Browsing by Author "0d8bec3c-51a3-4513-8687-38cca863b0af"
Now showing items 1-13 of 13
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McDonald, Tanya S.; Carrasco Pozo, Catalina; Hodson, Mark P.; Borges, Karin (Soc Neuroscience, 2017)Temporal lobe epilepsy is a common form of adult epilepsy and shows high resistance to treatment. Increasing evidence has suggested that metabolic dysfunction contributes to the development of seizures, with previous studies ...
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Wong, Ximena; Carrasco Pozo, Catalina; Escobar, Elizabeth; Navarrete Wallace, Paola; Blachier, Francois; Andriamihaja, Mireille; Lang, Annaig; Tome, Daniel; Cires, María José; Pastene, Edgar; Gotteland, Martin (Amer Chemical Society, 2016)The protective effect of proanthocyanidin-containing polyphenol extracts from apples, avocados, cranberries, grapes, or proanthocyanidin microbial metabolites was evaluated in colonic epithelial cells exposed to p-cresol, ...
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Castillo, Rodrigo; Ibacache, Mauricio; Cortínez, Ignacio; Carrasco Pozo, Catalina; Farías, Jorge G.; Carrasco, Rodrigo A.; Vargas Errázuriz, Patricio; Ramos Soto, Daniel; Benavente Aránguiz, Rafael; Henríquez Torres, Daniela; Méndez, Aníbal (Frontiers Media, 2020)Dexmedetomidine (DEX) is a highly selective alpha 2-adrenergic agonist with sedative and analgesic properties, with minimal respiratory effects. It is used as a sedative in the intensive care unit and the operating room. ...
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Morales, Pamela; Fujio, Sayaka; Navarrete Wallace, Paola; Ugalde, Juan; Magne, Fabien; Carrasco Pozo, Catalina; Tralma, Karina; Quezada, María Paz; Hurtado Heim, Carmen; Natalia Covarrubias, Natalia; Brignardello, Jerusa; Henríquez, Daniela; Gotteland, Martín (Nature, 2016)OBJECTIVES: High-fat diets alter gut microbiota and barrier function, inducing metabolic endotoxemia and low-grade inflammation. Whether these effects are due to the high dietary lipid content or to the concomitant decrease ...
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Aguilar, Miguel; González Candia, Alejandro; Rodríguez Borges, Jorge; Carrasco Pozo, Catalina; Canas, Daniel; García Herrera, Claudio; Herrera Videla, Emilio; Castillo Peñaloza, Rodrigo (MDPI, 2018)More than 140 million people live and works (in a chronic or intermittent form) above 2500 m worldwide and 35 million live in the Andean Mountains. Furthermore, in Chile, it is estimated that 55,000 persons work in high ...
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Wong, Ximena; Madrid Silva, Ana; Tralma, Karina; Castillo, Romina; Carrasco Pozo, Catalina; Navarrete Wallace, Paola; Beltrán Muñoz, Caroll; Pastene, Edgar; Gotteland, Martin (Elsevier Science, 2016-10)The intestinal absorption of bacterial lipopolysaccharide (LPS) and dietary fat has been implicated in the development of metabolic endotoxemia. This study first compared the ability of polyphenol extracts from grape, ...
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Andriamihaja, Mireille; Lan, Annaig; Beaumont, Martin; Grauso, Marta; Gotteland, Martin; Pastene, Edgar; Cires, María José; Carrasco Pozo, Catalina; Tome, Daniel; Blachier, Francois (Springer, 2018-06)Hydrogen sulfide (H2S), a metabolic end product synthesized by the microbiota from l-cysteine, has been shown to act at low micromolar concentration as a mineral oxidative substrate in colonocytes while acting as an inhibitor ...
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Fuentes, Jocelyn; Atala, Elías; Pastene, Edgar; Carrasco Pozo, Catalina; Speisky Cosoy, Hernán (American Chemical Society, 2017)Quercetin oxidation is generally believed to ultimately result in the loss of its antioxidant properties. To test this assertion, quercetin oxidation was induced, and after each of its major metabolites was identified and ...
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Castillo, Rodrigo L.; Herrera Videla, Emilio; González Candia, Alejandro; Reyes Farías, Marjorie; Jara, Nicole de la; Peña, Juan Pedro; Carrasco Pozo, Catalina (Hindawi Ltd, 2018)Alterations in cardiac energy metabolism play a key role in the pathogenesis of diabetic cardiomyopathy. Hypercholesterolemia associated with bioenergetic impairment and oxidative stress has not been well characterized in ...
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Carrasco Pozo, Catalina; Tan, Kah Ni; Reyes Farías, Marjorie; De la Jara, Nicole; Ngo, Shyuan Thieu; García Díaz, Diego; Llanos Vidal, Paola; Cires, María José; Borges, Karin (Elsevier, 2016)Studying rats fed high cholesterol diet and a pancreatic beta-cell line (Min6), we aimed to determine the mechanisms by which quercetin protects against cholesterol-induced pancreatic beta-cell dysfunction and impairments ...
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Cires, María José; Wong, Ximena; Carrasco Pozo, Catalina; Gotteland, Martín (Frontiers media SA, 2017)Proanthocyanidins (PACs) are polymers of flavan-3-ols abundant in many vegetable foods and beverages widely consumed in the human diet. There is increasing evidence supporting the beneficial impact of dietary PACs in the ...
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Catalán Díaz, Mabel; Ferreira, Jorge; Carrasco Pozo, Catalina (MDPI, 2020)Meat diet plays a pivotal role in colorectal cancer (CRC). Hemin, a metabolite of myoglobin, produced after meat intake, has been involved in CRC initiation. The compound, 3,4-dihydroxyphenylacetic acid (3,4HPAA) is a ...
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Tan, Kah Ni; Simmons, David; Carrasco Pozo, Catalina; Borges, Karin (Wiley, 2018)Triheptanoin, the triglyceride of heptanoate, is anaplerotic (refills deficient tricarboxylic acid cycle intermediates) via the propionyl-CoA carboxylase pathway. It has been shown to be neuroprotective and anticonvulsant ...