Browsing by Author "36e352c4-673a-40f0-acc1-6160371167a9"

Now showing items 1-18 of 18

    • Applicability of ENCHANTED trial results to current acute ischemic stroke patients eligible for intravenous ... 
      Robinson, Thompson G.; Bray, Benjamin D.; Paley, Lizz; Sprigg, Nikola; Wang, Xia; Arima, Hisatomi; Bath, Philip M.; Broderick, Joseph P.; Durham, Alice C.; Kim, Jong S.; Lavados Germain, Pablo Manuel; Lee, Tsong Hai; Martins, Sheila; Nguyen, Thang H.; Pandian, Jeyaraj D.; Parsons, (SAGE Publications Inc., 2019)
      Background: Randomized controlled trials provide high-level evidence, but the necessity to include selected patients may limit the generalisability of their results. Methods: Comparisons were made of baseline and outcome ...
    • Blood pressure variability and outcome in acute ischemic and hemorrhagic stroke: a post hoc analysis of the ... 
      Minhas, Jatinder S.; Wang, Xia; Lavados Germain, Pablo Manuel; Moullaali, Tom J.; Arima, Hisatomi; Billot, Laurent; Hackett, Maree L.; Olavarria, Veronica V.; Middleton, Sandy; Pontes-Neto, Octavio; De Silva, H. Asita; Lee, Tsong Hai; Pandian, Jeyaraj D.; Mead, Gillian E.; Watkins (Nature Publishing Group, 2019)
      The Head Positioning in Acute Stroke Trial (HeadPoST) is a pragmatic, international, cluster crossover randomized trial of 11,093 patients with acute stroke assigned to a lying-flat (0°) or sitting-up (head elevated ≥30°) ...
    • Characteristics, management and response to alteplase in China versus non-China participants of the ENCHANTED trial 
      Song, Lily; Wang, Xia; Robinson, Thompson; Lindley, Richard I.; Arima, Hisatomi; Lavados Germain, Pablo Manuel; Chen, Xiaoying; Chalmers, John; Anderson, Craig S.; Anderson, Craig S. (BMJ Publishing Group, 2017)
      © 2017 BMJ Publishing Group. All rights reserved. Background The characteristics of patients with acute ischaemic stroke (AIS) and their management vary across regions, which may influence outcomes. We examined for ...
    • Early Blood Pressure Lowering Does Not Reduce Growth of Intraventricular Hemorrhage following Acute ... 
      Chan, Edward; Anderson, Craig S.; Wang, Xia; Arima, Hisatomi; Saxena, Anubhav; Moullaali, Tom J.; Delcourt, Candice; Wu, Guojun; Wang, Jinchao; Chen, Guofang; Lavados Germain, Pablo Manuel; Stapf, Christian; Robinson, Thompson; Chalmers, John (S. Karger AG, 2016)
      © 2016 The Author(s). Background: Intraventricular hemorrhage (IVH) extension is common following acute intracerebral hemorrhage (ICH) and is associated with poor prognosis. Aim: To determine whether intensive blood pressure ...
    • Early blood pressure lowering in patients with intracerebral haemorrhage and prior use of antithrombotic ... 
      Lili, Song; Sandset, Else Charlotte; Arima, Hisatomi; Heeley, Emma; Delcourt, Candice; Chen, Guofeng; Yang, Jie; Wu, Guojun; Wang, Xia; Lavados Germain, Pablo Manuel; Huang, Yining; Stapf, Christian; Wang, Jiguang; Robinson, Thompson; Chalmers, John; Lindley, Richard I.; Anderson, Craig S. (BMJ Publishing Group, 2016-12)
      Objective Antithrombotic agents increase risks of intracerebral haemorrhage (ICH) and associated adverse outcomes. We determined differential effects of early blood pressure (BP) lowering in patients with/without ...
    • Ethnicity and other determinants of quality of functional outcome in acute ischemic stroke: The ENCHANTED trial. 
