Browsing by Author "216b6031-e1dd-4aa2-a4df-8f2d80edbc50"

Now showing items 1-14 of 14

    • Activation of Chymotrypsin-Like Activity of the Proteasome during Ischemia Induces Myocardial Dysfunction and Death 
      Sánchez, Gina; Berrios, Daniela; Olmedo, Ivonne; Pezoa, Javier; Riquelme, Jaime A.; Montecinos, Luis; Pedrozo Cibils, Zully; Donoso Laurent, Paulina (Public Library Science, 2016)
      Inhibitors of the ubiquitin-proteasome system improve hemodynamic parameters and decrease the infarct size after ischemia reperfusion. The molecular basis of this protection is not fully understood since most available ...
    • Calpains and proteasomes mediate degradation of ryanodine receptors in a model of cardiac ischemic reperfusion 
      Pedrozo Cibils, Zully; Sánchez, G.; Torrealba, N.; Valenzuela, Rodrigo; Fernández, Carolina; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio; Donoso Laurent, Paulina (ELSEVIER SCIENCE BV, 2010-03)
      Type-2 ryanodine receptors (RyR2) - the calcium release channels of cardiac sarcoplasmic reticulum - have a central role in cardiac excitation-contraction coupling. In the heart, ischemia/reperfusion causes a rapid and ...
    • Down syndrome critical region 1 gene, Rcan1, helps maintain a more fused Mitochondrial Network 
      Parra Ortíz, María Valentina; Altamirano, Francisco; Hernández Fuentes, Carolina; Tong, Dan; Kyrychenko, Victoriia; Rotter, David; Pedrozo Cibils, Zully; Hill, Joseph A.; Eisner, Verónica; Lavandero González, Sergio; Schneider, Jay W.; Rothermel, Beverly A. (Lippincott Williams & Wilkins, 2018)
      Rationale: The regulator of calcineurin 1 (RCAN1) inhibits CN (calcineurin), a Ca2+-activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is located on chromosome 21 in proximity to the Down ...
    • Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury 
      Zepeda Iriarte, Ramiro; Kuzmicic, Jovan; Parra Ortiz, Valentina; Troncoso Cotal, Rodrigo; Pennanen, Christian; Riquelme, Jaime A.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Sánchez, Gina; Lavandero González, Sergio (Lippincott Williams and Wilkins, 2014)
      Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated by processes of fission and fusion. We hypothesized that the mitochondria fusion protein dynamin-related protein 1 (Drp1) inhibition, ...
    • Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: Possible role in ... 
      Sánchez, Gina; Escobar, Matías; Pedrozo Cibils, Zully; Macho Fisher, Pilar; Domenech Lira, Raúl; Härtel, Steffen; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (2008)
      Aim: Our objective was to investigate in cardiac muscle the contribution of NADPH oxidase to (a) ryanodine receptor-2 (RyR2) S-glutathionylation and (b) the preconditioning effects of exercise and tachycardia on infarct ...
    • Herp depletion protects from protein aggregation by up-regulating autophagy 
      Quiroga, Clara; Gatica, Damián; Paredes, Felipe; Bravo, Roberto; Troncoso, Rodrigo; Pedrozo Cibils, Zully; Rodríguez, Andrea E.; Toro, Barbra; Chiong Lay, Mario; Vicencio Bustamante, José Manuel; Hetz Flores, Claudio; Lavandero González, Sergio (Elsevier, 2013)
      Herp is an endoplasmic reticulum (ER) stress inducible protein that participates in the ER-associated protein degradation (ERAD) pathway. However, the contribution of Herp to other protein degradation pathways like autophagy ...
    • Herpud1 negatively regulates pathological cardiac hypertrophy by inducing IP3 receptor degradation 
      Torrealba, Natalia; Navarro Márquez, Mario F.; Vega Garrido, Valeria; Pedrozo Cibils, Zully; Romero, Diego; Eura, Yuka; Villalobos, Elisa; Carlos Roa, Juan; Chiong Lay, Mario; Kokame, Koichi; Lavandero González, Sergio (Nature Publishing Group, 2017)
      Cardiac hypertrophy is an adaptive response triggered by pathological stimuli. Regulation of the synthesis and the degradation of the Ca2+ channel inositol 1,4,5-trisphosphate receptor (IP3R) affects progression to cardiac ...
