Now showing items 1-15 of 15

    • Sánchez, Gina; Berrios, Daniela; Olmedo, Ivonne; Pezoa, Javier; Riquelme, Jaime A.; Montecinos, Luis; Pedrozo Cibils, Zully; Donoso Laurent, Paulina (Public Library Science, 2016)
      Inhibitors of the ubiquitin-proteasome system improve hemodynamic parameters and decrease the infarct size after ischemia reperfusion. The molecular basis of this protection is not fully understood since most available ...
    • Pedrozo Cibils, Zully; Sánchez, G.; Torrealba, N.; Valenzuela, Rodrigo; Fernández, Carolina; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio; Donoso Laurent, Paulina (ELSEVIER SCIENCE BV, 2010-03)
      Type-2 ryanodine receptors (RyR2) - the calcium release channels of cardiac sarcoplasmic reticulum - have a central role in cardiac excitation-contraction coupling. In the heart, ischemia/reperfusion causes a rapid and ...
    • Parra Ortíz, María Valentina; Altamirano, Francisco; Hernández Fuentes, Carolina; Tong, Dan; Kyrychenko, Victoriia; Rotter, David; Pedrozo Cibils, Zully; Hill, Joseph A.; Eisner, Verónica; Lavandero González, Sergio; Schneider, Jay W.; Rothermel, Beverly A. (Lippincott Williams & Wilkins, 2018)
      Rationale: The regulator of calcineurin 1 (RCAN1) inhibits CN (calcineurin), a Ca2+-activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is located on chromosome 21 in proximity to the Down ...
    • Zepeda Iriarte, Ramiro; Kuzmicic, Jovan; Parra Ortiz, Valentina; Troncoso Cotal, Rodrigo; Pennanen, Christian; Riquelme, Jaime A.; Pedrozo Cibils, Zully; Chiong Lay, Mario; Sánchez, Gina; Lavandero González, Sergio (Lippincott Williams and Wilkins, 2014)
      Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated by processes of fission and fusion. We hypothesized that the mitochondria fusion protein dynamin-related protein 1 (Drp1) inhibition, ...
    • Sánchez, Gina; Escobar, Matías; Pedrozo Cibils, Zully; Macho Fisher, Pilar; Domenech Lira, Raúl; Härtel, Steffen; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (2008)
      Aim: Our objective was to investigate in cardiac muscle the contribution of NADPH oxidase to (a) ryanodine receptor-2 (RyR2) S-glutathionylation and (b) the preconditioning effects of exercise and tachycardia on infarct ...
    • Quiroga, Clara; Gatica, Damián; Paredes, Felipe; Bravo, Roberto; Troncoso, Rodrigo; Pedrozo Cibils, Zully; Rodríguez, Andrea E.; Toro, Barbra; Chiong Lay, Mario; Vicencio Bustamante, José Manuel; Hetz Flores, Claudio; Lavandero González, Sergio (Elsevier, 2013)
      Herp is an endoplasmic reticulum (ER) stress inducible protein that participates in the ER-associated protein degradation (ERAD) pathway. However, the contribution of Herp to other protein degradation pathways like autophagy ...
    • Torrealba, Natalia; Navarro Márquez, Mario F.; Vega Garrido, Valeria; Pedrozo Cibils, Zully; Romero, Diego; Eura, Yuka; Villalobos, Elisa; Carlos Roa, Juan; Chiong Lay, Mario; Kokame, Koichi; Lavandero González, Sergio (Nature Publishing Group, 2017)
      Cardiac hypertrophy is an adaptive response triggered by pathological stimuli. Regulation of the synthesis and the degradation of the Ca2+ channel inositol 1,4,5-trisphosphate receptor (IP3R) affects progression to cardiac ...
    • Sánchez, Gina; Araneda, Felipe; Peña, Juan Pedro; Finkelstein, José Pablo; Riquelme, Jaime A.; Montecinos, Luis; Barrientos Briones, Genaro; Llanos Vidal, Paola; Pedrozo Cibils, Zully; Said, Matilde; Bull Simpfendorfer, Ricardo; Donoso Laurent, Paulina (MDPI, 2018)
      Ventricular arrhythmias are a common cause of sudden cardiac death, and their occurrence is higher in obese subjects. Abnormal gating of ryanodine receptors (RyR2), the calcium release channels of the sarcoplasmic reticulum, ...
