Browsing by Author "1872707e-8649-4e54-912e-95c985ca5dc2"

Now showing items 1-15 of 15

    • Basal autophagy protects cardiomyocytes from doxorubicin-induced toxicity 
      Pizarro, Marcela; Troncoso Cotal, Rodrigo; Martínez, Gonzalo J.; Chiong Lay, Mario; Castro, Pablo F.; Lavandero González, Sergio (Elsevier, 2016)
      Doxorubicin (Doxo) is one of the most effective anti-neoplastic agents but its cardiotoxicity has been an important clinical limitation. The major mechanism of Doxo-induced cardiotoxicity is associated to its oxidative ...
    • beta -Hydroxybutyrate increases exercise capacity associated with changes in mitochondrial function in ... 
      Monsalves Álvarez, Matías; Morales Campos, Pablo; Castro Sepúlveda, Mauricio; Sepúlveda Guzmán, Carlos; Rodríguez Silva, Juan Manuel; Chiong Lay, Mario; Eisner, Verónica; Lavandero González, Sergio; Troncoso Cotal, Rodrigo (MDPI, 2020)
      beta-hydroxybutyrate is the main ketone body generated by the liver under starvation. Under these conditions, it can sustain ATP levels by its oxidation in mitochondria. As mitochondria can modify its shape and function ...
    • Cardiovascular autophagy concepts, controversies, and perspectives 
      Lavandero González, Sergio; Troncoso Cotal, Rodrigo; Rotherme, Beverly; Martinet, Wim; Sadoshima, Junichi; Hill, Joseph (Taylor and Francis Inc., 2013)
      Despite recent scientific and technological advances, cardiovascular disease remains the leading cause of morbidity and mortality worldwide. Autophagy, an evolutionarily ancient response to cellular stress, has been ...
    • Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury 
      Zepeda Iriarte, Ramiro; Kuzmicic, Jovan; Parra Ortiz, Valentina; Troncoso Cotal, Rodrigo; Pennanen, Christian; Riquelme, Jaime A.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Sánchez, Gina; Lavandero González, Sergio (Lippincott Williams and Wilkins, 2014)
      Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated by processes of fission and fusion. We hypothesized that the mitochondria fusion protein dynamin-related protein 1 (Drp1) inhibition, ...
    • Gln27→Gluβ2-adrenergic receptor polymorphism in heart failure patients: Differential clinical and oxidative ... 
      Troncoso Cotal, Rodrigo; Moraga, Francisco; Chiong Lay, Mario; Roldán, Juan; Bravo, Roberto; Valenzuela, Rodrigo; Díaz Araya, Guillermo; Del Campo, Andrea; Sanhueza, Carlos; Rodriguez, Andrea; Vukasovic, José Luis; Mellado, Rosemarie; Greig, Douglas; Castro, Pablo F.; Lavandero González, Sergio (2009)
      We investigated the clinical response of chronic heart failure patients with β2-adrenergic receptor Gln27→Glu polymorphism treated for 6 months with carvedilol, a α/β-antagonist with antioxidant properties. The 6-min. walk ...
    • Glucocorticoid resistance in chronic diseases 
      Rodriguez, Juan; Monsalves Álvarez, Matías; Henriquez, Sandra; Llanos Silva, Miguel; Troncoso Cotal, Rodrigo (Elsevier Science, 2016-11)
      Glucocorticoids are involved in several responses triggered by a variety of environmental and physiological stimuli. These hormones have a wide-range of regulatory effects in organisms. Synthetic glucocorticoids are ...
    • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) 
      Klionsky, Daniel J.; Troncoso Cotal, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Glavic Maurer, Álvaro; Corbalán, Ramón; Matus, Soledad; Segura Aguilar, Juan; Hetz Flores, Claudio (Taylor & Francis inc., 2016)
    • Hyperosmotic stress stimulates autophagy via polycystin-2 
      Peña Oyarzún, Daniel; Troncoso Cotal, Rodrigo; Kretschmar, Catalina; Hernando, Cecilia; Budini, Mauricio; Morselli, Eugenia; Lavandero González, Sergio; Criollo Céspedes, Alfredo (Impact Journals, 2017)
      Various intracellular mechanisms are activated in response to stress, leading to adaptation or death. Autophagy, an intracellular process that promotes lysosomal degradation of proteins, is an adaptive response to several ...
