Browsing by Author "0da79ed6-6dc9-4c2c-9e2a-4ed7f922f19a"

Now showing items 1-15 of 15

    • Antenatal melatonin modulates an enhanced antioxidant/pro-oxidant ratio in pulmonary hypertensive newborn sheep 
      Gonzalez-Candia, Alejandro; Veliz, Marcelino; Carrasco-Pozo, Catalina; Castillo, Rodrigo L.; Cárdenas, J. Cesar; Ebensperger, Germán; Reyes, Roberto V.; Llanos, Aníbal J.; Herrera, Emilio A. (Elsevier B.V., 2019)
      Chronic hypobaric hypoxia during fetal and neonatal life induces neonatal pulmonary hypertension. Hypoxia and oxidative stress are driving this condition, which implies an increase generation of reactive oxygen species ...
    • Evolving in thin air-Lessons from the llama fetus in the altiplano 
      Llanos Mansilla, Jorge; Riquelme, Raquel A.; Herrera, Emilio A.; Ebensperger Darrouy, Germán; Krause, Bernardo; Reyes, Roberto V.; Sanhueza, Emilia M.; Pulgar, Víctor M.; Behn, Claus; Cabello, Gertrudis; Parer, Julian T.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A. (2007)
      Compared with lowland species, fetal life for mammalian species whose mothers live in high altitude is demanding. For instance, fetal llamas have to cope with the low fetal arterial PO2 of all species, but also the likely ...
    • Evolving in thin air—Lessons from the llama fetus in the altiplano 
      Llanos Mansilla, Jorge; Riquelme González, Raquel; Herrera Videla, Emilio; Ebensperger Darrouy, Germán; Krause, Bernardo; Reyes, Roberto V.; Sanhueza Reinoso, Emilia; Pulgar, Víctor M.; Behn Thiele, Claus; Cabello, Gertrudis; Parer, Julian T.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A. (ELSEVIER, 2007)
      Compared with lowland species, fetal life for mammalian species whose mothers live in high altitude is demanding. For instance, fetal llamas have to cope with the lowfetal arterial PO2 of all species, but also the likely ...
    • Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension ... 
      Herrera, Emilio A.; Riquelme, Raquel A.; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Ulloa, César E.; Cabello, Gertrudis; Krause, Bernardo J.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (2010)
      We determined whether postnatal pulmonary hypertension induced by 70% of pregnancy at high altitude (HA) persists once the offspring return to sea level and investigated pulmonary vascular mechanisms operating under these ...
    • Potential adverse effects of antenatal melatonin as a treatment for intrauterine growth restriction: findings ... 
      González Candia, Alejandro; Véliz, Marcelino; Araya, Claudio; Quezada, Sebastián; Ebensperger Darrouy, Germán; Serón Ferré, María; Reyes, Roberto V.; Llanos Mansilla, Jorge; Herrera Videla, Emilio (Mosby-Elsevier, 2016)
      BACKGROUND: Intrauterine growth restriction is a condition in which the fetus has a birthweight and/or length <10th percentile for the gestational age. Intrauterine growth restriction can be associated with various causes, ...
    • Revisiting the role of TRP, orai, and ASIC channels in the pulmonary arterial response to hypoxia 
      Reyes, Roberto V.; Castillo Galán, Sebastián; Hernández, Ismael; Herrera, Emilio A.; Ebensperger Darrouy, Germán; Llanos Mansilla, Jorge (Frontiers Media S.A., 2018)
      © 2018 Reyes, Castillo-Galán, Hernandez, Herrera, Ebensperger and Llanos. The pulmonary arteries are exquisitely responsive to oxygen changes. They rapidly and proportionally contract as arterial PO2 decrease, and they ...
    • Role of the RhoA/ROCK pathway in high-altitude associated neonatal pulmonary hypertension in lambs 
      López, Nandy; Ebensperger Darrouy, Germán; Herrera Videla, Emilio; Reyes, Roberto V.; Calaf, Gloria; Cabello, Gertrudis; Moraga, Fernando; Benaldo, Felipe A.; Díaz, Marcela; Parer, Julian T.; Llanos Mansilla, Jorge (Amer Physiological Soc, 2016)
      Exposure to high-altitude chronic hypoxia during pregnancy may cause pulmonary hypertension in neonates, as a result of vasoconstriction and vascular remodeling. We hypothesized that susceptibility to pulmonary hypertension, ...
