Now showing items 1-20 of 25

    • Lemus Cortés, Carmen; Palma, Karina; Jara, Jorge; Cramer, Teresa; Härtel, Steffen; Concha Nordemann, Miguel (Elsevier, 2017-07)
    • Horta, Fabrizzio; Madariaga, Marcia; García, Alejandra; Härtel, Steffen; Smith Garcés, Rosita (SOC MEDICA SANTIAGO, 2011-03)
      Background: There is an association between aging and an increased number of sperms with alterations in nuclear DNA. Aim: To study the association between age and fragmentation of sperm DNA. Material and Methods: Sixty two ...
    • Chang, Violeta; Heutte, Laurent; Petitjean, Caroline; Härtel, Steffen; Hitschfeld, Nancy (Elsevier, 2017)
      Background and objective: Infertility is a problem that affects up to 15% of couples worldwide with emotional and physiological implications and semen analysis is the first step in the evaluation of an infertile couple. ...
    • Liddle, Pablo; Lafon-Hughes, Laura; Di Tomaso, María Vittoria; Reyes-Ábalos, Ana Laura; Jara, Jorge; Cerda, Mauricio; Härtel, Steffen; Folle, Gustavo A. (Kluwer Academic Publishers, 2014)
      © 2014, Springer Science+Business Media Dordrecht.Exposure to DNA damaging agents triggers phosphorylation of histone variant H2AX (generating γH2AX) in large chromatin regions flanking DNA lesions, allowing their ...
    • Posada Duque, Rafael; Ramírez, Omar A.; Härtel, Steffen; Inestrosa, Nibaldo C.; Bodaleo, Felipe; González Billault, Christian; Kirkwood, Alfredo; Cardona Gómez, Gloria (Birkhauser Verlag AG, 2017)
      © 2016, Springer International Publishing. CDK5 is a serine/threonine kinase that is involved in the normal function of the adult brain and plays a role in neurotransmission and synaptic plasticity. However, its over-regulation ...
    • Bahamondes, Verónica; Albornoz, Amelina; Aguilera, Sergio; Alliende, Cecilia; Molina, Claudio; Castro, Isabel; Urzúa, Ulises; Quest, Andrew F. G.; Barrera, María José; González, Sergio; Sánchez, Marianela; Härtel, Steffen; Hermoso Ramello, Marcela; Leyton, Cecilia; González, Ma (2011)
      Objective Oral and ocular dryness are frequent and serious symptoms of Sjögren's syndrome (SS) that reflect problems in secretion due to glandular dysfunction. Exocytosis, an important process in the secretory pathway, ...
    • Capurro, Daniel; Echeverry, Aisen; Figueroa, Rosa; Guiñez, Sergio; Taramasco, Carla; Galindo, César; Avendaño, Angélica; García, Alejandra; Hartel, Steffen (IOS, 2017)
      Despite the continuous technical advancements around health information standards, a critical component to their widespread adoption involves political agreement between a diverse set of stakeholders. Countries that ...
    • Ramírez, Omar A.; Vidal, René L.; Tello, Judith A.; Vargas, Karina J.; Kindler, Stefan; Härtel, Steffen; Couve, Andrés (2009)
      Understanding the mechanisms that control synaptic efficacy through the availability of neurotransmitter receptors depends on uncovering their specific intracellular trafficking routes. γ-Aminobutyric acid type B (GABAB) ...
    • Ahumada Galleguillos, Patricio; Lemus, Carmen G.; Díaz, Eugenia; Osorio-Reich, María; Härtel, Steffen; Concha Nordemann, Miguel (Springer Verlag, 2017)
      © 2016, Springer-Verlag Berlin Heidelberg.Brain asymmetry is a conserved feature in vertebrates. The dorsal diencephalic habenular complex shows conspicuous structural and functional asymmetries in a wide range of species, ...
