Browsing by Author "201-0010593"
Now showing items 1-20 of 57
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(Frontiers Media S.A., 2017)© 2017 Israel, Karahanian, Ezquer, Morales, Ezquer, Rivera-Meza, Herrera-Marschitz and Quintanilla. This review article addresses the biological factors that influence: (i) the acquisition of alcohol intake; (ii) the ...
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(Blackwell Publishing Ltd, 2019)© 2017 Society for the Study of Addiction Neuroinflammation has been reported to follow chronic ethanol intake and may perpetuate alcohol consumption. Present studies determined the effect of human mesenchymal stem cells ...
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(Elsevier Ltd, 2019)© 2018 Elsevier Ltd A number of pre-clinical studies have shown that brain-generated acetaldehyde, the first metabolite of ethanol, exerts reinforcing effects that promote the acquisition of ethanol intake, while chronic ...
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(2013)Background: Animals that have chronically consumed alcohol and are subsequently deprived of it markedly increase their intake above basal levels when access to alcohol is reinstated. Such an effect, termed the alcohol ...
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(Oxford Univ Press, 2015)
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(PERGAMON-ELSEVIER SCIENCE LTD, 2005-06-01)Hereditary hemochromatosis (HH) is a condition in which intestinal iron absorption is greatly elevated. Present treatment is weekly phlebotomy, affecting quality of life and leading to recurrent infections. The iron ...
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(Wiley-Blackwell, 2016)Background: A number of studies have shown that acetaldehyde synthesized in the brain is necessary to induce ethanol (EtOH) reinforcement in naive animals (acquisition phase). However, after chronic intake is achieved ...
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(Universidad de ChileCyberDocs, 2010)El trasplante de células troncales mesenquimáticas humanas (hMSC) derivadas de médula ósea ha mostrado ser terapéutico en patologías como osteogénesis imperfecta, reacción del injerto contra huésped e infarto agudo al ...
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(NATL INST ALCOHOL ABUSE ALCOHOLISM, 2006)Two lines of rats bred to differ in their voluntary alcohol consumption-the alcohol-abstaining UChA rats and the alcohol-drinking UChB rats-differ in how effectively toxic acetaldehyde is removed during alcohol metabolism. ...
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(Blackwell Publishing Ltd, 2018)© 2018 by the Research Society on Alcoholism Background: Life expectancy is greatly reduced in individuals presenting alcohol use disorders and chronic smoking. Literature studies suggest that common mechanisms may apply ...
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(Universidad de Chile, 2013-01)Estudios muestran que el efecto reforzante del alcohol estaría mediado por su metabolito primario, el acetaldehído. Esta molécula actuaría estimulando al sistema de recompensa, formado por neuronas dopaminérgicas que se ...
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(Universidad de Chile, 2013)El estudio de péptidos como moléculas terapéuticas ha generado gran interés en la industria farmacéutica debido a sus características de alta especificidad y actividad biológica y baja toxicidad. Igualmente, la exploración ...
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(2007)Lower tissue levels of dopamine and 5-hydroxytryptamine (5-HT) have been found in the nucleus accumbens of alcohol-naïve rats selectively bred to prefer ethanol than in rats bred to avoid it. These findings have led to the ...
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(WILEY-BLACKWELL, 2012)
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(2011)Background: While the molecular entity responsible for the rewarding effects of virtually all drugs of abuse is known, that for ethanol remains uncertain. Some lines of evidence suggest that the rewarding effects of alcohol ...
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(PERGAMON-ELSEVIER SCIENCE LTD, 2004-05)Chronic ethanol consumption leads to cell injury in virtually every tissue. Tumor necrosis factor-alpha (TNF-alpha) constitutes a major factor in the development of alcohol-induced liver injury. In alcohol-dependent subjects, ...
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(ELSEVIER, 2008-09-04)Several studies on the differences between ethanol-preferring versus non-preferring rat lines suggest an innate deficit in the mesolimbic dopaminergic system as an underlying factor for ethanol volition. Rats would try to ...
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(Elsevier Inc., 2014)© 2014 Elsevier Inc.The administration of disulfiram raises blood acetaldehyde levels when ethanol is ingested, leading to an aversion to alcohol. This study was aimed at assessing the effect of fenofibrate on voluntary ...
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(Wiley-Blackwell, 2015)This review analyzes literature that describes the behavioral effects of 2 metabolites of ethanol (EtOH): acetaldehyde and salsolinol (a condensation product of acetaldehyde and dopamine) generated in the brain. These ...
