Browsing by Author "1a442867-e261-44b2-9758-61fb388c1259"
Now showing items 1-9 of 9
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Contreras, Gustavo F.; Castillo, Karen; Enrique, Nicolás; Carrasquel Ursulaez, Willy; Castillo, Juan Pablo; Milesi, Verónica; Neely, Alan; Alvarez, Osvaldo; Ferreira, Gonzalo; Gonzalez, Carlos; Latorre, Ramón (Taylor and Francis Inc., 2013)Calcium and voltage-activated potassium (BK) channels are key actors in cell physiology, both in neuronal and non-neuronal cells and tissues. Through negative feedback between intracellular Ca2+ and membrane voltage, BK ...
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Nassif, Melissa; Matus, Soledad; Castillo, Karen; Hetz Flores, Claudio (2010)Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motoneuron degenerative disease characterized by the selective loss of motoneurons in the spinal ventral horn, most brainstem nuclei, and the cerebral ...
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BAX inhibitor-1 regulates autophagy by controlling the IRE1α branch of the unfolded protein response Castillo, Karen; Rojas Rivera, Diego; Lisbona, Fernanda; Caballero, Benjamín; Nassif, Melissa; Court, Felipe A.; Schuck, Sebastian; Ibar, Consuelo; Walter, Peter; Sierralta, Jimena; Glavic Maurer, Álvaro; Hetz Flores, Claudio (2011)Both autophagy and apoptosis are tightly regulated processes playing a central role in tissue homeostasis. Bax inhibitor 1 (BI-1) is a highly conserved protein with a dual role in apoptosis and endoplasmic reticulum (ER) ...
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Matus, Soledad; Castillo, Karen; Hetz Flores, Claudio (Taylor and Francis Inc., 2012)Protein folding stress is a salient feature of the most frequent neurodegenerative diseases. Although the accumulation of abnormally folded proteins is a well-characterized event underlying the pathology, the way cells ...
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Nassif, Melissa; Valenzuela, Vicente; Rojas Rivera, Diego; Vidal, René; Matus, Soledad; Castillo, Karen; Fuentealba, Yerko; Kroemer, Guido; Levine, Beth; Hetz Flores, Claudio (Taylor and Francis Inc., 2014)Pharmacological activation of autophagy is becoming an attractive strategy to induce the selective degradation of aggregate-prone proteins. Recent evidence also suggests that autophagy impairment may underlie the pathogenesis ...
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Torres, Mauricio; Castillo, Karen; Armisen Yáñez, Ricardo; Stutzin Schottlander, Andrés; Soto, Claudio; Hetz Flores, Claudio (2010)Prion-related disorders (PrDs) are fatal neurodegenerative disorders characterized by progressive neuronal impairment as well as the accumulation of an abnormally folded and protease resistant form of the cellular prion ...
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Carmona, Emerson M.; Baez Nieto, David; Pupo, Amaury; Castillo, Karen; Álvarez Araya, Osvaldo; Neely, Alan; Latorre, Ramón; González, Carlos (Cell Press, 2018)
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Saavedra, María Verónica; Smalla, Karl Heinz; Thomas, Ulrich; Sandoval, Soledad; Olavarria, Karel; Castillo, Karen; Delgado, María Graciela; Delgado, Ricardo; Gundelfinger, Eckart D.; Bacigalupo Vicuña, Juan; Wyneken, Ursula (2008)Odour-mediated signal transduction is a complex process that occurs in the cilia of olfactory sensory neurons. To gain insight in to the molecular organization of the odour transduction machinery, we developed a procedure ...
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Ramírez Barrantes, Ricardo; Carvajal Zamorano, Karina; Rodríguez, Belén; Córdova, Claudio; Lozano, Carlo; Simón, Felipe; Díaz, Paula; Muñoz, Pablo; Marchant, Ivanny; Latorre, Ramón; Castillo, Karen; Olivero, Pablo (Frontiers Media, 2020)17 beta-estradiol is a neuronal survival factor against oxidative stress that triggers its protective effect even in the absence of classical estrogen receptors. The polymodal transient receptor potential vanilloid subtype ...