Browsing by Author "3b2bdaf1-bc9f-42d0-9b50-42ce5bc675bb"
Now showing items 1-20 of 32
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Bono Merino, María Rosa; Reyes, Lilian I.; Rosemblatt Silber, Mario César (1999)We present a simple non-radioactive cytometry-based assay that permits the simultaneous quantitation of cell adhesion of distinct subsets of cells contained in a mixture without any previous fractionation. The procedure ...
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Sauma Mahaluf, Daniela; Crisóstomo, Natalia; Fuentes, Camila; Gleisner, María Alejandra; Hidalgo, Yessia; Fuenzalida, María José; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (Springer, 2017)Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by increased autoantibody production that leads to multiple tissue injuries. Dendritic cells (DCs) are important orchestrators of immune responses ...
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Bono Merino, María Rosa; Simon, Valeska; Rosemblatt Silber, Mario César (1989)It has been established that early events in lymphocyte activation involve a rise in intracellular Ca++ as well as changes in the flux of other ions. Although a Ca++ channel has been postulated to participate in the early ...
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Mora, J.R.; Bono Merino, María Rosa; Rosemblatt Silber, Mario César; Rodriguez, S.; Morales, J.; Buckel, E.; Fierro, A. (2001)
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Lennon Duménil, Ana María; Ottone, Catherine; Rosemblatt Silber, Mario César; Fellous, Marc; Bono Merino, María Rosa; Alcaïde-Loridan, Catherine (Springer-Verlag, 1998)In this study, various sets of somatic cell hybrids, generated by the fusion of epithelial cell lines with B-lymphoblastoid cell lines, were analyzed for the expression of major histocompatibility complex (MHC) class ...
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Pino Lagos, Karina; Michea, Paula; Sauma Mahaluf, Daniela; Alba, Andrea; Morales, Jorge; Bono Merino, María Rosa; Fierro, Alberto; Rosemblatt Silber, Mario César (Society of Biology of Chile, 2010)One of the mechanisms for generation of tolerance involves immature dendritic cells (DCs) and a subpopulation of regulatory CD4+ CD25+ T lymphocytes (TREG). The purpose of this work was to analyze how Cyclosporine A (CsA), ...
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Gleisner, M. A.; Rosemblatt Silber, Mario César; Fierro, J. A.; Bono Merino, María Rosa (2011)Background: Dendritic cells (DCs) are professional antigen-presenting cells able to induce immunity or tolerance. The interactions of immature DCs with naive T lymphocytes induce peripheral tolerance through mechanisms ...
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Moore, C.; Sauma Mahaluf, Daniela; Reyes, P. A.; Morales, J.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Fierro, J. A. (2010)Background: CD4+CD25+Foxp3+ regulatory T cells (Treg) play an essential role in immune tolerance, suppressing responses against self-antigens. Additionally, Treg play an important role in maintaining immunosuppression to ...
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Fierro, Alberto; Mora, J. Rodrigo; Bono Merino, María Rosa; Morales, Jorge; Buckel, Erwin; Sauma Mahaluf, Daniela; Rosemblatt Silber, Mario César (2003)
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Jørgensen, Trine N.; Alfaro, Jennifer; Enriquez, Hilda L.; Jiang, Chao; Loo, William M.; Atencio, Stephanie; Gubbels Bupp, Melanie R.; Mailloux, Christina M.; Metzger, Troy; Flannery, Shannon; Rozzo, Stephen J.; Kotzin, Brian L.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; (2010)Autoantibodies are of central importance in the pathogenesis of Ab-mediated autoimmune disorders. The murine lupus susceptibility locus Nba2 on chromosome 1 and the syntenic human locus are associated with a loss of immune ...
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Sauma Mahaluf, Daniela; Espejo, P.; Ramirez, A.; Fierro, A.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2011)The Notch signalling pathway has recently been linked to T helper 1 (Th1)/T helper 2 (Th2) cell polarization via a mechanism involving differential expression of Notch ligands, Delta-like and Jagged, in antigen-presenting ...