    • Sánchez, Gina; Loyola Araneda, Felipe; Peña, Juan Pedro; Finkelstein Muñoz, José Pablo; Riquelme, Jaime A.; Montecinos, Luis; Barrientos, Genaro; Llanos Vidal, Paola; Pedrozo Cibils, Zully; Said, Matilde; Bull, Ricardo; Donoso Laurent, Paulina (MDPI AG, 2018)
      © 2018 by the authors. Licensee MDPI, Basel, Switzerland. Ventricular arrhythmias are a common cause of sudden cardiac death, and their occurrence is higher in obese subjects. Abnormal gating of ryanodine receptors (RyR2), ...
    • Sánchez Vergara, Gina; Chalmers, Stefanie; Ahumada, Xavier; Montecinos, Luis; Olmedo Alegría, Ivonne Odette; Eisner, Verónica; Riveros, Ana; Kogan, Marcelo J.; Lavandero González, Sergio; Pedrozo Cibils, Zully; Donoso Laurent, Paulina (Public Library Science, 2020)
      The heart is critically dependent on mitochondrial respiration for energy supply. Ischemia decreases oxygen availability, with catastrophic consequences for cellular energy systems. After a few minutes of ischemia, the ...
    • Olmedo Alegría, Ivonne; Pino Tapia, Gonzalo; Riquelme Meléndez, Jaime; Aranguiz, Pablo; Díaz, Magda C.; López Crisosto, Camila; Lavandero González, Sergio; Donoso Laurent, Paulina; Pedrozo Cibils, Zully; Sánchez Vergara, Gina (Elsevier, 2020)
      Cardiomyocyte loss is the main cause of myocardial dysfunction following an ischemia-reperfusion (IR) injury. Mitochondrial dysfunction and altered mitochondrial network dynamics play central roles in cardiomyocyte death. ...
    • Córdova, Andrés; Olmedo, Ivonne; Riquelme, J.; Barrientos, G.; Sánchez, G.; Gillette, Thomas G.; Lavandero González, Sergio; Chiong Lay, Mario; Donoso, P.; Pedrozo Cibils, Zully (Elsevier Science BV, 2018)
      The L-type calcium channel (LTCC) is an important determinant of cardiac contractility. Therefore, changes in LTCC activity or protein levels could be expected to affect cardiac function. Several studies describing LTCC ...
    • Conejeros, Carolina; Parra Ortiz, Valentina; Sánchez Vergara, Gina; Pedrozo Cibils, Zully; Olmedo Alegría, Ivonne (Elsevier, 2020)
      Cardiac hypertrophy is an adaptive response to manage an excessive cardiac workload and maintain normal cardiac function. However, sustained hypertrophy leads to cardiomyopathy, cardiac failure, and death. Adrenergic ...
    • Morales, Cyndi R.; Pedrozo Cibils, Zully; Lavandero González, Sergio; Hill, Joseph A. (Mary Ann Liebert, 2014)
      Significance: Autophagy is an evolutionarily ancient process of intracellular protein and organelle recycling required to maintain cellular homeostasis in the face of a wide variety of stresses. Dysregulation of reactive ...
    • Criollo Céspedes, Alfredo; Altamirano, Francisco; Pedrozo Cibils, Zully; Schiattarella, Gabriele G.; Li, Dan L.; Rivera‐Mejias, Pablo; Sotomayor Flores, Cristian; Parra, Valentina; Villalobos, Elisa; Battiprolu, Pavan K.; Jiang, Nan; May, Herman I.; Morselli, Eugenia; Somlo, Stefan; Smedt, Humbert de; Gillette, Thomas G.; Lavandero González, Sergio; Hill, Joseph A. (Elsevier, 2018-05)
      Aims: Considerable evidence points to critical roles of intracellular Ca2+ homeostasis in the modulation and control of autophagic activity. Yet, underlying molecular mechanisms remain unknown. Mutations in the gene (pkd2) ...