto; Hechenleitner, Jonathan; Zepeda, Ramiro; Castro, Pablo F.; Verdejo, Hugo; Parra, Valentina; Chiong Lay, Mario; Lavandero González, Sergio (2011)
      Mitochondria are dynamic organelles able to vary their morphology between elongated interconnected mitochondrial networks and fragmented disconnected arrays, through events of mitochondrial fusion and fission, respectively. ...
    • Winter, José Luis; Castro, Pablo; Meneses, Luis; Chalhub, Mónica; Verdejo, Hugo; Greig, Douglas; Gabrielli, Luigi; Chiong Lay, Mario; Concepción, Roberto; Mellado, Rosemarie; Hernández, Claudia; Uribe, Sergio; Lavandero González, Sergio (2010)
      Background: Heart failure (HF) is characterized, among other features, by the development of alterations in myocardial energy metabolism, involving a decrease in glucose utilization and increased free fatty acid uptake by ...
    • Miranda H, Rodrigo; Castro G, Pablo; Verdejo, Hugo; Chiong Lay, Mario; Díaz Araya, Guillermo; Mellado, Rosemarie; Rojas, Diego; Concepción, Roberto; Lavandero González, Sergio (2007)
      Despite advances in treatment, chronic heart failure still is associated with a poor prognosis and remains a leading cause of cardiovascular death. Cumulating evidence suggests that imbalances in redox state lead to a ...
    • Castro, Pablo; Winter, José Luis; Verdejo, Hugo; Orellana, Pilar; Quintana, Juan Carlos; Greig, Douglas; Enríquez, Andrés; Sepúlveda, Luis; Concepción, Roberto; Sepúlveda, Pablo; Rossel, Victor; Chiong Lay, Mario; García Nannig, Lorena; Lavandero González, Sergio (2012)
      Background: Ventricular dyssynchrony is a common finding in patients with heart failure (HF), especially in the presence of conduction delays. The loss of ventricular synchrony leads to progressive impairment of contractile ...
    • Herrera, Sebastián; Gabrielli, Luigi A.; Paredes, Alejandro; Saavedra, Rodrigo; Paz Ocaranza, María; Fuentes Sepúlveda, Pablo Ignacio; Donoso, Hernán; López, Leonel; Verdejo, Hugo; Baraona, Fernando (Soc. Médica Santiago, 2016)
      Background: Pulmonary arterial hypertension (PAH) is a rare and progressive disease. Long-term survival remains poor despite of advances in specific vasodilator therapy. Aim: To describe the survival rate in a cohort of ...
    • Gabrielli, Luigi; Castro, Pablo F.; Godoy, Ivan; Mellado, Rosemarie; Bourge, Robert C.; Alcaíno Gálvez, Hernán Alejandro; Chiong Lay, Mario; Greig, Douglas; Verdejo, Hugo; Navarro, Mario; Lopez, Rafael; Toro, Barbra; Quiroga, Clara; Díaz Araya, Guillermo; Lavandero González, Sergio; Garcia, Lo (2011)
      Background: Systemic endothelial dysfunction and increased oxidative stress have been observed in pulmonary arterial hypertension (PAH). We evaluate whether oxidative stress and endothelial dysfunction are associated with ...
    • Verdejo, Hugo; Roldán, Juan; García Nannig, Lorena; Del Campo, Andrea; Becerra, Elia; Chiong Lay, Mario; Mellado, Rosemarie; Garcia, Amalia; Zalaquett Sepúlveda, Ricardo; Braun, Sandra; Garayar, Bernardita; Gonzalez, Sergio; Lavandero González, Sergio; Corbalán, Ramón (2011)
      Background: Post-operative atrial fibrillation occurs in 30% of patients after on-pump heart surgery and is associated to elevated inflammatory markers. We have evaluated if the systemic biomarkers of inflammation and ...