Browsing by Author "2f230ae3-cbdf-4add-90c3-38dcf1588145"

Now showing items 1-8 of 8

    • In vitro and in vivo antitrypanosomatid activity of 5-nitroindazoles 
      Boiani, Lucia; Gerpe, Alejandra; Arán, Vicente; Torres de Ortiz, Susana; Serna, Elva; Vera de Bilbao, Ninfa; Sanabria, Luis; Yaluff, Gloria; Nakayama, Héctor; Rojas de Arias, Antonieta; Maya Arango, Juan; Morello, J.; Cerecetto, Hugo; González, Mercedes (2009)
      Previously, we have identified a series of 5-nitroindazoles with good antiprotozoal activities, against Trypanosoma cruzi epimastigotes and Trichomonas vaginalis. Most of them have shown very low unspecific toxicity on ...
    • Nitrones: a potential new alternative as therapeutic agents 
      Barriga González, Germán Eduardo; Aliaga, Carolina; Olea Azar, Claudio; Zúniga López, María C.; González, Mercedes; Cerecetto, Hugo (Bentham Science Publishers Ltd., 2017)
      Background: Nowadays, nitrones are the most used spin traps to characterize free radicals in biological systems due to the versatility and variety depending on the types of radicals to study and that the half-lives of the ...
    • Platinum-based complexes of bioactive 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-Trypanosoma ... 
      Vieites, Marisol; Otero, Lucía; Santos, Diego; Olea Azar, Claudio; Norambuena, Ester; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Kemmerling Weis, Ulrike; Morello Casté, Antonio; Maya Arango, Juan; Gambino, Dinorah (2009)
      Eight new platinum(II) complexes with 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-trypanosomal activity were synthesized, characterized and in vitro evaluated. Most of the complexes showed IC50 values in the ...
    • Potent 5-nitrofuran derivatives inhibitors of Trypanosoma cruzi growth: Electrochemical, spectroscopic and ... 
      Aravena, María C.; Olea Azar, Claudio; Cerecetto, Hugo; González, Mercedes; Maya Arango, Juan; Rodríguez Becerra, Jorge (2011)
      Cyclic voltammetry and electron spin resonance techniques were used in the investigation of several potential antiprotozoal containing thiosemicarbazone and carbamate nitrofurans. In the electrochemical behaviour, a ...
    • Structural modifications on the phenazine N,N′-dioxide-scaffold looking for new selective hypoxic cytotoxins 
      Lavaggi, María Laura; Nieves, Marcos; Cabrera, Mauricio; Olea Azar, Claudio; López de Ceráin, Adela; Monge, Antonio; Cerecetto, Hugo; González, Mercedes (2010)
      We have identified phenazine 5,10-dioxides as prodrugs for antitumour therapy that undergo hypoxic-selective bioreduction to form cytotoxic species. Here, we investigated some structural modifications in order to find new ...
    • Study of 5-nitroindazoles' anti-Trypanosoma cruzi mode of action: Electrochemical behaviour and ESR ... 
      Rodríguez, Jorge; Gerpe, Alejandra; Aguirre, Gabriela; Kemmerling Weis, Ulrike; Piro, Oscar; Arán, Vicente; Maya Arango, Juan; Olea Azar, Claudio; González, Mercedes; Cerecetto, Hugo (2009)
      New indazole derivatives have been developed to know about structural requirements for adequate anti-Trypanosoma cruzi activity. In relation to position 1 of indazole ring, we have observed that a butylaminopentyl substituent ...
    • Study of benzo[a]phenazine 7,12-dioxide as selective hypoxic cytotoxin-scaffold. Identification of ... 
      Lavaggi, María Laura; Cabrera, Mauricio; Aravena, María de los Ángeles; Olea Azar, Claudio; López de Ceráin, Adela; Monge, Antonio; Pachón, Gisela; Cascante, Marta; Bruno, Ana María; Pietrasanta, Lía I.; González, Mercedes; Cerecetto, Hugo (2010)
      Phenazine 5,10-dioxides are prodrugs for antitumor therapy that undergo hypoxic-selective bioreduction to form cytotoxic species. Here we investigate the expanded system benzo[a]phenazine 7,12-dioxides as selective hypoxic ...
    • Synthesis and evaluation of new heteroaryl nitrones with spin trap properties 
      Barriga González, G.; Aliaga, C.; Chamorro, E.; Olea Azar, Claudio; Norambuena, E.; Porcal, W.; González, M.; Cerecetto, H. (Royal Society of Chemistry, 2020)
      A new series of heteroaryl nitrones were synthesized and evaluated as free radical traps due to the results showed in our previous report. The physicochemical characterization of these new nitrones by electron spin resonance ...