Browsing by Author "2880137f-7162-4372-8766-c25725b60058"

Now showing items 1-4 of 4

    • Genetic variants in FGFR2 and MAP3K1 are associated with the risk of familial and early-onset breast cancer ... 
      Jara Sosa, Lilian; González Hormazábal, Patricio; Cerceño, Kerube; Di Capua, Gabriella A.; Reyes, José M.; Blanco Castillo, Rafael; Bravo, Teresa; Peralta Musre, Octavio; Gómez, Fernando; Waugh, Enrique; Margarit, Sonia; Gladys, Ibáñez; Romero Osses, Carmen; Pakomio, Janara; Roizen, Gigia (SPRINGER, 2012-12-07)
      Genome-Wide Association Studies have identified several loci associated with breast cancer (BC) in populations of different ethnic origins. One of the strongest associations was found in the FGFR2 gene, and MAP3K1 has ...
    • RAD51 135G>C polymorphism and risk of familial breast cancer in a South American population 
      Jara, Lilian; Acevedo, Monica L.; Blanco, Rafael; Castro, Victor G.; Bravo, Teresa; Gómez, Fernando; Waugh, Enrique; Peralta, Octavio; Cabrera, Elsa; Reyes, José M.; Ampuero Llanos, Sandra; González Hormazábal, Patricio (2007)
      Several studies have reported that mutations in genes involved in maintenance of genome integrity may be responsible for increased cancer risk. Human RAD51, known to function in DNA repair, interacts with a number of ...
    • The BARD1 Cys557Ser variant and risk of familial breast cancer in a South-American population 
      González Hormazábal, Patricio; Reyes, Jose M.; Blanco, Rafael; Bravo, Teresa; Carrera, Ignacio; Peralta, Octavio; Gomez, Fernando; Waugh, Enrique; Margarit, Sonia; Ibañez, Gladys; Santos, José Luis; Jara, Lilian (2012)
      Since the discovery of the BRCA1 and BRCA2 genes, much work has been carried out to identify further breast cancer (BC) susceptibility genes. BARD1 (BRCA1-associated ring domain) was originally identified as a BRCA1-interacting ...
    • Variants in DNA double-strand break repair genes and risk of familial breast cancer in a South American population 
      Jara, Lilian; Dubois, Karen; Gaete, Daniel; De Mayo, Tomas; Ratkevicius, Nikalai; Bravo, Teresa; Margarit, Sonia; Blanco, Rafael; Gómez, Fernando; Waugh, Enrique; Peralta, Octavio; Reyes, Jose M.; Ibáñez, Gladys; González Hormazábal, Patricio (Springer New York, 2010)
      The double-strand break (DSB) DNA repair pathway has been implicated in breast cancer (BC). RAD51 and its paralogs XRCC3 and RAD51D play an important role in the repair of DSB through homologous recombination (HR). Some ...