Browsing by Author "1e7a4be1-8b7d-443d-aac2-aca8c81d31db"
Now showing items 1-12 of 12
-
Martínez, Gabriela; Hetz Flores, Claudio (2012)
-
Martínez, Gabriela; Durán Aniotz, Claudia; Cabral Miranda, Felipe; Hetz Flores, Claudio (Frontiers Media, 2016)
-
Zulantay Alfaro, Inés; Apt Baruch, Werner; Valencia, Claudio; Torres, Alberto; Saavedra, Miguel; Sánchez Rodríguez, Jorge E.; Sandoval, Lea; Martínez, Gabriela; Thieme, Patricio; Sepúlveda, Eduardo (2011)Objectives: This study compared three parasitological methods applied simultaneously in individuals with untreated chronic Chagas' disease in order to determine their individual and combined performances. Methods: From a ...
-
Martínez Bravo, Gabriela; Durán Aniotz, Claudia; Cabral Miranda, Felipe; Vivar, Juan P.; Hetz Flores, Claudio (Blackwell, 2017)Perturbed neuronal proteostasis is a salient feature shared by both aging and protein misfolding disorders. The proteostasis network controls the health of the proteome by integrating pathways involved in protein synthesis, ...
-
Martínez, Gabriela; Khatiwada, Sanjeev; Costa-Mattioli, Mauro; Hetz Flores, Claudio (Elsevier Ltd, 2018)© 2018 Elsevier Ltd Neuronal proteostasis is maintained by the dynamic integration of different processes that regulate the synthesis, folding, quality control, and localization of proteins. The endoplasmic reticulum (ER) ...
-
Muñoz, Catalina; Zuntalay Alfaro, Inés Adriana; Apt Baruch, Werner; Ortiz Zúñiga, Sylvia; Schijman, Alejandro G.; Bisio, Margarita; Ferrada, Valentina; Herrera, Cinthya; Martínez, Gabriela; Solari Illescas, Aldo (American Society for Microbiology, 2013-09)Currently, evaluation of drug efficacy for Chagas disease remains a controversial issue with no consensus. In this work, we evaluated the parasitological efficacy of Nifurtimox treatment in 21 women with chronic Chagas ...
-
Valenzuela, Vicente; Martínez, Gabriela; Durán Aniotz, Claudia; Hetz Flores, Claudio (Elsevier B.V., 2016)© 2016 Elsevier B.V. Gene therapy based on the use of Adeno-associated viruses (AAVs) is emerging as a safe and stable strategy to target molecular pathways involved in a variety of brain diseases. Endoplasmic reticulum ...
-
Klein, Andres; Mosqueira, Matías; Martínez, Gabriela; Robledo, Fermín; González, Marcela; Caballero, Benjamín; Cancino, Gonzalo I.; Alvarez, Alejandra R.; Hetz Flores, Claudio; Zanlungo, Silvana (2011)Background: Niemann-Pick type C (NPC) disease is a fatal lysosomal storage disease related to progressive neurodegeneration secondary to abnormal intracellular accumulation of cholesterol. Signs of endoplasmic reticulum ...
-
Durán Aniotz, Claudia; Martínez, Gabriela; Hetz Flores, Claudio (Frontiers Media SA, 2014)
-
Saavedra, Miguel; Zulantay Alfaro, Inés; Apt Baruch, Werner; Castillo, Juan; Araya, Eduardo; Martínez, Gabriela; Sánchez Rodríguez, Jorge E. (BioMed Central Ltd., 2016)© 2016 The Author(s).Background: Trypanosoma cruzi multiplies and differentiates in the digestive tract of triatomine insects. Xenodiagnosis (XD) is a parasitological tool in which the insect vectors acts as a biological ...
-
Muñoz, Gabriela; Vergara, Camilo; Martínez, Gabriela; Apt, Werner; Zulantay, Inés (Korean Society for Parasitology and Tropical Medicine, 2019)In the indeterminate chronic period of Chagas disease (ChD) the treatment has not been conclusive, because the serological negativization requires many years. This study aims to evaluate the efficacy of nifurtimox (NF) in ...
-
Bravo, Nicolás; Mũoz, Catalina; Nazal, Nicolás; Saavedra, Miguel; Martínez, Gabriela; Acha Araya, Eduardo Javier; Apt Baruch, Werner; Zulantay Alfaro, Inés (2012)Background: The polymerase chain reaction (PCR) has proved to be a sensitive technique to detect Trypanosoma cruzi in the chronic phase of Chagas disease, which is characterized by low and fluctuating parasitemia. Another ...