    • Frigerio, Sofía; Da Costa, Valeria; Costa, Monique; Festari, María Florencia; Landeira, Mercedes; Rodríguez Zraquia, Santiago A.; Härtel Gründler, Steffen; Toledo Hernández, Jorge; Freire, Toledo (Frontiers Media, 2020)
      Eosinophils are granulocytes that participate in the defense against helminth parasites and in hypersensitivity reactions. More recently, eosinophils were shown to have other immunomodulatory functions, such as tissue ...
    • Sigle, Stefan; Barriga, Pilar; Correa Fernández, Francisco Javier; Juhra, Christian; Härtel, Steffen; Fegeler, Christian (JMIR, 2020)
      Background: Medication is the most common intervention in health care, and the number of online consumer information systems within the pharmaceutical sector is increasing. However, online consumer information systems can ...
    • Sánchez, Gina; Escobar, Matías; Pedrozo Cibils, Zully; Macho Fisher, Pilar; Domenech Lira, Raúl; Härtel, Steffen; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (2008)
      Aim: Our objective was to investigate in cardiac muscle the contribution of NADPH oxidase to (a) ryanodine receptor-2 (RyR2) S-glutathionylation and (b) the preconditioning effects of exercise and tachycardia on infarct ...
    • Reig Cardarella, Germán; Cerda Villablanca, Mauricio; Sepúlveda Salazar, Néstor; Flores Campo, Daniela; Castañeda, Víctor; Masazumi, Tada; Härtel, Steffen; Concha Nordemann, Miguel (Nature Publishing Group, 2017-06-05)
      The spreading of mesenchymal-like cell layers is critical for embryo morphogenesis and tissue repair, yet we know little of this process in vivo. Here we take advantage of unique developmental features of the non-conventional ...
    • Chang, Violeta; García, Alejandra; Hitschfeld Kahler, Nancy; Härtel, Steffen (Elsevier, 2017)
      Background and Objective: Published algorithms for classification of human sperm heads are based on relatively small image databases that are not open to the public, and thus no direct comparison is available for competing ...
    • Ampuero, Estibaliz; Jury, Nur; Härtel, Steffen; Marzolo, María Paz; van Zundert, Brigitte (Wiley-Liss Inc., 2017)
      © 2016 Wiley Periodicals, Inc. Reelin, an extracellular glycoprotein secreted in embryonic and adult brain, participates in neuronal migration and neuronal plasticity. Extensive evidence shows that reelin via activation ...
    • Palma González, Karina; Meynard Moreno, Margarita; Cornejo, Valeria; Cerda Villablanca, Mauricio; Jara, Jorge; Härtel, Steffen; Concha Nordemann, Miguel (Elsevier, 2017-07)
    • Vidal, René L.; Ramírez, Omar A.; Sandoval, Lisette; Koenig Robert, Roger; Härtel, Steffen; Couve Correa, Andrés (2007)
      The cytoskeleton and cytoskeletal motors play a fundamental role in neurotransmitter receptor trafficking, but proteins that link GABAB receptors (GABABRs) to the cytoskeleton have not been described. We recently identified ...
    • Cuevas, Evelyn; Courdurier, Matías; Osses Alvarado, Axel; Castañeda Zeman, Víctor; Palacios, Benjamín; Härtel, Steffen (IOP Publishing, 2020)
      We study an inverse problem for light sheet fluorescence microscopy (LSFM), where the density of fluorescent molecules needs to be reconstructed. Our first step is to present a mathematical model to describe the measurements ...
    • Tortosa, Elena; Montenegro Venegas, Carolina; Benoist, Marion; Härtel, Steffen; González Billault, Christian; Esteban, Jose A.; Avila, Jesús (2011)
      Microtubule-associated protein 1B (MAP1B) is prominently expressed during early stages of neuronal development, and it has been implicated in axonal growth and guidance. MAP1B expression is also found in the adult brain ...
    • Espinosa, Alejandra; García, Alejandra; Härtel, Steffen; Hidalgo Tapia, María Cecilia; Jaimovich Pérez, Enrique (2009)
      Skeletal muscle is one of the main physiological targets of insulin, a hormone that triggers a complex signaling cascade and that enhances the production of reactive oxygen species (ROS) in different cell types. ROS, ...