    • Role of the α-adrenergic system in femoral vascular reactivity in neonatal llamas and sheep: A comparative ... 
      Moraga, Fernando A.; Reyes, Roberto V.; Herrera, Emilio A.; Riquelme, Raquel A.; Ebensperger Darrouy, Germán; Pulgar, Víctor M.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (2011)
      Using an integrative approach at the whole animal, isolated vessels, and molecular levels, we tested the hypothesis that the llama, a species that undergoes pregnancy under the influence of the chronic hypoxia of high ...
    • Stim-activated TRPC-ORAI channels in pulmonary hypertension induced by chronic intermittent hypoxia 
      Castillo Galán, Sebastián; Arenas, Germán A.; Reyes, Roberto V.; Krause, Bernardo J.; Iturriaga, Rodrigo (SAGE, 2020)
      Obstructive sleep apnea (OSA), a breathing disorder featured by chronic intermittent hypoxia (CIH) is associated with pulmonary hypertension (PH). Rodents exposed to CIH develop pulmonary vascular remodeling and PH, but ...
    • Study of the Effect of Treatment With Atrial Natriuretic Peptide (ANP) and Cinaciguat in Chronic Hypoxic ... 
      Navarrete, Álvaro; Chen, Zhuoming; Aranda, Pedro; Poblete, Daniel; Utrera, Andrés; García Herrera, Claudio; González Candia, Alejandro; Beñaldo, Felipe A.; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Herrera Videla, Emilio; Llanos, Aníbal J. (Frontiers Media, 2020)
      In this study, we assessed the effects of Atrial Natriuretic Peptide (ANP) and Cinaciguat, as experimental medicines to treat neonatal lambs exposed to chronic hypoxic conditions. To compare the different treatments, the ...
    • The heme oxygenase-carbon monoxide system in the regulation of cardiorespiratory function at high altitude 
      Llanos Mansilla, Jorge; Ebensperger Darrouy, Germán; Herrera, Emilio A.; Reyes, Roberto V.; Cabello, Gertrudis; Díaz Díaz, Marcela Cecilia; Giussani, Dino A.; Parer, Julian T. (2012)
      Pulmonary arterial hypertension is one of the most serious pathologies that can affect the 140 million people living at altitudes over 2500. m. The primary emphasis of this review is pulmonary artery hypertension in mammals ...
    • The newborn sheep translational model for pulmonary arterial hypertension of the neonate at high altitude 
      González Candia, Alejandro; Candia Henríquez, Alejandro; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Llanos, Anibal J.; Herrera Videla, Emilio (Cambridge University Press, 2020)
      Chronic hypoxia during gestation induces greater occurrence of perinatal complications such as intrauterine growth restriction, fetal hypoxia, newborn asphyxia, and respiratory distress, among others. This condition may ...
    • The placental pursuit for an adequate oxidant balance between the mother and the fetus 
      Herrera, Emilio A.; Krause, Bernardo; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Casanello, Paola; Parra Cordero, Mauro; Llanos Mansilla, Jorge (Frontiers Research Foundation, 2014)
      The placenta is the exchange organ that regulates metabolic processes between the mother and her developing fetus. The adequate function of this organ is clearly vital for a physiologic gestational process and a healthy ...
    • The role of nitric oxide in the cardiopulmonary response to hypoxia in highland and lowland newborn llamas 
      Reyes, Roberto V.; Díaz Díaz, Marcela Cecilia; Ebensperger Darrouy, Germán; Herrera, Emilio A.; Quezada, Sebastián A.; Hernández, Ismael; Sanhueza, Emilia M.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (Blackwell Publishing Ltd, 2018)
      © 2018 The Physiological Society. Key points: Perinatal hypoxia causes pulmonary hypertension in neonates, including humans. However, in species adapted to hypoxia, such as the llama, there is protection against pulmonary ...
    • The role of nitric oxide signaling in pulmonary circulation of high- and low-altitude newborn sheep under ... 
      Herrera, Emilio A.; Ebensperger, Germán; Hernández, Ismael; Sanhueza, Emilia M.; Llanos, Aníbal J.; Reyes, Roberto V. (Academic Press Inc., 2019)
      Nitric oxide (NO) is the main vasodilator agent that drives the rapid decrease of pulmonary vascular resistance for the respiratory onset during the fetal to neonatal transition. Nevertheless, the enhanced NO generation ...