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Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2004)Research regarding the interactions between the endothelium and immune cells has undergone a significant expansion during the past decade. Major shifts of emphasis have been the norm, from the production of a detail catalog ...
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Donas, C.; Carrasco, M.; Fritz, M.; Prado, C.; Tejon, G.; Osorio Barrios, F.; Manríquez, V.; Bono Merino, María Rosa; Pacheco, R.; Loyola, A.; Rosemblatt Silber, Mario César (2016)
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Flores Santibañez, Felipe; Cuadra, Barbara; Fernández, Dominique; Rosemblatt, María V.; Nunez, Sarah; Cruz, Pablo; Gálvez Cancino, Felipe Ignacio; Cárdenas, J.C.; Lladser, Álvaro; Rosemblatt Silber, Mario César; Bono Merino, María Rosa; Sauma Mahaluf, Daniela (Frontiers Media SA, 2018)Memory CD8(+) T cells are ideal candidates for cancer immunotherapy because they can mediate long-term protection against tumors. However, the therapeutic potential of different in vitro-generated CD8(+) T cell effector ...
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Burgos, Patricia; Metz, Claudia; Bull, Paulina; Pincheira, Roxana; Massardo, Loreto; Errázuriz, Carolina; Bono Merino, María Rosa; Jacobelli, Sergio; González, Alfonso (AAAS, 2000)OBJECTIVE: To explore the role of the NF - kappaB/Rel transcription factor family in autoimmunity, we investigated whet her peripheral blood mononuclear cells (PBMC) and T cells from the blood of patients ...
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Barbieri, Giovanna; Deffrennes, Virginie; Prod'homme, Thomas; Vedrenne, Jocelyn; Baton, Fabrice; Cortes, Claudio; Fischer, Alain; Bono Merino, María Rosa; Lisowska-Grospierre, Barbara; Charron, Dominique; Alcaïde-Loridan, Catherine (2002)The class II transactivator (CIITA) controls both the constitutive and IFN-γ inducible expression of HLA-D genes. In addition, through the squelching of another transactivator CREB-binding protein, CIITA was more recently ...
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Sauma Mahaluf, Daniela; Mora, J. R.; Fierro, Alberto; Morales, J.; Herzog, C.; Buckel, E.; Rosemblatt Silber, Mario César; Bono Merino, María Rosa (2002)
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Castro, Andrea; Bono Merino, María Rosa; Simon, Valeska; Rosemblatt Silber, Mario César (Elsevier GmbH, 1996)The development of an efficient immune response depends on the capacity of antigen-specific lymphocytes to migrate into secondary lymphoid organs. The first step in the process of lymphocyte extravasation involves lymphocyte ...
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MHC class II-deficient tumor cell lines with a defective expression of the class II transactivator Naves, Rodrigo; Lennon Duménil, Ana María; Barbieri, Giovanna; Reyes, Lilian; Puga, Gisella; Salas, Laura; Deffrennes, Virginie; Rosemblatt Silber, Mario César; Fellous, Marc; Charron, Dominique; Alcaïde-Loridan, Catherine; Bono Merino, María Rosa (Oxford University Press, 2002)MHC class II expression defects have been evidenced in several human tumor cell lines originating from lung cancers or retinoblastoma. Accordingly, the mouse adenocarcinoma and fibrosarcoma cell lines, RAG and L(tk-), do ...
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Hetz Flores, Claudio; Bono Merino, María Rosa; Barros, Luis Felipe; Lagos Mónaco, Rosalba (2002)The cytotoxic effect of microcin E492, a low-molecular-mass channel-forming bacteriocin (7,887 Da) produced by a strain of Klebsiella pneumoniae, was characterized in HeLa cells. At low (5 microg/ml) and intermediate (10 ...