Browsing by Author "19aed480-3ff1-45ad-b4d3-5ec9fb3aa8b9"

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    • A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington's disease in mice 
      Acuña, Aníbal I.; Esparza, Magdalena; Kramm, Carlos; Beltrán, Felipe A.; Parra, Alejandra V.; Cepeda, Carlos; Toro, Carlos A.; Vidal, René L.; Hetz Flores, Claudio; Concha, Ilona I.; Brauchi, Sebastián; Levine, Michael S.; Castro, Maite A. (Nature Publishing Group, 2013)
      Huntington's disease has been associated with a failure in energy metabolism and oxidative damage. Ascorbic acid is a powerful antioxidant highly concentrated in the brain where it acts as a messenger, modulating neuronal ...
    • RCAN1 knockdown reverts defects in the number of calcium-induced exocytotic events in a cellular model of ... 
      Vásquez Navarrete, Jacqueline; Martínez, Agustín; Ory, Stephane; Báez Matus, Ximena; González Jamett, Arlek M.; Brauchi, Sebastián; Caviedes, Pablo; Cárdenas, Ana María (Frontiers Media, 2018-07-06)
      In humans, Down Syndrome (DS) is a condition caused by partial or full trisomy of chromosome 21. Genes present in the DS critical region can result in excess gene dosage, which at least partially can account for DS phenotype. ...