Browsing by Author "1937f91a-6cfd-4f70-b0fb-a0fc4768eca3"

Now showing items 1-6 of 6

    • Antiproliferative and uncoupling effects of delocalized, lipophilic, cationic gallic acid derivatives on ... 
      Jara, José A.; Castro Castillo, Vicente; Saavedra-Olavarría, Jorge; Peredo, Liliana; Pavanni, Mario; Jaña, Fabián; Letelier, María Eugenia; Parra, Eduardo; Becker, María Inés; Morello Casté, Antonio; Kemmerling Weis, Ulrike; Maya Arango, Juan; Ferreira, Jorge (American Chemical Society, 2014)
      Tumor cells principally exhibit increased mitochondrial transmembrane potential (Δψm) and altered metabolic pathways. The therapeutic targeting and delivery of anticancer drugs to the mitochondria might improve treatment ...
    • Comparative effects of superoxide anion and hydrogen peroxide on microsomal and cytosolic glutathione ... 
      Letelier, María Eugenia; Molina Berríos, Alfredo Enrique; Cortés-Troncoso, Juan; Jara Sandoval, José; Müller, Andrea; Aracena Parks, Paula (2010)
      Glutathione S-transferases (GSTs) are isoenzymes occurring in the cytoplasm and as integral membrane proteins. In addition to their role in drug metabolism by conjugating electrophilic and lipophilic compounds with glutathione ...
    • Enhanced metabolism of morphine in Octodon degus compared to Wistar rats 
      Letelier Muñoz, María Eugenia; Sánchez, Emilio; Del Villar, Eugenia (1984)
      1. 1. Comparative studies of the actions of morphine in different mammals have shown that Octodon degus presents an unusual tolerance to this compound. 2. 2. Morphine glucuronidation and N-demethylation in microsomal ...
    • Mechanisms underlying iron and copper ions toxicity in biological systems: Pro-oxidant activity and ... 
      Letelier, María Eugenia; Sánchez-Jofré, Sebastián; Peredo-Silva, Liliana; Cortés-Troncoso, Juan; Aracena-Parks, Paula (2010)
      Iron and copper ions, in their unbound form, may lead to the generation of reactive oxygen species via Haber-Weiss and/or Fenton reactions. In addition, it has been shown that copper ions can irreversibly and non-specifically ...
    • Melatonin protects the cytochrome P450 system through a novel antioxidant mechanism 
      Letelier, María Eugenia; Jara Sandoval, José; Molina Berríos, Alfredo Enrique; Faúndez, Mario; Aracena-Parks, Paula; Aguilera, Felipe (2010)
      Melatonin, an endogenous hormone, is used as an antioxidant drug in doses quite higher than the endogenous circulating levels of this hormone. Hepatic endoplasmic reticulum contains the cytochrome P450 (CYP450) system, ...
    • Topical anti-inflammatory activity of 2α-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae 
      Aguirre, María C.; Delporte, Carla; Backhouse, Nadine; Erazo, Silvia; Letelier, María Eugenia; Cassels Niven, Bruce; Silva, Ximena; Alegría, Sergio; Negrete, Rosa (2006)
      Leaf extracts of Ugni molinae Turcz. are used in the Chilean cosmetic industry on the assumption that they have decongestant, regenerative, and anti-aging properties. A bioassay-guided fractionation of this plant material ...