Browsing by Author "21860954-53dd-4eff-92bd-8e1079cad27f"

Now showing items 1-7 of 7

    • Ca(v)1.2 Activity and Downstream Signaling Pathways in the Hippocampus of An Animal Model of Depression 
      Moreno, Cristian; Hermosilla, Tamara; Hardy, Paulina; Aballai, Víctor; Rojas, Patricio; Varela Lekanda, Diego (MDPI, 2020)
      Functional and morphological modifications in the brain caused by major mood disorders involve many brain areas, including the hippocampus, leading to cognitive and mood alterations. Ca(v)1.2 channel expression has been ...
    • Calcium-dependent inactivation controls cardiac L-type Ca2+ currents under β-adrenergic stimulation 
      Morales, Danna; Hermosilla, Tamara; Varela, Diego (NLM (Medline), 2019)
      The activity of L-type calcium channels is associated with the duration of the plateau phase of the cardiac action potential (AP) and it is controlled by voltage- and calcium-dependent inactivation (VDI and CDI, respectively). ...
    • Cavβ2 transcription start site variants modulate calcium handling in newborn rat cardiomyocytes 
      Moreno, Cristian; Hermosilla, Tamara; Morales, Danna; Encina, Matías; Torres-Díaz, Leandro; Díaz, Pablo; Sarmiento, Daniela; Simon, Felipe; Varela, Diego (Springer Verlag, 2015)
      © 2015, Springer-Verlag Berlin Heidelberg.In the heart, the main pathway for calcium influx is mediated by L-type calcium channels, a multi-subunit complex composed of the pore-forming subunit CaV1.2 and the auxiliary ...
    • Ion channel formation by Alzheimer's disease amyloid beta-peptide (A beta 40) in unilamellar liposomes is ... 
      Alarcón, Juan Marcos; Brito Jara, Julio; Hermosilla, Tamara; Atwater Ransom, Illani; Mears, David; Rojas, Eduardo (ELSEVIER, 2006-01)
      Incorporation of Alzheimer's disease amyloid beta-proteins (A beta Ps) across natural and artificial bilayer membranes leads to the formation of cation-selective channels. To study the peptide-membrane interactions involved ...
    • L-type calcium channel β subunit modulates angiotensin II responses in cardiomyocytes 
      Hermosilla, Tamara; Moreno, Cristian; Itfinca, Mircea; Altier, Christophe; Armisen Yáñez, Ricardo; Stutzin Schottlander, Andrés; Zamponi, Gerald W.; Varela, Diego (Taylor and Francis Inc., 2011)
      Angiotensin II regulation of L-type calcium currents in cardiac muscle is controversial and the underlying signaling events are not completely understood. Moreover, the possible role of auxiliary subunit composition of the ...
    • Prolonged AT(1)R activation induces Ca(V)1.2 channel internalization in rat cardiomyocytes 
      Hermosilla, Tamara; Encina, Matías; Morales, Danna; Moreno, Cristian; Conejeros, Carolina; Alfaro Valdés, Hilda M.; Lagos Meza, Felipe; Simon, Felipe; Altier, Christophe; Varela, Diego (Nature Publishing Group, 2017)
      The cardiac L-type calcium channel is a multi-subunit complex that requires co-assembling of the pore-forming subunit Ca(V)1.2 with auxiliary subunits Ca-V alpha 2 delta and Ca-V beta. Its traffic has been shown to be ...
    • Recognition of an immunogenetically selected Trypanosoma cruzi antigen by seropositive chagasic human sera 
      Aguillón Gutiérrez, Juan Carlos; Harris, Robert; Molina, María Carmen; Colombo, Alicia; Cortés, Claudio; Hermosilla, Tamara; Carreño, Paz; Örn, Anders; Ferreira, Arturo (1997)
      If the H-2 congenic mouse strains A.SW (H-2(s)) and A.CA (H-2(f)), are infected with Trypanosoma cruzi, a 45 kDa protein (Tc45), present in cultured epimastigotes and blood trypomastigotes, is recognized only by the A.SW ...