Now showing items 1-16 of 16

    • Gálvez Cancino, Felipe; Roco, Jonathan; Rojas Colonelli, Nicole; Flores, Camila; Murgas, Paola; Cruz Gómez, Sebastián; Oyarce, Cesar; Varas Godoy, Manuel; Sauma Mahaluf, Daniela; Lladser, Álvaro (Elsevier, 2017)
      DNA vaccination is an attractive approach to elicit tumor-specific cytotoxic CD8(+) T lymphocytes (CTL), which can mediate protective immunity against tumors. To initiate CTL responses, antigen-encoding plasmids employed ...
    • Gálvez Cancino, Felipe Ignacio; Roco, Jonathan; Rojas Colonelli, Nicole; Flores, Camila; Murgas, Paola; Cruz Gómez, Sebastián; Oyarce, César; Varas Godoy, Manuel; Sauma Mahaluf, Daniela; Lladser, Álvaro (Elsevier Ltd, 2017)
      © 2017 Elsevier Ltd DNA vaccination is an attractive approach to elicit tumor-specific cytotoxic CD8+ T lymphocytes (CTL), which can mediate protective immunity against tumors. To initiate CTL responses, antigen-encoding ...
    • Sauma Mahaluf, Daniela; Crisóstomo, Natalia; Fuentes, Camila; Gleisner, María Alejandra; Hidalgo, Yessia; Fuenzalida, María José; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (Springer, 2017)
      Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by increased autoantibody production that leads to multiple tissue injuries. Dendritic cells (DCs) are important orchestrators of immune responses ...
    • Pino Lagos, Karina; Michea, Paula; Sauma Mahaluf, Daniela; Alba, Andrea; Morales, Jorge; Bono Merino, María Rosa; Fierro, Alberto; Rosemblatt Silber, Mario César (Society of Biology of Chile, 2010)
      One of the mechanisms for generation of tolerance involves immature dendritic cells (DCs) and a subpopulation of regulatory CD4+ CD25+ T lymphocytes (TREG). The purpose of this work was to analyze how Cyclosporine A (CsA), ...
    • Morales, Jonathan; Barrera Avalos, Carlos; Castro, Carlos; Castillo, Stephanie; Barrientos, Claudio; Robles Planells, Claudia; López, Ximena; Torres, Ernesto; Montoya, Margarita; Cortez San Martin, Marcelo; Riquelme, Denise; Escobar Álvarez, Alejandro; Fernández, Ricardo; Imarai, Mónica; Sauma Mahaluf, Daniela; Rojo, Leonel E.; Leiva Salcedo, Elias; Acuña Castillo, Claudio (Frontiers media SA, 2017)
      Antigen cross-presentation is a crucial step in the assembly of an antitumor immune response leading to activation of naive CD8 T cells. This process has been extensively used in clinical trials, in which dendritic cells ...
    • Moore, C.; Sauma Mahaluf, Daniela; Reyes, P. A.; Morales, J.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Fierro, J. A. (2010)
      Background: CD4+CD25+Foxp3+ regulatory T cells (Treg) play an essential role in immune tolerance, suppressing responses against self-antigens. Additionally, Treg play an important role in maintaining immunosuppression to ...
    • Fierro, Alberto; Mora, J. Rodrigo; Bono Merino, María Rosa; Morales, Jorge; Buckel, Erwin; Sauma Mahaluf, Daniela; Rosemblatt Silber, Mario César (2003)
    • Sauma Mahaluf, Daniela; Espejo, P.; Ramirez, A.; Fierro, A.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2011)
      The Notch signalling pathway has recently been linked to T helper 1 (Th1)/T helper 2 (Th2) cell polarization via a mechanism involving differential expression of Notch ligands, Delta-like and Jagged, in antigen-presenting ...
    • Flores Santibañez, Felipe; Cuadra, Barbara; Fernández, Dominique; Rosemblatt, María V.; Nunez, Sarah; Cruz, Pablo; Gálvez Cancino, Felipe Ignacio; Cárdenas, J.C.; Lladser, Álvaro; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Sauma Mahaluf, Daniela (Frontiers Media SA, 2018)
      Memory CD8(+) T cells are ideal candidates for cancer immunotherapy because they can mediate long-term protection against tumors. However, the therapeutic potential of different in vitro-generated CD8(+) T cell effector ...
    • Sauma Mahaluf, Daniela; Mora, J. R.; Fierro, Alberto; Morales, J.; Herzog, C.; Buckel, E.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2002)
    • Sauma Mahaluf, Daniela; Ramirez, A.; Alvarez, K.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2012)
      The Notch signalling pathway regulates several aspects of cellular differentiation such as T lineage commitment and effector functions on peripheral T cells; however, there is limited information regarding Notch receptor ...
    • Rivas Yáñez, Elizabeth; Barrera Ávalos, Carlos; Parra Tello, Brian; Briceño, Pedro F.; Rosemblatt, Mariana V.; Saavedra Almarza, Juan Pablo; Rosemblatt Silber, Mario; Acuña Castillo, Claudio; Bono Merino, María Rosa; Sauma Mahaluf, Daniela (MDPI, 2020)
      The P2X7 receptor is a ligand-gated, cation-selective channel whose main physiological ligand is ATP. P2X7 receptor activation may also be triggered by ARTC2.2-dependent ADP ribosylation in the presence of extracellular ...
    • Bono Merino, María Rosa; Tejón, Gabriela; Flores Santibáñez, Felipe; Fernández, Dominique; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela (MDPI, 2016)
      Vitamin A, a generic designation for an array of organic molecules that includes retinal, retinol and retinoic acid, is an essential nutrient needed in a wide array of aspects including the proper functioning of the visual ...
    • Moore, C.; Fuentes C., Claudio; Sauma Mahaluf, Daniela; Morales, J.; Bono Merino, María Rosa; Rosemblatt Silber, Mario César; Fierro, J. A. (2011)
      Regulatory T cells play a key role to inhibit effector lymphocytes, avoid, autoimmunity, and restrain allogeneic immunity. Retinoic acid is an important cofactor that stimulates the generation and expansion of regulatory ...
    • Hidalgo, Y.; Fuenzalida, M. J.; Rosemblatt Silber, Mario César; Sauma Mahaluf, Daniela; Bono Merino, María Rosa (2016)
    • Moore, C.; Sauma Mahaluf, Daniela; Morales, J.; Bono Merino, María Rosa; Rosemblatt Silber, Mario César; Fierro, J. A. (2009)
      CD4+CD25+Foxp3+ regulatory T cells (Treg) mediate immunologic self-tolerance and suppress immune responses. In the gut, a subset of dendritic cells is specialized to induce Treg in a transforming growth factor-β (TGF-β)- ...