Browsing by Author "1871d92f-fa0d-4e1f-86e1-ccab63bb8d96"

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    • 11β-hydroxysteroid dehydrogenase type-2 and type-1 (11β-HSD2 and 11β-HSD1) and 5β-reductase activities in ... 
      Campino, Carmen; Carvajal, Cristian A.; Cornejo, Javiera; San Martín Núñez, Betty; Olivieri, Oliviero; Guidi, Giancesare; Faccini, Giovanni; Pasini, Francesco; Sateler, Javiera; Baudrand, Rene; Mosso, Lorena; Owen, Gareth I.; Kalergis, Alexis M.; Padilla, Oslando; Fardella, Patricia (2010)
      Cortisol availability is modulated by several enzymes: 11β-HSD2, which transforms cortisol (F) to cortisone (E) and 11β-HSD1 which predominantly converts inactive E to active F. Additionally, the A-ring reductases (5α- and ...
    • Aldosterone, plasma renin activity, and aldosterone/renin ratio in a normotensive healthy pediatric population 
      Martínez Aguayo, Alejandro; Aglony, Marlene; Campino, Carmen; Garcia, Hernan; Bancalari, Rodrigo; Bolte, Lillian; Avalos, Carolina; Loureiro, Carolina; Carvajal, Cristian A.; Avila, Alejandra; Perez, Viviana; Inostroza, Andrea; Fardella, Carlos E. (2010)
      Primary aldosteronism is an important cause of secondary hypertension and is suspected in adults with an aldosterone/renin ratio ≥25. The normal aldosterone/renin ratio is unknown in children. The aim was to establish serum ...
    • Frequency of familial hyperaldosteronism type 1 in a hypertensive pediatric population: Clinical and ... 
      Aglony, Marlene; Martínez-Aguayo, Alejandro; Carvajal, Cristian A.; Campino, Carmen; García, Hernán; Bancalari, Rodrigo; Bolte, Lillian; Avalos, Carolina; Loureiro, Carolina; Trejo, Pamela; Brinkmann, Karin; Giadrosich, Vinka; Mericq, Verónica; Rocha, Ana; Avila, Aleja (Lippincott Williams and Wilkins, 2011)
      Familial hyperaldosteronism type 1 is an autosomal dominant disorder attributed to a chimeric CYP11B1/CYP11B2 gene (CG). Its prevalence and manifestation in the pediatric population has not been established. We aimed to ...
    • Identification of novel 11β-HSD1 inhibitors by combined ligand- and structure-based virtual screening 
      Lagos, Carlos F.; Vecchiola, Andrea; Allende, Fidel; Fuentes, Cristobal A.; Tichauer, Juan E.; Valdivia, Carolina; Solari, Sandra; Campino, Carmen; Tapia-Castillo, Alejandra; Baudrand, Rene; Villarroel, Pia; Cifuentes, Mariana; Owen, Gareth I.; Carvajal, Cristian A. (2014)
      11 beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts cortisone to cortisol in a NADPH dependent manner. Overexpression of 11β-HSD1 in key metabolic tissues is related to the development of type 2 diabetes, ...
    • Increased levels of oxidative stress, subclinical inflammation, and myocardial fibrosis markers in primary ... 
      Stehr, Carlos B.; Mellado, Rosemarie; Ocaranza, Maria P.; Carvajal, Cristian A.; Mosso, Lorena; Becerra, Elia; Solis, Margarita; García Nannig, Lorena; Lavandero González, Sergio; Jalil Milad, Jorge; Fardella, Carlos E. (2010)
      Background: Patients with primary aldosteronism experience greater left ventricular hypertrophy and a higher frequency of cardiovascular events than do essential hypertensive patients with comparable blood pressure levels. ...
    • Increased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, ... 
      Baudrand, Rene; Campino, Carmen; Carvajal, Cristian A.; Olivieri, Oliviero; Guidi, Giancesare; Faccini, Giovanni; Sateler, Javiera; Cornejo, Javiera; San Martín Núñez, Betty; Dominguez, Jose M.; Cerda, Jaime; Mosso, Lorena M.; Owen, Gareth I.; Kalergis, Alexis M.; Fardella, Patricia (2011)
      Metabolic syndrome (MetS) may have increased cortisol (F) production caused by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in liver and adipose tissue and/or by HPA axis dysregulation. F is then mainly metabolized by ...
    • The expression of RAC1 and mineralocorticoid pathway-dependent genes are associated with different responses ... 
      Tapia Castillo, Alejandra; Carvajal, Cristian A.; Campino, Carmen; Hill, Caroline; Allende, Fidel; Vecchiola, Andrea; Carrasco, Carmen; Bancalari, Rodrigo; Valdivia, Carolina; Lagos, Carlos; Martínez Aguayo, Alejandro; Garcia, Hernan; Aglony, Marlene; Baudrand, Rene F (Oxford University Press, 2015)
      © American Journal of Hypertension, Ltd 2014. All rights reserved.Background Rac1 upregulation has been implicated in salt-sensitive hypertension as a modulator of mineralocorticoid receptor (MR) activity. Rac1 could affect ...