      Chen, Xiaoying; Wang, Xia; Delcourt, Candice; Li, Jingwei; Arima, Hisatomi; Hackett, Maree L.; Robinson, L.; Lavados, Pablo M.; Lindley, Richard I.; Chalmers, John; Anderson, Craig S. (Lippincott Williams & Wilkins, 2020)
      Background and Purpose-Patient-centered outcomes are important. We aimed to determine predictors of health-related quality of life (HRQoL) and develop utility-weighted modified Rankin Scale (mRS) scores in thrombolyzed ...
    • Frequency, determinants, and effects of early seizures after thrombolysis for acute ischemic stroke The ... 
      Xu, Ying; Hackett, Maree L.; Chalmers, John; Lindley, Richard I.; Wang, Xia; Li, Qiang; Robinson, Thompson; Arima, Hisatomi; Lavados Germain, Pablo Manuel; Anderson, Craig S. (Lippincott Williams & Wilkins, 2017)
      Background: Seizures after ischemic stroke have not been well-studied. We aim to determine the frequency, determinants, and significance of early seizures after thrombolysis for acute ischemic stroke. Methods: Data are ...
    • Intensive care unit admission for patients in the INTERACT2 ICH blood pressure treatment trial: characteristics, ... 
      Wartenberg, Katja E.; Wang, Xia; Muñoz Venturelli, Paula; Rabinstein, Alejandro A.; Lavados Germain, Pablo Manuel; Anderson, Craig S.; Robinson, Thompson (Springer, 2017-06)
      Background Wide variation exists in criteria for accessing intensive care unit (ICU) facilities for managing patients with critical illnesses such as acute intracerebral hemorrhage (ICH). We aimed to determine the predictors ...
    • Low dose vs standard dose alteplase for patients with acute ischemic stroke secondary analysis of the ... 
      Wang, Xia; Robinson, Thompson G.; Lee, Tsong-Hai; Lavados Germain, Pablo Manuel (American Medical Association, 2017)
      IMPORTANCE: A lower dose of intravenous alteplase appears to be a safer treatment option than the standard dose, reducing the risk of symptomatic intracerebral hemorrhage. There is uncertainty, however, over how this effect ...
    • Low-versus standard-dose alteplase in patients on prior antiplatelet therapy: the Enchanted trial (enhanced ... 
      Robinson, Thompson G.; Wang, Xia; Arima, Hisatomi; Bath, Philip M.; Billot, Laurent; Broderick, Joseph P.; Demchuk, Andrew M.; Donnan, Geoffery A.; Kim, Jong S.; Lavados Germain, Pablo Manuel; Lee, Tsong Hai; Lindley, Richard I.; Martins, Sheila C. O.; Olavarria, Veronica V.; Pandian, Jeyaraj D.; Parsons, Mark W.; Pontes Neto, Octavio M.; Ricci, Stefano; Sato, Shoichiro; Sharma, Vijay K.; Nguyen, Thang H.; Wang, Ji Guang; Woodward, Mark; Chalmers, John; Anderson, Craig S. (Lippincott Williams & Wilkins, 2017)
      Background and Purpose-Many patients receiving thrombolysis for acute ischemic stroke are on prior antiplatelet therapy (APT), which may increase symptomatic intracerebral hemorrhage risk. In a prespecified subgroup analysis, ...
    • Mannitol and outcome in intracerebral hemorrhage: Propensity score and multivariable intensive blood pressure ... 
      Wang, Xia; Arima, Hisatomi; Yang, Jie; Zhang, Shihong; Wu, Guojun; Woodward, Mark; Muñoz Venturelli, Paula; Lavados Germain, Pablo Manuel; Stapf, Christian; Robinson, Thompson; Heeley, Emma; Delcourt, Candice; Lindley, Richard I.; Parsons, Mark; Chalmers, John; Anderson, Craig S. (Lippincott Williams and Wilkins, 2015)
      © 2015 American Heart Association, Inc. Background and Purpose.Mannitol is often used to reduce cerebral edema in acute intracerebral hemorrhage but without strong supporting evidence of benefit. We aimed to determine the ...
    • Positive impact of the participation in the Enchanted trial in reducing door to needle time 
      Yang, Jie; Wang, Xia; Yu, Jian Ping; Hang, Jing; Lavados Germain, Pablo Manuel; Robinson, Thompson; Arima, Hisatomi; Lindley, Richard I.; Anderson, Craig S.; Chalmers, John (Nature Publishing Group, 2017)
      Door-to-needle time (DNT) is a key performance indicator for efficient use of intravenous thrombolysis in acute ischemic stroke (AIS). We aimed to determine whether DNT improved over time in the Enhanced Control of ...
