Browsing by Author "1f4405df-6e3d-401e-97f9-72d00c192c95"

Now showing items 1-4 of 4

    • Impaired cell cycle regulation of the osteoblast-related heterodimeric transcription factor Runx2-Cbfβ in ... 
      San Martin, Inga A.; Varela, Nelson; Gaete, Marcia; Villegas, Karina; Osorio, Mariana; Tapia, Julio; Antonelli, Marcelo; Mancilla, Edna E.; Pereira, Barry P.; Nathan, Saminathan S.; Lian, Jane B.; Stein, Janet L.; Stein, Gary S.; Van Wijnen, Andre J.; Galindo, Mario A. (2009)
      Bone formation and osteoblast differentiation require the functional expression of the Runx2/Cbfβ heterodimeric transcription factor complex. Runx2 is also a suppressor of proliferation in osteoblasts by attenuating cell ...
    • Mitotic retention of gene expression patterns by the cell fate-determining transcription factor Runx2 
      Young, Daniel W.; Hassan, Mohammad Q.; Yang, Xiao Qing; Galindo, Mario A.; Javed, Amjad; Zaidi, Sayyed K.; Furcinitti, Paul; Lapointe, David; Montecino, Martín; Lian, Jane B.; Stein, Janet L.; Van Wijnen, Andre J.; Stein, Gary S. (2007)
      During cell division, cessation of transcription is coupled with mitotic chromosome condensation. A fundamental biological question is how gene expression patterns are retained during mitosis to ensure the phenotype of ...
    • Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 ... 
      Rojas, Adriana; Sepúlveda, Hugo; Henríquez, Berta; Aguilar, Rodrigo; Opazo, Tatiana; Nardocci, Gino; Bustos, Fernando; Lian, Jane B.; Stein, Janet L.; Stein, Gary S.; van Zundert, Brigitte; van Wijnen, Andre J.; Allende Connelly, Miguel; Montecino, Martín (Wiley, 2019)
      Expression of Runx2/p57 is a hallmark of the osteoblast-lineage identity. Although several regulators that control the expression of Runx2/p57 during osteoblast-lineage commitment have been identified, the epigenetic ...
    • Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors 
      Teplyuk, Nadiya M.; Galindo, Mario A.; Teplyuk, Viktor I.; Pratap, Jitesh; Young, Daniel W.; Lapointe, David; Javed, Amjad; Stein, Janet L.; Lian, Jane B.; Stein, Gary S.; Van Wijnen, Andre J. (2008)
      Runt-related transcription factor 2 (Runx2) controls lineage commitment, proliferation, and anabolic functions of osteoblasts as the subnuclear effector of multiple signaling axes (e.g. transforming growth factor-β/BMP-SMAD, ...