Browsing by Author "34f5565f-f60b-466e-9f04-c8910b792101"
Now showing items 1-5 of 5
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Morales, Sebastián; De Mayo, Tomas; Gulppi, Felipe Andrés; González Hormazábal, Patricio; Carrasco, Valentina; Reyes, José Miguel; Gómez, Fernando; Waugh, Enrique; Jara, Lilian (MDPI AG, 2018)© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Breast cancer (BC) is one of the most frequent tumors affecting women worldwide. microRNAs (miRNAs) single-nucleotide polymorphisms (SNPs) likely contribute to BC ...
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Fernández Moya, Alejandro; Morales, Sebastián; Arancibia, Trinidad; González Hormazábal, Patricio; Tapia, Julio; Godoy Herrera, Raúl; Reyes, José Miguel; Gómez, Fernando; Waugh, Enrique; Jara Sosa, Lilian (MDPI, 2020)The genetic variations responsible for tumorigenesis are called driver mutations. In breast cancer (BC), two studies have demonstrated that germline mutations in driver genes linked to sporadic tumors may also influence ...
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Jara, Lilian; Acevedo, Monica L.; Blanco, Rafael; Castro, Victor G.; Bravo, Teresa; Gómez, Fernando; Waugh, Enrique; Peralta, Octavio; Cabrera, Elsa; Reyes, José M.; Ampuero Llanos, Sandra; González Hormazábal, Patricio (2007)Several studies have reported that mutations in genes involved in maintenance of genome integrity may be responsible for increased cancer risk. Human RAD51, known to function in DNA repair, interacts with a number of ...
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González Hormazábal, Patricio; Reyes, Jose M.; Blanco, Rafael; Bravo, Teresa; Carrera, Ignacio; Peralta, Octavio; Gomez, Fernando; Waugh, Enrique; Margarit, Sonia; Ibañez, Gladys; Santos, José Luis; Jara, Lilian (2012)Since the discovery of the BRCA1 and BRCA2 genes, much work has been carried out to identify further breast cancer (BC) susceptibility genes. BARD1 (BRCA1-associated ring domain) was originally identified as a BRCA1-interacting ...
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Jara, Lilian; Dubois, Karen; Gaete, Daniel; De Mayo, Tomas; Ratkevicius, Nikalai; Bravo, Teresa; Margarit, Sonia; Blanco, Rafael; Gómez, Fernando; Waugh, Enrique; Peralta, Octavio; Reyes, Jose M.; Ibáñez, Gladys; González Hormazábal, Patricio (Springer New York, 2010)The double-strand break (DSB) DNA repair pathway has been implicated in breast cancer (BC). RAD51 and its paralogs XRCC3 and RAD51D play an important role in the repair of DSB through homologous recombination (HR). Some ...