Browsing by Author "1a3c6b39-25c3-47d6-8eed-3a5ec8ab9733"

Now showing items 1-12 of 12

    • A heat-shocked melanoma cell lysate vaccine enhances tumor infiltration by prototypic effector T cells ... 
      Gleisner Muñoz, María Alejandra; Pereda Ramos, Cristián; Tittarelli Elaskar, Andrés; Navarrete Sánchez, Mariela; Fuentes Villegas, Camila; Ávalos, Ignacio; Tempio Sepúlveda, Fabián; Araya, Juan Pablo; Becker, María Inés; González Bergas, Fermín; López Nitsche, Mercedes; Salazar Onfray, Flavio (BMJ, 2020)
      Background Immune checkpoint blocker (ICB) therapy has shown survival benefits for some patients with cancer. Nevertheless, many individuals remain refractory or acquire resistance to treatment, motivating the exploration of ...
    • Comparative EST transcript profiling of peach fruits under different post-harvest conditions reveals candidate ... 
      Vizoso, Paula; Meisel, Lee A.; Tittarelli, Andrés; Latorre, Mariano; Saba, Juan; Caroca, Rodrigo; Maldonado, Jonathan; Cambiazo Ayala, Verónica; Campos Vargas, Reinaldo; González, Mauricio; Orellana, Ariel; Silva Ascencio, Herman (2009)
      Background: Cold storage is used to inhibit peach fruit ripening during shipment to distant markets. However, this cold storage can negatively affect the quality of the fruit when it is ripened, resulting in disorders ...
    • Connexin-Mediated Signaling at the Immunological Synapse 
      Tittarelli, Andrés; Navarrete, Mariela; Gleisner, María Alejandra; Gebicke Härter, Peter; Salazar Onfray, Flavio (MDPI, 2020)
      The immunological synapse (IS) is an intercellular communication platform, organized at the contact site of two adjacent cells, where at least one is an immune cell. Functional IS formation is fundamental for the modulation ...
    • Dexamethasone turns tumor antigen-presenting cells into tolerogenic dendritic cells with T cell inhibitory ... 
      Falcón Beas, Cristián; Tittarelli, Andrés; Mora-Bau, Gabriela; Tempio, Fabián; Pérez Núñez, Claudio; Hevia, Daniel; Behrens, Carolina; Flores, Iván; Falcón-Beas, Felipe; Garrido, Paola; Ascui, Gabriel; Pereda, Cristián; González, Fermín E.; Salazar Onfray, Flavio; López, Mer (Elsevier GmbH, 2019)
      Background: Dendritic cells (DCs) are usually immunogenic, but they are also capable of inducing tolerance under anti-inflammatory conditions. Immunotherapy based on autologous DCs loaded with an allogeneic melanoma cell ...
    • Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation 
      Mendoza Naranjo, Ariadna; Bouma, Gerben; Pereda, Cristián; Ramiŕez, Marcos; Webb, Kevin F.; Tittarelli, Andrés; Loṕez, Mercedes N.; Kalergis, Alexis M.; Thrasher, Adrian J.; Becker, David L.; Salazar Onfray, Flavio (2011)
      Gap junction (GJ) mediates intercellular communication through linked hemichannels from each of two adjacent cells. Using human and mouse models, we show that connexin 43 (Cx43), the main GJ protein in the immune system, ...
    • High CD8(+) and absence of Foxp3(+) T lymphocytes infiltration in gallbladder tumors correlate with prolonged ... 
      Fluxá Rojas, Paula; Rojas Sepúlveda, Daniel; Gleisner, María Alejandra; Tittarelli, Andrés; Villegas, Pablo; Tapia, Loreto; Rivera, María Teresa; López Nitsche, Mercedes; Catán, Felipe; Uribe Maturana, Mario; Salazar Onfray, Flavio (BIOMED Central Ltd., 2018)
      Background: Gallbladder cancer (GBC), although infrequent in industrialized countries, has high incidence rates in certain world regions, being a leading cause of death among elderly Chilean women. Surgery is the only ...
