Browsing by Author "2539ef45-8f82-4eec-b6fd-94625904e7ff"
Now showing items 1-20 of 54
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Acute perinatal asphyxia impairs non-spatial memory and alters motor coordination in adult male rats (SPRINGER, 2008-03)A large body of clinical evidence suggests a possible association between perinatal asphyxia and the onset of early, as well as long-term, neurological and psychiatric disorders including cognitive deWcits. The ...
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(Elsevier, 2013-06)Current pharmacological therapies for depression, including selective serotonin reuptake inhibitors (SSRI), are far from ideal. The cannabinoid system has been implicated in control of mood and neural processing of emotional ...
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(2006)Background: Corticosterone reduction produced by adrenalectomy (ADX) induces apoptosis in dentate gyrus (DG) of the hippocampus, an effect related to an increase in the expression of the pro-apoptotic gene bax. However it ...
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(2013)Background: Animals that have chronically consumed alcohol and are subsequently deprived of it markedly increase their intake above basal levels when access to alcohol is reinstated. Such an effect, termed the alcohol ...
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(BIOMED Central Ltd., 2017)Background: Neuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging alpha(V)beta(3) Integrin and Syndecan-4. Primary astrocytes express ...
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(Oxford Univ Press, 2015)
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(Wiley-Blackwell, 2016)Background: A number of studies have shown that acetaldehyde synthesized in the brain is necessary to induce ethanol (EtOH) reinforcement in naive animals (acquisition phase). However, after chronic intake is achieved ...
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(ELSEVIER SCI IRELAND LTD, 2002-10-04)It has previously been shown that adrenalectomy (ADX) produces apoptosis in the granule cell of the dentate gyrus (DG), and that this effect is prevented by corticosterone replacement. Thus, we have investigated how this ...
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(2007)Lower tissue levels of dopamine and 5-hydroxytryptamine (5-HT) have been found in the nucleus accumbens of alcohol-naïve rats selectively bred to prefer ethanol than in rats bred to avoid it. These findings have led to the ...
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(Elsevier, 2016)Perinatal asphyxia (PA) is associated with long-term neuronal damage and cognitive deficits in adulthood, such as learning and memory disabilities. After PA, specific brain regions are compromised, including neocortex, ...
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(PERGAMON-ELSEVIER SCIENCE, 2005)The present report summarizes studies combining an in vivo and in vitro approach, where asphyxia is induced in vivo at delivery time of Wistar rats, and the long term effects on hippocampus neurocircultry are investigated ...
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(2011)Background: While the molecular entity responsible for the rewarding effects of virtually all drugs of abuse is known, that for ethanol remains uncertain. Some lines of evidence suggest that the rewarding effects of alcohol ...
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(ELSEVIER, 2008-09-04)Several studies on the differences between ethanol-preferring versus non-preferring rat lines suggest an innate deficit in the mesolimbic dopaminergic system as an underlying factor for ethanol volition. Rats would try to ...
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(2007)The detailed anatomy of the monoamine pathways of the rat, first described by the students of Nils-Åke Hillarp in Sweden, provided the basis for a neurocircuitry targeted pharmacology, leading to important therapeutic ...
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(Wiley-Blackwell, 2015)This review analyzes literature that describes the behavioral effects of 2 metabolites of ethanol (EtOH): acetaldehyde and salsolinol (a condensation product of acetaldehyde and dopamine) generated in the brain. These ...
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(2012)Oxygen interruption leads to death when reoxygenation is not promptly re-established. Re-oxygenation triggers a cascade of biochemical events for restoring function at the cost of improper homeostasis. The effects observed ...
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(Dr. Dietrich Steinkopff Verlag GmbH and Co. KG, 2014)We investigated gene expression pattern obtained from microarray data of 10 schizophrenia patients and 10 control subjects. Brain tissue samples were obtained postmortem; thus, the different ages of the patients at death ...
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(FRONTIERS RESEARCH FOUNDATION, 2013-07-08)Ethanol is metabolized into acetaldehyde mainly by the action of alcohol dehydrogenase in the liver, while mainly by the action of catalase in the brain. Aldehyde dehydrogenase-2 metabolizes acetaldehyde into acetate in ...
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(2002)Intracerebral manganese administration together with the DT-diaphorase inhibitor dicoumarol (Mn3+ 40 nmol+-dicoumarol 2 nmol; in 4 μl) into the left medial forebrain bundle (MFB) produced a behavioural pattern characterised ...