    • Practice patterns for neurosurgical utilization and outcome in acute intracerebral hemorrhage: intensive ... 
      Guo, Rui; Blacker, David J.; Wang, Xia; Arima, Hisatomi; Lavados Germain, Pablo Manuel; Lindley, Richard I.; Chalmers, John; Anderson, Craig S.; Robinson, Thompson (Oxford university press, 2017)
      BACKGROUND: The prognosis in acute spontaneous intracerebral hemorrhage (ICH) is related to hematoma volume, where >30 mL is commonly used to define large ICH as a threshold for neurosurgical decompression but without clear ...
    • Prognostic Significance of Hyperglycemia in Acute Intracerebral Hemorrhage: The INTERACT2 Study 
      Saxena, Anubhav; Anderson, Craig S.; Wang, Xia; Sato, Shoichiro; Arima, Hisatomi; Chan, Edward; Munoz-Venturelli, Paula; Delcourt, Candice; Robinson, Thompson; Stapf, Christian; Lavados Germain, Pablo Manuel; Wang, Jiguang; Neal, Bruce; Chalmers, John; Heeley, Emma (Lippincott Williams and Wilkins, 2016)
      © 2016 American Heart Association, Inc. We aimed to determine associations of baseline blood glucose and diabetes mellitus with clinical outcomes in participants of the Intensive Blood Pressure Reduction in Acute Cerebral ...
    • Prophylactic heparin in acute intracerebral hemorrhage: a propensity score-matched analysis of the INTERACT2 study 
      Muñoz Venturelli, Paula; Wang, Xia; Lavados Germain, Pablo Manuel; Stapf, Christian; Robinson, Thompson; Lindley, Richard; Heeley, Emma; Delcourt, Candice; Chalmers, John; Anderson, Craig S. (SAGE, 2016)
      Background: Indication and timing of pharmacological venous thromboembolism prophylaxis in intracerebral hemorrhage patients is controversial. Aims: To determine whether use of subcutaneous heparin during the first 7 ...
    • Significance of intraventricular hemorrhage in Acute intracerebral hemorrhage intensive Blood Pressure ... 
      Chan, Edward; Anderson, Craig S.; Wang, Xia; Arima, Hisatomi; Saxena, Anubhav; Moullaali, Tom J.; Heeley, Emma; Delcourt, Candice; Wu, Guojun; Wang, Jinchao; Chen, Guofang; Lavados Germain, Pablo Manuel; Stapf, Christian; Robinson, Thompson; Chalmers, John; Huang, Yining (Lippincott Williams and Wilkins, 2015)
      © 2015 American Heart Association, Inc. Background and Purpose: Intraventricular hemorrhage (IVH) with spontaneous intracerebral hemorrhage indicates a poor prognosis but uncertainty exists over the pattern of association. ...
    • Validation of the simplified modified Rankin scale for stroke trials: Experience from the ENCHANTED ... 
      Chen, Xiaoying; Li, Jingwei; Anderson, Craig; Lindley, Richard; Hackett, Maree; Robinson, Thompson; Lavados Germaín, Pablo; Wang, Xia; Arima, Hisatomi; Chalmers, John; Delcourt, Candice (Sage, 2020)
      Background and aims The structured, simplified modified Rankin scale questionnaire (smRSq) may increase reliability over the interrogative approach to scoring the modified Rankin scale (mRS) in acute stroke research and ...
    • Withdrawal of active treatment after intracerebral haemorrhage in the INTERACT2 study 
      Venturelli, Paula Muñoz; Wang, Xia; Zahuranec, Darin B.; Lavados Germain, Pablo Manuel; Stapf, Christian; Lindley, Richard; Delcourt, Candice; Chalmers, John; Anderson, Craig S.; Robinson, Thompson G.; Robinson, Thompson G. (Oxford University Press, 2017)
      © The Author 2016. Published by Oxford University Press on behalf of the British Geriatrics Society. Background: in the second Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2), a minority ...