Browsing by Author "1b35adb9-4374-493c-bb7c-1a96506daaf1"

Now showing items 1-15 of 15

    • A short hairpin RNA-based adjuvant targeting NF-kappa B repressor I kappa B alpha promotes migration of ... 
      Gálvez Cancino, Felipe; Roco, Jonathan; Rojas Colonelli, Nicole; Flores, Camila; Murgas, Paola; Cruz Gómez, Sebastián; Oyarce, Cesar; Varas Godoy, Manuel; Sauma Mahaluf, Daniela; Lladser, Álvaro (Elsevier, 2017)
      DNA vaccination is an attractive approach to elicit tumor-specific cytotoxic CD8(+) T lymphocytes (CTL), which can mediate protective immunity against tumors. To initiate CTL responses, antigen-encoding plasmids employed ...
    • Adoptive transfer of autoimmune splenic dendritic cells to lupus-prone mice triggers a B lymphocyte humoral ... 
      Sauma Mahaluf, Daniela; Crisóstomo, Natalia; Fuentes, Camila; Gleisner, María Alejandra; Hidalgo, Yessia; Fuenzalida, María José; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (Springer, 2017)
      Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by increased autoantibody production that leads to multiple tissue injuries. Dendritic cells (DCs) are important orchestrators of immune responses ...
    • Cyclosporin a-treated dendritic cells may affect the outcome of organ transplantation by decreasing CD4+CD25+ ... 
      Pino Lagos, Karina; Michea, Paula; Sauma Mahaluf, Daniela; Alba, Andrea; Morales, Jorge; Bono Merino, María Rosa; Fierro, Alberto; Rosemblatt Silber, Mario César (Society of Biology of Chile, 2010)
      One of the mechanisms for generation of tolerance involves immature dendritic cells (DCs) and a subpopulation of regulatory CD4+ CD25+ T lymphocytes (TREG). The purpose of this work was to analyze how Cyclosporine A (CsA), ...
    • Dead tumor cells expressing infectious salmon anemia virus fusogenic protein favor antigen cross-priming in vitro 
      Morales, Jonathan; Barrera Avalos, Carlos; Castro, Carlos; Castillo, Stephanie; Barrientos, Claudio; Robles Planells, Claudia; López, Ximena; Torres, Ernesto; Montoya, Margarita; Cortez San Martin, Marcelo; Riquelme, Denise; Escobar Álvarez, Alejandro; Fernández, Ricardo; Imarai, Mónica; Sauma Mahaluf, Daniela; Rojo, Leonel E.; Leiva Salcedo, Elias; Acuña Castillo, Claudio (Frontiers media SA, 2017)
      Antigen cross-presentation is a crucial step in the assembly of an antitumor immune response leading to activation of naive CD8 T cells. This process has been extensively used in clinical trials, in which dendritic cells ...
    • Dendritic Cells and B Cells Cooperate in the Generation of CD4+CD25+FOXP3+ Allogeneic T Cells 
      Moore, C.; Sauma Mahaluf, Daniela; Reyes, P. A.; Morales, J.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Fierro, J. A. (2010)
      Background: CD4+CD25+Foxp3+ regulatory T cells (Treg) play an essential role in immune tolerance, suppressing responses against self-antigens. Additionally, Treg play an important role in maintaining immunosuppression to ...
    • Dendritic cells and the mode of action of anticalcineurinic drugs: An integrating hypothesis 
      Fierro, Alberto; Mora, J. Rodrigo; Bono Merino, María Rosa; Morales, Jorge; Buckel, Erwin; Sauma Mahaluf, Daniela; Rosemblatt Silber, Mario César (2003)
    • Differential regulation of Notch ligands in dendritic cells upon interaction with T helper cells 
      Sauma Mahaluf, Daniela; Espejo, P.; Ramirez, A.; Fierro, A.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2011)
      The Notch signalling pathway has recently been linked to T helper 1 (Th1)/T helper 2 (Th2) cell polarization via a mechanism involving differential expression of Notch ligands, Delta-like and Jagged, in antigen-presenting ...
    • In Vitro-generated Tc17 cells Present a Memory Phenotype and serve as a reservoir of Tc1 cells In Vivo 
      Flores Santibañez, Felipe; Cuadra, Barbara; Fernández, Dominique; Rosemblatt, María V.; Nunez, Sarah; Cruz, Pablo; Gálvez Cancino, Felipe Ignacio; Cárdenas, J.C.; Lladser, Álvaro; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Sauma Mahaluf, Daniela (Frontiers Media SA, 2018)
      Memory CD8(+) T cells are ideal candidates for cancer immunotherapy because they can mediate long-term protection against tumors. However, the therapeutic potential of different in vitro-generated CD8(+) T cell effector ...
    • Low-dose prednisone accounts for a transient reduction on CD4+ and CD8+ T cells in renal transplant patients ... 
      Sauma Mahaluf, Daniela; Mora, J. R.; Fierro, Alberto; Morales, J.; Herzog, C.; Buckel, E.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2002)
    • Notch Signalling Regulates Cytokine Production by CD8+ and CD4+ T Cells 
      Sauma Mahaluf, Daniela; Ramirez, A.; Alvarez, K.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2012)
      The Notch signalling pathway regulates several aspects of cellular differentiation such as T lineage commitment and effector functions on peripheral T cells; however, there is limited information regarding Notch receptor ...
    • P2X7 receptor at the crossroads of T cell fate 
      Rivas Yáñez, Elizabeth; Barrera Ávalos, Carlos; Parra Tello, Brian; Briceño, Pedro F.; Rosemblatt, Mariana V.; Saavedra Almarza, Juan Pablo; Rosemblatt Silber, Mario; Acuña Castillo, Claudio; Bono Merino, María Rosa; Sauma Mahaluf, Daniela (MDPI, 2020)
      The P2X7 receptor is a ligand-gated, cation-selective channel whose main physiological ligand is ATP. P2X7 receptor activation may also be triggered by ARTC2.2-dependent ADP ribosylation in the presence of extracellular ...
    • Retinoic Acid as a Modulator of T Cell Immunity 
      Bono Merino, María Rosa; Tejón, Gabriela; Flores Santibáñez, Felipe; Fernández, Dominique; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela (MDPI, 2016)
      Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual ...
    • Retinoic acid generates regulatory T cells in experimental transplantation 
      Moore, C.; Fuentes C., Claudio; Sauma Mahaluf, Daniela; Morales, J.; Bono Merino, María Rosa; Rosemblatt Silber, Mario César; Fierro, J. A. (2011)
      Regulatory T cells play a key role to inhibit effector lymphocytes, avoid, autoimmunity, and restrain allogeneic immunity. Retinoic acid is an important cofactor that stimulates the generation and expansion of regulatory ...
    • Role of PD-L2 in B lymphocytes during the development of lupus 
      Hidalgo, Y.; Fuenzalida, M. J.; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela; Bono Merino, María Rosa (2016)
    • Transforming Growth Factor-β and All-Trans Retinoic Acid Generate Ex Vivo Transgenic Regulatory T Cells ... 
      Moore, C.; Sauma Mahaluf, Daniela; Morales, J.; Bono Merino, María Rosa; Rosemblatt Silber, Mario César; Fierro, J. A. (2009)
      CD4+CD25+Foxp3+ regulatory T cells (Treg) mediate immunologic self-tolerance and suppress immune responses. In the gut, a subset of dendritic cells is specialized to induce Treg in a transforming growth factor-β (TGF-β)- ...