    • High fat diet induced obesity produces spontaneous ventricular arrhythmias and increases the activity of ... 
      Sánchez, Gina; Araneda, Felipe; Peña, Juan Pedro; Finkelstein, José Pablo; Riquelme, Jaime A.; Montecinos, Luis; Barrientos Briones, Genaro; Llanos Vidal, Paola; Pedrozo Cibils, Zully; Said, Matilde; Bull Simpfendorfer, Ricardo; Donoso Laurent, Paulina (MDPI, 2018)
      Ventricular arrhythmias are a common cause of sudden cardiac death, and their occurrence is higher in obese subjects. Abnormal gating of ryanodine receptors (RyR2), the calcium release channels of the sarcoplasmic reticulum, ...
    • Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction ... 
      Sánchez Vergara, Gina; Chalmers, Stefanie; Ahumada, Xavier; Montecinos, Luis; Olmedo Alegría, Ivonne Odette; Eisner, Verónica; Riveros, Ana; Kogan, Marcelo J.; Lavandero González, Sergio; Pedrozo Cibils, Zully; Donoso Laurent, Paulina (Public Library Science, 2020)
      The heart is critically dependent on mitochondrial respiration for energy supply. Ischemia decreases oxygen availability, with catastrophic consequences for cellular energy systems. After a few minutes of ischemia, the ...
    • Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes ... 
      Olmedo Alegría, Ivonne; Pino Tapia, Gonzalo; Riquelme Meléndez, Jaime; Aranguiz, Pablo; Díaz, Magda C.; López Crisosto, Camila; Lavandero González, Sergio; Donoso Laurent, Paulina; Pedrozo Cibils, Zully; Sánchez Vergara, Gina (Elsevier, 2020)
      Cardiomyocyte loss is the main cause of myocardial dysfunction following an ischemia-reperfusion (IR) injury. Mitochondrial dysfunction and altered mitochondrial network dynamics play central roles in cardiomyocyte death. ...
    • Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AK ... 
      Córdova, Andrés; Olmedo, Ivonne; Riquelme, J.; Barrientos, G.; Sánchez, G.; Gillette, Thomas G.; Lavandero González, Sergio; Chiong Lay, Mario; Donoso, P.; Pedrozo Cibils, Zully (Elsevier Science BV, 2018)
      The L-type calcium channel (LTCC) is an important determinant of cardiac contractility. Therefore, changes in LTCC activity or protein levels could be expected to affect cardiac function. Several studies describing LTCC ...
    • Miro1 as a novel regulator of hypertrophy in neonatal rat cardiomyocytes 
      Conejeros, Carolina; Parra Ortiz, Valentina; Sánchez Vergara, Gina; Pedrozo Cibils, Zully; Olmedo Alegría, Ivonne (Elsevier, 2020)
      Cardiac hypertrophy is an adaptive response to manage an excessive cardiac workload and maintain normal cardiac function. However, sustained hypertrophy leads to cardiomyopathy, cardiac failure, and death. Adrenergic ...
    • Oxidative stress and autophagy in cardiovascular homeostasis 
      Morales, Cyndi R.; Pedrozo Cibils, Zully; Lavandero González, Sergio; Hill, Joseph A. (Mary Ann Liebert, 2014)
      Significance: Autophagy is an evolutionarily ancient process of intracellular protein and organelle recycling required to maintain cellular homeostasis in the face of a wide variety of stresses. Dysregulation of reactive ...
    • Polycystin-2-dependent control of cardiomyocyte autophagy 
      Criollo Céspedes, Alfredo; Altamirano, Francisco; Pedrozo Cibils, Zully; Schiattarella, Gabriele G.; Li, Dan L.; Rivera‐Mejias, Pablo; Sotomayor Flores, Cristian; Parra, Valentina; Villalobos, Elisa; Battiprolu, Pavan K.; Jiang, Nan; May, Herman I.; Morselli, Eugenia; Somlo, Stefan; Smedt, Humbert de; Gillette, Thomas G.; Lavandero González, Sergio; Hill, Joseph A. (Elsevier, 2018-05)
      Aims: Considerable evidence points to critical roles of intracellular Ca2+ homeostasis in the modulation and control of autophagic activity. Yet, underlying molecular mechanisms remain unknown. Mutations in the gene (pkd2) ...