Browsing by Author "0fa72f7b-4074-4d49-9e0e-4db09ba63607"

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    • BRDT is an essential epigenetic regulator for proper chromatin organization, silencing of sex chromosomes ... 
      Manterola Zúñiga, Marcia; Brown, Taylor M.; Young Oh, Min; Garyn, Corey; González, Bryan J.; Wolgemuth, Debra J. (Public Library Science, 2018)
      The double bromodomain and extra-terminal domain (BET) proteins are critical epigenetic readers that bind to acetylated histones in chromatin and regulate transcriptional activity and modulate changes in chromatin structure ...
    • Ski Is required for tri-methylation of H3K9 in major satellite and for repression of pericentromeric genes: ... 
      Cappelli, Claudio; Sepúlveda, Hugo; Rivas Vera, Solange; Pola Véliz, Víctor; Urzúa Tobar, Ulises; Donoso Luna, Gerardo; Sagredo Campos, Eduardo; Carrero Zapata, David; Casanova Ortiz, Emmanuel; Sagredo Campos, Alfredo; González Vergara, Marisel; Manterola Zúñiga, Marcia; Nardocci, Gino; Armisén Yañez, Ricardo; Montecino, Martín; Marcelain Cubillos, Katherine (Elsevier, 2020)
      Several mechanisms directing a rapid transcriptional reactivation of genes immediately after mitosis have been described. However, little is known about the maintenance of repressive signals during mitosis. In this work, ...
    • Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent ... 
      Jury, Nur; Abarzúa, Sebastián; Díaz, Iván; Guerra, Miguel V.; Ampuero, Estibaliz; Cubillos, Paula; Martínez, Pablo; Herrera Soto, Andrea; Arredondo, Cristian; Rojas, Fabiola; Manterola Zúñiga, Marcia; Rojas, Adriana; Montecino, Martín; Varela Nallar, Lorena; van Zundert, Brigitte (BMC, 2020)
      Background Hexanucleotide repeat expansions of the G(4)C(2) motif in a non-coding region of the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Tissues ...