Browsing by Author "1d861d99-ad90-4fa4-828f-544061873577"

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    • Chronic bryostatin‑1 rescues autistic and cognitive phenotypes in the fragile X mice 
      Cogram, Patricia; Alkon, Daniel L.; Crockford, David; Deacon, Robert M.J.; Hurley, Michael J.; Altimiras, Francisco; Sun, Miao‑Kun; Tranfaglia, Michael (Nature, 2020)
      Fragile X syndrome (FXS), an X-chromosome linked intellectual disability, is the leading monogenetic cause of autism spectrum disorder (ASD), a neurodevelopmental condition that currently has no specific drug treatment. ...
    • Multiple behavior phenotypes of the fragile - X syndrome mouse model respond to chronic inhibition of ... 
      Gurney, Mark E.; Cogram, Patricia; Deacon, Robert M.; Rex, Christopher; Tranfaglia, Michael (Nature Publishing Group, 2017)
      Fragile-X syndrome (FXS) patients display intellectual disability and autism spectrum disorder due to silencing of the X-linked, fragile-X mental retardation-1 (FMR1) gene. Dysregulation of cAMP metabolism is a consistent ...