Now showing items 1-20 of 30

    • Oróstica Arévalo, María Lorena; Rosas Chuñil, Carlos; Plaza Parrochia, Francisca; Astorga Leiva, Isis; Gabler Neale, Fernando; García Angulo, Víctor; Romero Osses, Carmen; Vega Blanco, María Margarita (Bentham Science, 2016)
      Background: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine/metabolic disorder characterized by hyperandrogenemia and in most cases, by hyper-insulinemia in addition to obesity. Besides ovarian dysfunction, ...
    • Johnson, M. Cecilia; Torres, Marisa; Alves, Alessandra; Bacallao, Ketty; Fuentes, Ariel; Vega Blanco, María Margarita; Boric Scarpa, María Angélica (2005)
      Background: Endometriosis is a common gynaecological disorder characterized by the presence of endometrial tissue outside of the uterus. The fragments in normal menstruation are composed of necrotic and living cells, which ...
    • Valladares, Macarena; Plaza Parrochia, Francisca; Lepez, Macarena; López Ponce, Daniela; Gabler Neale, Fernando; Gayan, Patricio; Selman, Alberto; Vega Blanco, María Margarita; Romero Osses, Carmen (Francisco Hernández, Editor, 2017)
      Introduction: Ovarian cancer presents a high angiogenesis (formation of new blood vessels) regulated by pro-angiogenic factors, mainly vascular endothelial growth factor (VEGF) and nerve growth factor (NGF). An association ...
    • Oróstica Arévalo, María Lorena; García, Paula; Vera, Carolina; García, Victor; Romero Osses, Carmen; Vega Blanco, María Margarita (Sage, 2018-07)
      Polycystic ovary syndrome (PCOS) affects not only ovarian functions but is also able to affect endometrium metabolism. Around 80% of women with PCOS are obese. High tumor necrosis factor (TNF)- production and low adiponectin ...
    • Oróstica Arévalo, María Lorena; García, Paula; Vera, Carolina; García, Víctor; Romero Osses, Carmen; Vega Blanco, María Margarita (SAGE Publications Inc., 2018)
      © The Author(s) 2017. Polycystic ovary syndrome (PCOS) affects not only ovarian functions but is also able to affect endometrium metabolism. Around 80% of women with PCOS are obese. High tumor necrosis factor (TNF)-α ...
    • Plaza Parrochia, Francisca; Romero Osses, Carmen; Valladares Boasi, Luis; Vega Blanco, María Margarita (Elsevier, 2017)
      Normal endometrial function requires of cell proliferation and differentiation; therefore, disturbances in these processes could lead to pathological entities such as hyperplasia and endometrial adenocarcinoma, where cell ...
    • Rosas Chuñil, Carlos; Oróstica Arévalo, María Lorena; Poblete, Cristian; Carvajal Gavilán, Rodrigo; Gabler Neale, Fernando; Romero Osses, Carmen; Lavandero González, Sergio; Vega Blanco, María Margarita (SAGE, 2016)
      Background: Women with polycystic ovary syndrome (PCOS) exhibit a low fertility by chronic hyperandrogenemia. Different evidence have shown that androgens could regulate the endoplasmic reticulum (ER) homeostasis and glucose ...
    • Vega Blanco, María Margarita; Devoto, Luigi; Navarro, Veronica; Castro, Olga; Kohen Skop, Paulina (1987)
      Slices of human corpora lutea (CL) obtained at varying stages of the luteal phase from 21 women were used to study the effect of hCG on progesterone (P4) production. Slices obtained from mid- and late CL incubated with 10 ...
    • Castro, Andrea; Castro, Olga; Troncoso, José Luis; Kohen Skop, Paulina; Simon, Carlos; Vega Blanco, María Margarita; Devoto, Luigi (Oxford University Press, 1998)
      Flow cytometry analysis of luteal cells revealed that an important proportion of these cells are leukocytes. The percentage of leukocytes was higher in the early (42 ± 4) and late (35 ± 3) luteal phases than in the mid-luteal ...
