Browsing by Author "32782bb4-2ea8-4b23-a8f6-732db4c81ec3"

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    • Ca2+/calmodulin kinase II increases ryanodine binding and Ca2+-induced sarcoplasmic reticulum Ca2+ release ... 
      Ferrero, Paola; Said, Matilde; Sánchez, Gina; Vittone, Leticia; Valverde, Carlos; Donoso Laurent, Paulina; Mattiazzi, Alicia; Mundiña-Weilenmann, Cecilia (2007)
      We aimed to define the relative contribution of both PKA and Ca2+/calmodulin-dependent protein kinase II (CaMKII) cascades to the phosphorylation of RyR2 and the activity of the channel during β-adrenergic receptor (βAR) ...
    • High fat diet induced obesity produces spontaneous ventricular arrhythmias and increases the activity of ... 
      Sánchez, Gina; Araneda, Felipe; Peña, Juan Pedro; Finkelstein, José Pablo; Riquelme, Jaime A.; Montecinos, Luis; Barrientos Briones, Genaro; Llanos Vidal, Paola; Pedrozo Cibils, Zully; Said, Matilde; Bull Simpfendorfer, Ricardo; Donoso Laurent, Paulina (MDPI, 2018)
      Ventricular arrhythmias are a common cause of sudden cardiac death, and their occurrence is higher in obese subjects. Abnormal gating of ryanodine receptors (RyR2), the calcium release channels of the sarcoplasmic reticulum, ...
    • Reversible redox modifications of ryanodine receptor ameliorate ventricular arrhythmias in the ischemic-reperfused ... 
      Becerra, Romina; Román, Bárbara; Di Carlo, Mariano; Mariangelo, Juan Ignacio; Salas, Margarita; Sánchez, Gina; Donoso Laurent, Paulina; Schinella, Guillermo; Vittone, Leticia; Wehrens, Xander; Mundiña Weilenmann, Cecilia; Said, Matilde (American Physiological Society, 2016)
      Previous results from our laboratory showed that phosphorylation of ryanodine receptor 2 (RyR2) by Ca2+ calmodulin-dependent kinase II (CaMKII) was a critical but not the unique event responsible for the production of ...