    • Irisin is weakly associated with usual physical activity in young overweight women 
      Tenorio, Beatriz; Jimenez, Teresa; Barrera Acevedo, María Gladys; Hirsch Birn, Sandra; Maza Cave, María Pía de la; Troncoso Cotal, Rodrigo; Farías, María Belén; Rodríguez, Juan Manuel; Bunout Barnett, Daniel (Aula medica ediciones, 2017)
      Purpose: To determine if irisin plasma levels are associated with regular physical activity, body composition and metabolic parameters in women subjected to calorie restriction. Subjects and methods: We studied 42 women ...
    • Mifepristone enhances insulin stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells 
      Bernal Sore, Izela; Navarro Márquez, Mario F.; Osorio Fuentealba, César; Díaz Castro, Francisco; Campo, Andrea del; Donoso Barraza, Camila; Porras Espinoza, Omar; Lavandero González, Sergio; Troncoso Cotal, Rodrigo (Elsevier, 2018)
      Mifepristone is the only FDA-approved drug for glycaemia control in patients with Cushing's syndrome and type 2 diabetes. Mifepristone also has beneficial effects in animal models of diabetes and patients with antipsychotic ...
    • Moderate Aerobic Exercise Training Prevents the Augmented Hepatic Glucocorticoid Response Induced by High-Fat ... 
      Dassonvalle, Jonatan; Díaz Castro, Francisco; Donoso Barraza, Camila; Sepúlveda, Carlos; Pino de la Fuente, Francisco; Pino, Pamela; Espinosa Escalona, Berta; Chiong Lay, Mario; Llanos Silva, Miguel; Troncoso Cotal, Rodrigo (MDPI, 2020)
      Glucocorticoids (GCs) are critical regulators of energy balance. Their deregulation is associated with the development of obesity and metabolic syndrome. However, it is not understood if obesity alters the tissue glucocorticoid ...
    • Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival 
      Campos, Tania; Ziehe, Javiera; Fuentes Villalobos, Francisco; Riquelme, Orlando; Peña, Daniela; Troncoso Cotal, Rodrigo; Lavandero González, Sergio; Morín, Violeta; Pincheira, Roxana; Castro, Ariel F. (Elsevier, 2016)
      Tuberous sclerosis complex (TSC) disease results from inactivation of the TSC1 or TSC2 gene, and is characterized by benign tumors in several organs. Because TSC tumorigenesis correlates with hyperactivation of mTORC1, ...
    • Role of interleukin-6 in vascular health and disease 
      Villar Fincheira, Paulina; Sanhueza Olivares, Fernanda; Norambuena Soto, Ignacio; Cancino Arenas, Nicole; Hernández Vargas, Felipe; Troncoso Cotal, Rodrigo; Gabrielli, Luigi; Chiong Lay, Mario (Frontiers Media, 2021)
      IL-6 is usually described as a pleiotropic cytokine produced in response to tissue injury or infection. As a pro-inflammatory cytokine, IL-6 activates innate and adaptative immune responses. IL-6 is released in the innate ...
    • The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content 
      Shaikh, S.; Troncoso Cotal, Rodrigo; Mondaca Ruff, David; Parra Ortíz, María Valentina; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio (Elsevier, 2018)
      Stromal-interaction molecule 1 (STIM1)-mediated store-operated Ca2+ entry (SOCE) plays a key role in mediating cardiomyocyte hypertrophy, both in vitro and in vivo. Moreover, there is growing support for the contribution ...
    • Trypanosoma cruzi calreticulin: A possible role in Chagas' disease autoimmunity 
      Hager Ribeiro, Carolina; López Bartolucci, Carolina; Ramírez Toloza, Galia; Valck Calderón, Carolina Eliana; Molina, María Carmen; Aguilar, Lorena; Rodríguez, Margarita; Maldonado, Ismael; Martínez, Ramón; González, Carlos; Troncoso Cotal, Rodrigo; Lavandero González, Sergio; Gingras, Alexandre R.; Schwaeble, Wilhelm; Ferreira, Arturo (PERGAMON-ELSEVIER SCIENCE LTD, 2009-03)
      Trypanosoma cruzi (T cruzi) is the causative agent of Chagas' disease, an endemic and chronic illness that affects 18 million people in Latin America. The mechanisms underlying its pathogenesis are controversial. There is ...