    • Hypoxic Melanoma Cells Deliver microRNAs to Dendritic Cells and Cytotoxic T Lymphocytes through Connexin-43 ... 
      Tittarelli, Andrés; Navarrete, Mariela; Lizana, Marcelo; Hofmann Vega, Francisca; Salazar Onfray, Flavio (MDPI, 2020)
      Alterations in microRNA (miRNA) profiles, induced by tumor microenvironment stressors, like hypoxia, allow cancer cells to acquire immune-resistance phenotypes. Indeed, hypoxia-induced miRNAs have been implicated in cancer ...
    • The immunological response and post-treatment survival of DC-vaccinated melanoma patients are associated ... 
      Durán Aniotz, Claudia; Segal, Gabriela; Salazar, Lorena; Pereda, Cristián; Falcón, Cristián; Tempio, Fabián; Aguilera, Raquel; González González, Rodrigo; Pérez Núñez, Claudio; Tittarelli, Andrés; Catalán Martina, Diego; Nervi, Bruno; Larrondo Lillo, Milton; Salazar Onfray, Flavio; López Nitsche, Mercedes (Springer, 2013)
      Introduction Immunization with autologous dendritic cells (DCs) loaded with a heat shock-conditioned allogeneic melanoma cell lysate caused lysate-specific delayed type hypersensitivity (DTH) reactions in a number ...
    • Mind the gaps in tumor immunity: impact of connexin mediated intercellular connections 
      Gleisner, María Alejandra; Navarrete, Mariela; Hofmann, Francisca; Salazar Onfray, Flavio; Tittarelli, Andrés (Frontiers media SA, 2017)
      Gap junctions (GJs)-mediated intercellular communications (GJICs) are connexin (Cx)-formed plasma membrane channels that allow for the passage of small molecules between adjacent cells, and are involved in several ...
    • Molecular signatures associated with tumor-specific immune response in melanoma patients treated with ... 
      García-Salum, Tamara; Villablanca, Andrea; Matthäus, Franziska; Tittarelli, Andrés; Baeza, Mauricio; Pereda, Cristián; Gleisner Muñoz, María Alejandra; González, Fermín; López, Mercedes; Hoheisel, Jörg; Norgauer, Johannes; Gebicke Haerter, Peter; Salazar Onfray, Flavio (Impact Journals LLC, 2018)
      Purpose: We previously showed that autologous dendritic cells (DCs) loaded with an allogeneic heat shock (HS)-conditioned melanoma cell-derived lysate, called TRIMEL, induce T-cell-mediated immune responses in stage IV ...
    • Toll-like receptor 4 gene polymorphism influences dendritic cell in vitro function and clinical outcomes ... 
      Tittarelli, Andrés; González, Fermín E.; Pereda, Cristián; Mora, Gabriela; Muñoz, Leonel; Saffie, Carlos; García, Tamara; Díaz, David; Falcón, Cristián; Hermoso, Marcela; López, Mercedes N.; Salazar Onfray, Flavio (2012)
      Toll-like receptor 4 (TLR4) is expressed on dendritic cells (DCs), sensing environmental danger molecules that induce their activation and maturation. Recently, we reported a method for the production of therapeutic DCs ...
    • Tumor lysate-based vaccines: on the road to immunotherapy for gallbladder cancer 
      Rojas-Sepúlveda, Daniel; Tittarelli, Andrés; Gleisner, María Alejandra; Ávalos, Ignacio; Pereda, Cristián; Gallegos, Iván; González, Fermín Eduardo; López, Mercedes Natalia; Butte, Jean Michel; Roa, Juan; Fluxá, Paula; Salazar Onfray, Flavio (Springer Science and Business Media Deutschland GmbH, 2018)
      © 2018, The Author(s). Immunotherapy based on checkpoint blockers has proven survival benefits in patients with melanoma and other malignancies. Nevertheless, a significant proportion of treated patients remains refractory, ...