Browsing by Author "28e98517-e77b-4354-b9ce-16a246cdeb20"

Now showing items 1-6 of 6

    • 4-Methylthioamphetamine Increases Dopamine in the Rat Striatum and has Rewarding Effects In Vivo 
      Sotomayor Zárate, Ramón; Quiroz, Gabriel; Araya, Katherine A.; Abarca, Jorge; Ibáñez, María R.; Montecinos, Alejandro; Guajardo, Carlos; Núñez, Gabriel; Fierro, Angélica; Moya, Pablo R.; Iturriaga-Vásquez, Patricio; Gómez-Molina, Cristóbal; Gysling, Katia; Reyes Parada, Miguel (2012)
      4-Methylthioamphetamine (MTA) is a phenylisopropylamine derivative whose use has been associated with severe intoxications. MTA is usually regarded as a selective serotonin-releasing agent. Nevertheless, previous data have ...
    • Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors, decreases ethanol ... 
      Quiroz, Gabriel; Guerra-Díaz, Nicolás; Iturriaga-Vásquez, Patricio; Rivera Meza, Mario; Quintanilla González, María Elena; Sotomayor Zárate, Ramón (Elsevier, 2018-09)
      Alcohol abuse is a worldwide health problem with high economic costs to health systems. Emerging evidence suggests that modulation of brain nicotinic acetylcholine receptors (nAChRs) may be a therapeutic target for alcohol ...
    • Nicotinic antagonist UFR2709 inhibits nicotine reward and decreases anxiety in zebrafish 
      Viscarra, Franco; González Gutiérrez, Juan; Esparza, Erica; Figueroa, Carla; Paillali, Pablo; Hödar Salazar, Martín; Céspedes, Camilo; Quiroz, Gabriel; Sotomayor Zárate, Ramón; Reyes Parada, Miguel; Bermúdez, Isabel; Iturriaga-Vásquez, Patricio (MDPI, 2020)
      Zebrafish is becoming a popular animal model in neuropharmacology and drug discovery, mainly due to its ease of handling and low costs involved in maintenance and experimental work. This animal displays a series of complex ...
    • Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core 
      Méndez-Rojas, Claudio; Quiroz, Gabriel; Faúndez, Mario; Gallardo Garrido, Carlos Andrés; Pessoa Mahana, Carlos David; Chung, Hery; Gallardo Toledo, Eduardo; Saitz Barría, Claudio; Araya Maturana, Ramiro; Kogan Bocian, Marcelo; Zúñiga López, María C.; Iturriaga-Vásquez, Patricio; (Wiley-VCH Verlag, 2018)
      © 2018 Deutsche Pharmazeutische Gesellschaft With the purpose of expanding the structural variety of chemical compounds available as pharmacological tools for the treatment of Alzheimer's disease, we synthesized and evaluated ...
    • Synthesis and Docking of Novel 3-Indolylpropyl Derivatives as New Polypharmacological Agents Displaying ... 
      Pessoa Mahana, Hernán; Silva Matus, Paul Eduardo; Pessoa Mahana, Carlos David; Chung, Hery; Iturriaga-Vásquez, Patricio; Quiroz, Gabriel; Möller-Acuña, Patricia; Zapata Torres, Gerald; Saitz Barría, Claudio; Araya Maturana, Ramiro; Reyes Parada, Miguel (Wiley, 2017)
      A series of novel 3-indolylpropyl derivatives was synthesized and evaluated for their binding affinities at the serotonin-1A receptor subtype (5-HT1AR) and the 5-HT transporter (SERT). Compounds 11b and 14b exhibited the ...
    • Synthesis, Docking, 3-D-Qsar, and Biological Assays of Novel Indole Derivatives Targeting Serotonin ... 
      Cerda Cavieres, Christopher David; Quiroz, Gabriel; Iturriaga-Vásquez, Patricio; Rodríguez Lavado, Julio; Alarcón Espósito, Jazmín; Saitz Barría, Claudio; Pessoa Mahana, Carlos D.; Chung, Hery; Araya Maturana, Ramiro; Mella Raipán, Jaime A.; Cabezas, David; Ojeda Gómez, Claudia; Reyes Parada, Miguel; Pessoa Mahana, Hernán (MDPI, 2020)
      A series of 27 compounds of general structure 2,3-dihydro-benzo[1,4]oxazin-4-yl)-2-{4-[3-(1H-3indolyl)-propyl]-1-piperazinyl}-ethanamides, Series I: 7(a-o) and (2-{4-[3-(1H-3-indolyl)-propyl]-1-piperazinyl}-acetylamine)- ...