Browsing by Author "12a10c07-68b4-4023-b20b-7625f3457631"

Now showing items 1-3 of 3

    • Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease 
      Lebeaupin, Cynthia; Vallée, Deborah; Hazari, Younis; Hetz Flores, Claudio; Chevet, Eric; Bailly-Maitre, Béatrice (Elsevier B.V., 2018)
      © 2018 The global epidemic of obesity has been accompanied by a rising burden of non-alcoholic fatty liver disease (NAFLD), with manifestations ranging from simple steatosis to non-alcoholic steatohepatitis, potentially ...
    • Genotoxic stress triggers the activation of IRE1 alpha-dependent RNA decay to modulate the DNA damage response 
      Dufey, Estefanie; Bravo San Pedro, José; Eggers Aracena, Cristián; González Quiroz, Matías; Urra Zúñiga, Hery; Sagredo Campos, Alfredo; Sepúlveda Alvarado, Denisse; Pihán Najle, Philippe; Carreras Sureda, Armando; Hazari, Younis; Sagredo, Eduardo A.; Gutiérrez, Daniela; Valls, Cristian; Papaioannou, Alexandra; Acosta Alvear, Diego; Campos, Gisela; Domingos, Pedro M.; Pedeux, Rémy; Chevet, Eric; Álvarez, Alejandra R.; Godoy, Patricio; Walter, Peter; Glavic Maurer, Álvaro; Kroemer, Guido; Hetz Flores, Claudio (Nature, 2020)
      The molecular connections between homeostatic systems that maintain both genome integrity and proteostasis are poorly understood. Here we identify the selective activation of the unfolded protein response transducer IRE1 ...
    • Serpina1 hepatocyte-specific promoter polymorphism associate with chronic obstructive pulmonary disease in ... 
      Bashir, Arif; Hazari, Younis; Bashir, Samirul; Hilal, Nazia; Banday, Mariam; Iqbal, Mir; Jan, Tariq; Farooq, Syed; Shah, Naveed; Fazili, Khalid (Springer, 2018-08)
      Different mutations in coding and non-coding sequences of the SERPINA1 gene have been implicated in the pathogenesis of COPD. However, - 10T/C mutation in the hepatocyte-directed promoter region has not been associated ...