    • Croxatto, Horacio B.; Devoto, Luigi; Durand, Marta; Ezcurra, Enrique; Larrea, Fernando; Nagle, Carlos; Ortiz, María Elena; Vantman, David; Vega Blanco, María Margarita; Von Hertzen, Helena (Elsevier, 2001)
    • Garrido, Maritza P.; Vera, Carolina; Vega Blanco, María Margarita; Quest, Andrew F. G.; Romero Osses, Carmen (SAGE Publications Inc., 2018)
      © The Author(s), 2018. Background: Epithelial ovarian cancer (EOC) is characterized by exacerbated angiogenesis regulated by proangiogenic and growth factors. Nerve growth factor (NGF) is overexpressed in EOC where it ...
    • Garrido Palma, Maritza; Vega Blanco, María Margarita; Quest, Andrew F. G.; Romero Osses, Carmen (Spandidos Publications Ltd., 2017)
    • Garrido Palma, Maritza; Salvatierra, Renato; Valenzuela Valderrama, Manuel; Vallejos, Christopher; Bruneau, Nicole; Hernández, Andrea; Vega Blanco, María Margarita; Selman Abuchaibe, Alberto; Geoffery Quest, Andrew; Romero Osses, Carmen (MDPI, 2020)
      Epithelial ovarian cancer (EOC) is a lethal gynaecological neoplasm characterized by rapid growth and angiogenesis. Nerve growth factor (NGF) and its high affinity receptor tropomyosin receptor kinase A (TRKA) contribute ...
    • Plaza Parrochia, Francisca; Oróstica Arévalo, María Lorena; García, Paula; Vera, Carolina; Romero Osses, Carmen; Valladares Boasi, Luis; Vega Blanco, María Margarita (SAGE Publications Inc, 2017)
      Proliferation in endometria of women with polycystic ovarian syndrome (PCOS) is increased, similar to the biosynthesis of androstenediol (estrogenic metabolite). As previously shown, in human endometrial cells, androstenediol ...
    • Johnson, M. Cecilia; Castro, Andrea; Troncoso, José Luis; Vantman, David; Devoto, Luigi; Vega Blanco, María Margarita (1998)
      Objective: To determine the presence of angiotensin II and angiotensin II type-2 receptor subtype messenger RNA (mRNA) in human fallopian tube. Design: Frozen fallopian tubes were used for all studies. Setting: Procedures ...
    • Oróstica Arévalo, María Lorena; Poblete Rivas, Cristian; Romero Osses, Carmen; Vega Blanco, María Margarita (Springer, 2020)
      A pro-inflammatory environment is characteristic of obesity and polycystic ovary syndrome (PCOS). This environment through cytokines secretion negatively affects insulin action. Endometria from women with both conditions ...
    • Vega Blanco, María Margarita; Devoto, Luigi; Castro, Olga; Kohen Skop, Paulina (1994)
      To assess the role of estradiol (E2) upon progesterone (P4) synthesis, a well defined human midluteal cell system was used. A dose-dependent inhibition of P4 synthesis with and without hCG was induced by E2. In addition, ...
    • Vega Blanco, María Margarita; Devoto, Luigi; Castro, Olga; Kohen Skop, Paulina (1994)
      To assess the role of estradiol (E2) upon progesterone (P4) synthesis, a well defined human midluteal cell system was used. A dose-dependent inhibition of P4 synthesis with and without hCG was induced by E2. In addition, ...
    • Oróstica Arévalo, María Lorena; Astorga Leiva, Isis; Plaza Parrochia, Francisca; Vera Castillo, Carolina; García Angulo, Víctor; Carvajal Gavilán, Rodrigo; Gabler Neale, Fernando; Romero Osses, Carmen; Vega Blanco, María Margarita (Springer Nature, 2016)
      BACKGROUND/OBJECTIVES: A high percentage of women having polycystic ovarian syndrome (PCOS) exhibit hyperinsulinemia and obesity. Transforming necrosis factor-alpha (TNF-alpha) is an adipokine that increases in obesity and ...
    • Vega Blanco, María Margarita; Johnson, M. Cecilia; Díaz, Hugo A.; Urrutia, Luis R.; Troncoso, José L.; Devoto, Luigi (1998)
      To evaluate the effect of nitric oxide (NO·) in human corpus luteum (CL) function, we investigated the expression and the presence of NO· synthase (NOS) in the human CL and the action of NO· on the in vitro luteal ...