Browsing by Author "1c6af315-b6b5-4350-953b-12591c3cf6f7"

Now showing items 1-6 of 6

    • Antiangiogenic and antitumor effects of trypanosoma cruzi Calreticulin 
      López, Nandy C.; Valck, Carolina; Ramírez, Galia; Rodríguez, Margarita; Ribeiro, Carolina; Orellana, Juana; Maldonado, Ismael; Albini, Adriana; Anacona, Daniel; Lemus, David; Aguilar, Lorena; Schwaeble, Wilhelm; Ferreira, Arturo (2010)
      Background: In Latin America, 18 million people are infected with Trypanosoma cruzi, the agent of Chagas' disease, with the greatest economic burden. Vertebrate calreticulins (CRT) are multifunctional, intra- and extracellular ...
    • Comparative in vivo antiangiogenic effects of calreticulin from Trypanosoma cruzi and Homo sapiens sapiens 
      Toledo, Víctor; Ramírez, Galia; Valck, Carolina; López, Nandy; Ribeiro, Carolina H.; Maldonado, Ismael; Aguilar, Lorena; Lemus, David; Ferreira, Arturo (Society of Biology of Chile, 2010)
      Angiogenesis is a complex multi-step process of neovascularization arising from preexisting blood vessels whose generation is regulated by pro- and anti-angiogenic factors. Both Trypanosoma cruzi calreticulin (TcCRT) and ...
    • F(ab')2 antibody fragments against Trypanosoma cruzi calreticulin inhibit its interaction with the first ... 
      Aguilar, Lorena; Ramírez, Galia; Valck, Carolina; Molina, María C.; Rojas, Álvaro; Schwaeble, Wilhelm; Ferreira, Viviana; Ferreira, Arturo (Society of Biology of Chile, 2005)
      Trypanosoma cruzi calreticulin (TcCRT), described in our laboratory, retains several important functional features from its vertebrate homologues. We have shown that recombinant TcCRT inhibits the human complement system ...
    • The Interactions of Parasite Calreticulin With Initial Complement Components: Consequences in Immunity and ... 
      Ramírez Toloza, Galia; Aguilar Guzmán, Lorena Andrea; Valck, Carolina; Ferreira, Viviana P.; Ferreira, Arturo (Frontiers Media, 2020)
      Because of its capacity to increase a physiologic inflammatory response, to stimulate phagocytosis, to promote cell lysis and to enhance pathogen immunogenicity, the complement system is a crucial component of both the ...
    • Trypanosoma cruzi calreticulin inhibits the complement lectin pathway activation by direct interaction with ... 
      Sosoniuk, Eduardo; Vallejos, Gerardo; Kenawy, Hany; Gaboriaud, Christine; Thielens, Nicole; Fujita, Teizo; Schwaeble, Wilhelm; Ferreira, Arturo; Valck, Carolina (Elsevier Ltd, 2014)
      Trypanosoma cruzi, the agent of Chagas' disease, the sixth neglected tropical disease worldwide, infects 10-12 million people in Latin America. Differently from T. cruzi epimastigotes, trypomastigotes are complement-resistant ...
    • Trypanosoma cruzi calreticulin topographical variations in parasites infecting murine macrophages 
      González, Andrea; Valck, Carolina; Sánchez, Gittith; Härtel, Steffen; Mansilla, Jorge; Ramírez, Galia; Fernández, María Soledad; Arias, José; Galanti Garrone, Norbel; Ferreira, Arturo (American Society of Tropical Medicine and Hygiene, 2015)
      Trypanosoma cruzi calreticulin (TcCRT), a 47-kDa chaperone, translocates from the endoplasmic reticulum to the area of flagellum emergence. There, it binds to complement components C1 and mannan-binding lectin (MBL), thus ...